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Sequence determination and analysis of S-adenosyl-L-homocysteine hydrolase from yellow lupine [Lupinus luteus]

100%

Brzezinski K., Janowski R., Podkowinski J., Jaskolski M.

Acta Biochimica Polonica

2001

tom 48

nr 2

The coding se quences of two S-adenosyl- L-homocysteine hy dro las es (SAHases) were iden ti fied in yel low lu pine by screenig of a cDNA li brary. One of them, cor re spond ing to the complete protein, was sequenced and compared with 52 other SAHase se - quences. Phylogen etic analy sis of these proteins identified three groups of the enzymes. Group A com prises only bac te rial se quences. Group B is sub di vided into two sub groups, one of which (B1) is formed by an i mal se quences. Sub group B2 con sist of two dis tinct clus ters, B2a and B2b. Clus ter B2b com prises all known plant se quences, in clud ing the yel low lu pine en zyme, which are dis tin guished by a 50-residue in sert. Group C is het er o ge neous and contains SAHases from Archaea as well as a new class of an i mal en zymes, dis tinctly dif fer ent from those in group B1.

Structural studies of cysteine proteases and their inhibitors

51%

Grzonka Z., Jankowska E., Kasprzykowski F., Kasprzykowska R., Lankiewicz L., Wiczk W., Wieczerzak E., Ciarkowski J., Drabik P., Janowski R., Kozak M., Jaskolski M., Grubb A.

Acta Biochimica Polonica

2001

tom 48

nr 1

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

Ograniczanie wyników

2 Acta Biochimica Polonica

2 Janowski R.

2 Jaskolski M.

1 Brzezinski K.

1 Ciarkowski J.

1 Drabik P.

1 Grubb A.

1 Grzonka Z.

1 Jankowska E.

1 Kasprzykowska R.

1 Kasprzykowski F.

1 Kozak M.

1 Lankiewicz L.

1 Podkowinski J.

1 Wiczk W.

1 Wieczerzak E.

2 2001

Wyniki wyszukiwania

Sequence determination and analysis of S-adenosyl-L-homocysteine hydrolase from yellow lupine [Lupinus luteus]

Structural studies of cysteine proteases and their inhibitors