Wyniki wyszukiwania

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Dawkowanie tramadolu w postaci czopkow u psow z punktu widzenia farmakokinetyki

100%

Lebkowska-Wieruszewska B., Kowalski C., Giorgi M., Saccomanni G.

Magazyn Weterynaryjny

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2009

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tom 18

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nr 10

1118

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Farmakokinetyka tramadolu oraz jego glownych metabolitow po jednorazowym podaniu per os tabletki o przedluzonym uwalnianiu oraz czopkow per rectum u psow

100%

Lebkowska-Wieruszewska B., Kowalski C. J., Saccomanni G., Giorgi M.

Medycyna Weterynaryjna

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2009

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tom 65

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nr 10

687-692

The aim of the present study is to evaluate the pharmacokinetics of T and its major metabolites M1, M2 and M5 after the single oral administration of an SR tablet and rectal suppositories in dogs (4-6 mg·kg⁻¹ m.c.). The plasma concentration data after SR-tablet and rectal administration were fitted on the basis of a mono- and non-compartmental model, respectively. T plasma concentration after SR tablet administration was quantitatively detected in three dogs, M1 was quantized in only one dog while M2 and M5 were quantized in all the dogs. T showed median values of Cmax, Tmax and T₁/₂ of 40 (20-170) ng·mL⁻¹, 3 (4-2) and 1.88 (2.21-1.44) hours, respectively. M5 showed median values of Cmax, Tmax and T₁/₂ of 0.1 (90-190) ng·mL⁻¹, 2 (3-1) and 4.23 (6.58-1.85) hours, respectively. M2 showed median values of Cmax, Tmax and T₁/₂ of 220 (80-330) ng·mL⁻¹, 4 (7-3) and 4.49 (6.39-1.57) hours, respectively. Following rectal administration, T was detected from 5 minutes up to 10 h in a smaller amount than M5 and M2. T median value of Cmax was 140 ± 60 ng·mL⁻¹ in 0.56 ± 0.41 h (Tmax). K₀₁ t₁/₂ and K₁₀ t₁/₂ were 0.27 ± 0.25 h and 2.24 ± 1.82 h, respectively. M1 was detectable from 5 min up to 2 h, showing low values (7-28 ng·mL⁻¹). The present findings suggest oral SR tablet and suppository rectal formulation have similar pharmacokinetic behavior and would not have suitable pharmacokinetic characteristics to be administered once-a-day as an effective and safe treatment for pain in dogs.

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Pharmacokinetics of tramadol and metabolites after injective administrations in dogs

88%

Giorgi M., Del Carlo S., Lebkowska-Wieruszewska B., Kowalski C. J., Saccomanni G.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 4

The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.

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Zastosowanie tramadolu w iniekcji u psów

88%

Lebkowska-Wieruszewska B., Kowalski C. J., Saccomanni G., Del Carlo S., Giorgi M.

Magazyn Weterynaryjny

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2012

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tom 21

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nr 07

Ograniczanie wyników

2 Magazyn Weterynaryjny

1 Medycyna Weterynaryjna

1 Polish Journal of Veterinary Sciences

4 Giorgi M.

4 Lebkowska-Wieruszewska B.

4 Saccomanni G.

3 Kowalski C. J.

2 Del Carlo S.

1 Kowalski C.

1 2012

1 2010

2 2009

Dawkowanie tramadolu w postaci czopkow u psow z punktu widzenia farmakokinetyki

Farmakokinetyka tramadolu oraz jego glownych metabolitow po jednorazowym podaniu per os tabletki o przedluzonym uwalnianiu oraz czopkow per rectum u psow

Pharmacokinetics of tramadol and metabolites after injective administrations in dogs

Zastosowanie tramadolu w iniekcji u psów