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LC determination and stability assessment of macrolide antibiotics azithromycin and spiramycin in bulk and tablet samples

100%

Mahmoudi A.

International Letters of Natural Sciences

2015

tom 47

Development and validation of rapid HPLC method for quantifying macrolide antibiotics azithromycin (AZI) and spiramycin (SPI) in bulk and tablet samples is described. Determination was performed on a reversed phase C18 ODB column (250×4.6 nm I.D) at ambient temperature, and employing a UV-detection set at 210 nm. The mobile phase consists of acetonitrile –2-methyl-2- propanol–hydrogenphosphate buffer, pH 6.2, with 1.8% triethylamine (32:8: up to 100, v/v/v), delivered at a flow-rate of 1.1 mL min-1. The assay is linear in concentration ranges of: 0.004–4.8 and 0.0003–1.2 mg mL−1 for azithromycin and spiramycin, respectively, with detection limit of 0.02% for SPI and 0.03% for AZI. Recovery experiments revealed recovery of 98.51–100.82%. The applicability of this method in stability assessment studies is evaluated.

Taxonomic identity of Microtus qazvinensis Golenishchev et al. 2003 (Rodentia, Arvicolinae) from the northwest of Iran

51%

Mahmoudi A., Darvish J., Aliabadian M.

Acta Theriologica

2015

tom 60

nr 1

The Qazvin vole Microtus qazvinensis, an endemic species of Iran, shows an obvious similarity in both morphological and karyological traits to other members of the “guentheri” species group. Such similarities challenge the species status of this taxon. In this study, the relationships of social voles, and in particular M. qazvinensis, were reevaluated based on phylogeny of the mitochondrial gene for cytochrome b and morphological, karyological, and morphometric data. The Bayesian inference and maximum likelihood trees showed the same topology. The genetic distance between the sister species M. qazvinensis (Iran) and Microtus dogramacii (Turkey) was 2.8 %, which is comparable to other sister taxa pairs within Microtus. We confirmed that M. qazvinensis, while having a close relationship to M. dogramacii on molecular trees, shows differences to other species from the guentheri group. As a result, our data support the taxonomic position of M. qazvinensis as a valid species, found in a separate geographical region, within the guentheri group.

Ograniczanie wyników

1 Acta Theriologica

1 International Letters of Natural Sciences

2 Mahmoudi A.

1 Aliabadian M.

1 Darvish J.

2 2015

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LC determination and stability assessment of macrolide antibiotics azithromycin and spiramycin in bulk and tablet samples

Taxonomic identity of Microtus qazvinensis Golenishchev et al. 2003 (Rodentia, Arvicolinae) from the northwest of Iran