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The purpose of this prospective, double-blinded, and placebo-controlled clinical trial was to investigate the efficacy of topical cream, containing 0.1% retinoic acid for the treatment of tail gland hyperplasia in cats. Nineteen privately owned cats diagnosed with tail gland hyperplasia, based on history and clinical findings were randomly assigned to either a placebo or an active ingredient treatment group. Clinical evaluations were done by the same investigator, who scored clinical healing, at the beginning, during, and at the end of the treatment. Both owners and investigators were blinded to the allocation to the groups. It was demonstrated that retinoic acid gel treatment significantly decreased (P<0.05) the investigator's clinical scores while no significant changes were detected in the placebo treatment group. In conclusion, treatment with 0.1% retinoic acid cream was effective for the topical management of tail gland hyperplasia in the cats included in the study.
In the present study, we aimed to provide information on the serum content of sialic acids (TSA, LBSA, and PBSA), total antioxidant capacity (TAC), and adenosine deaminase (ADA) activity in cattle affected with naturally acquired theileriosis and anaplasmosis. A total of 55 Holstein cattle, comprising of 15 clinically healthy control animals, 20 cattle with theileriosis, and 20 with anaplasmosis, were used. Diagnosis was based on clinical signs, Giemsa stained blood or lymph node aspirate, and PCR assay. For the PCR assay, Tams 1 primers were used. The obtained results suggested that the concentration of sialic acids and ADA activity were significantly higher; and TAC were significantly lower in the theileriosis and anaplasmosis groups in contrast to the control group. In conclusion, the increased level of sialic acids and ADA in theileriosis and anaplasmosis may be attributable to the stimulation of the host immune response. In contrast, the reduced level of TAC may reflect a decrease in the antioxidant capacity.
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