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Up-regulation of cochlear Hes1 expression in response to noise exposure

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Wang B., Liu Y., Zhu X., Chi F., Zhang Y., Yang M.

Acta Neurobiologiae Experimentalis

2011

tom 71

nr 2

Hes l, a hairy and enhancer of split homolog, negatively regulates inner ear hair cell differentiation. The main objective of this study was to investigate the status of the Hes l gene in the noise-damaged cochlea in relation to the degree of noise-induced hearing loss (NIHL). Adult albino guinea pigs were exposed to white-band noise (115 dB sound pressure level). Noise exposure for either 1 or hours induced significant elevations of threshold in auditory brainstem response (ABR) compared with unexposed controls. Succinate dehydrogenase staining showed that white-band noise exposure caused significant outer hair cell losses. In addition, we found significant up-regulations of cochlear Hesl mRNA and protein expressions following acoustic trauma, and Hesl mRNA expression was positively correlated with NIHL. These findings suggest that up-regulation of Hes l expression in response to noise exposure may be one of the underlying mechanisms of NIHL.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Chi F.

1 Liu Y.

1 Wang B.

1 Yang M.

1 Zhang Y.

1 Zhu X.

1 2011

Wyniki wyszukiwania

Up-regulation of cochlear Hes1 expression in response to noise exposure