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1

Fournier’s gangrene – current concepts

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Wroblewska M., Kuzaka B., Borkowski T., Kuzaka P., Kawecki D., Radziszewski P.
Polish Journal of Microbiology
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2014
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tom 63
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nr 3
Fournier’s gangrene (FG) is a rapidly progressive form of infective necrotising fasciitis of the perineal, genital, or perianal regions, leading to thrombosis of the small subcutaneous vessels and necrosis of the overlying skin. It is believed that the occurrence of the disease in women is underreported and may be unrecognised by some clinicians. Fournier’s gangrene is a life-threatening condition, constituting an urological emergency. Many patients with Fournier’s gangrene have medical or surgical conditions, which are predisposing factors to this disease or its more severe or fatal course. These comprise diabetes mellitus, hypertension, alcoholism and advanced age. Recent reports in the literature point to changes in the epidemiology of FG, comprising an increasing age of patients. Several authors reported that the mean age of FG patients is at present 53–55 years. Prognosis in FG patients is based on FGSI (Fournier’s gangrene severity index) score. Despite the progress in medical care for FG patients, the mortality rate reported in the literature remains high – most often 20–40%, but ranges from 4% to 80%. The most common isolates cultured from FG lesions are both Gram-positive and Gram-negative, as well as strictly anaerobic bacteria. Recently community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as an etiological agent of FG with severe clinical course and even fulminant sepsis. Rarely FG may have a fungal etiology, being caused by yeast-like fungi Candida spp. or by moulds. Antibiotics should be administered parenterally and in doses high enough to reach an effective concentration in the infected tissues.
2

Wykorzystanie techniki real-time PCR w diagnostyce opryszczkowego zapalenia mózgu jako powikłania zapalenia opon mózgowo-rdzeniowych wywołanego przez Listeria monocytogenes - opis przypadku

100%
Dzieciatkowski T., Przybylski M., Marchel H., Kawecki D., Prokopienko M., Młynarczyk G.
Postępy Mikrobiologii
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2010
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tom 49
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nr 4
3
Content available remote

Sleep study in patients with overweight and obesity

100%
Namyslowski G., Scierski W., Mrowka-Kata K., Kawecka I., Kawecki D., Czecior E.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 6
59-65
Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by repetitive collapse of the pharyngeal airway during sleep, which leads to oxygen desaturation, sleep fragmentation and daytime somnolence. Obesity is one of the most important risk factor for the development of OSAS. The exact mechanisms responsible for the relationship between obesity and OSAS are still unclear. The fat deposits in the pharynx region as well as the reduction in the lung volume have been considered as factors that might be responsible for the increase of the upper airway collapsibility. The aim of our study was to evaluate the correlation between the Body Mass Index (BMI) and sleep study parameters in overweight and obese patients suffering from breathing disturbances during sleep. We studied a group of 106 consecutive obese or overweight patients with a primary complaint of snoring or other breathing disturbances during sleep. In all cases, BMI and sleep studies (PolyMESAM) were examined. We evaluated relationship between the BMI and sleep study parameters such as Respiratory Disturbance Index (RDI), Apnea Index (AI), Desaturation Index (DI) and Average of Lowest Saturation (LSAT). The results showed the lack of significant statistical correlations between BMI and all the sleep parameters studied in the overweight patients and the statistical positive correlation between the BMI and RDI in the obese cases. We conclude that BMI determination may be considered as a simple, yet important predictor, of the OSAS in the group of obese patients.
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