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1

Bakterie z rodzaju Campylobacter sp. i Salmonella sp. w świetle raportu Europejskiego Urzędu do spraw Bezpieczeństwa Żywności

100%
Chrzastek K., Wieliczko A.
Polskie Drobiarstwo
|
2011
|
tom 19
|
nr 10
2

Wpływ enrofloksacyny, florfenikolu i ceftiofuru na poziom IgY w woreczku żółtkowym oraz surowicy kurcząt

100%
Chrzastek K., Wieliczko A.
Medycyna Weterynaryjna
|
2015
|
tom 71
|
nr 06
Maternal antibodies (matAb) can protect avian embryos and young birds after hatching against vertically transmitted pathogens. In birds, maternal IgY in egg yolk is transferred across the yolk sac through the FcRY receptor to passively immunize chicks. High-affinity binding occurs at pH 6, and does not occur at pH greater than 8.0. This study aimed to evaluate the influence of enrofloxacine, florfenicol, and ceftiofur on maternal IgY concentration in the yolk sac and serum of newly hatched chicks. In this study 184 one-day-old chicks were administered enrofloxacine, florfenicol, or ceftiofur in recommended doses according to the currently recommended treatment schedule. The yolk sac and blood were collected daily from day 1 to day 5 (yolk sac) or 7 (blood) of the experiment. Then, the samples were subjected to radial immunodiffusion investigation. The experiment showed that the concentration of IgY in serum on day 3 after the administration of ceftiofur and florfenicol was higher than that in the control group or the enrofloxacine group. It was also shown that after enrofloxacine treatment the level of IgY was higher in the yolk sac on day 4 of the experiment and lower in serum on day 5 of the experiment compared with the corresponding levels of IgY in the ceftiofur and florfenicol groups. These results suggest that the administration of enrofloxacine, florfenicol, and ceftiofur might influence the efficiency of matAb transfer from the yolk sac to the bloodstream of chicks.
3

Rozwój limfocytów B i T w centralnych narządach limfatycznych ptaków

100%
Chrzastek K., Wieliczko A.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 02
The avian primary lymphoid organs, the bursa of Fabricius and the thymus, are crucial to the normal development of B and T lymphocytes in birds. Birds use gene conversion to produce different classes of immunoglobulins and this process occurs in the bursa of the Fabricius. The microenvironment of the bursa selectively expands those B-cell precursors that have undergone productive V(D)J recombination. On the other hand, the thymus constitutes the microenvironment for T lymphocyte differentiation and the acquisition of self-tolerance. Production of T cells in the thymus is controlled by a combination of positive and negative selection. The differentiation of T cells proceeds along two pathways characterized by the expression of αβ or γδTCRs. Immunologically mature lymphocytes enter the circulation and colonize the peripheral lymphoid organs.
4

Charakterystyka oligodeoksynukleotydow zawierajacych motywy CpG, ich wplyw na komorki ukladu odpornosciowego oraz mozliwosci wykorzystania w medycynie i weterynarii

100%
Chrzastek K., Wieliczko A.
Medycyna Weterynaryjna
|
2010
|
tom 66
|
nr 04
242-245
DNA Bacterial genomes contain many more unmethylated CpG (cytosine-phosphodiester-guanine) dinucleotides than those of vertebrates. This difference in the genome structure allows the innate immune system of vertebrates to distinguish bacterial DNA from self-DNA. Synthetic oligodeoxynucleotides that contain CpG motifs (CpG ODNs) can mimic bacterial DNA and consequently induce various types and levels of immune responses. Synthetic ODNs CpG stimulates the innate immune system, activates non-specific anti-microbial defense systems, and sensitizes antigen-presenting cells to mount both antibody and cell- -mediated immunity against specific antigens. A better understanding of CpG recognition at the molecular level is fundamental to subsequent immunological response which would allow the optimization and application of CpG motifs as therapeutic agents and adjuvants for numerous diseases. It is to be hoped that CpG ODN treatment of animals could also provide a cost-effective alternative to antibiotics by increasing resistance to disease-causative pathogens.
5

Czynniki stresogenne i ich wpływ na układ odpornościowy ptaków - wybrane zagadnienia

100%
Chrzastek K., Wieliczko A.
Polskie Drobiarstwo
|
2010
|
tom 17
|
nr 06
6

Izotypy przeciwciał występujące u gadów z uwzględnieniem ewolucji genów immunoglobulinowych

100%
Chrzastek K., Piasecki T.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 02
Antibodies (immunoglobulins, Ig) were first discovered in mammals, as IgM, IgD, IgG, IgE and IgA. These molecules are responsible for humoral immunity. The reptiles are the last major group of vertebrates in which the organization of the IgH locus and its encoded Ig H chain isotypes has not been well characterized. The reptile expresses three Ig H chain isotypes (IgM, IgD and IgY). The presence of the delta gene demonstrates an evolutionary continuity of IgD. Interestingly. A new study of the leopard gecko shows the presence of a gene that is the orthologue of IgA and IgX.
7
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The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-gamma and IL-1Beta

100%
Chrzastek K., Wieliczko A.
Polish Journal of Veterinary Sciences
|
2014
|
tom 17
|
nr 4
The synthetic unmethylated oligodeoxynucleotides with CpG motifs (CpG ODN) were shown to activate Toll-like receptor 21 (TLR21) and stimulate the innate and adaptive immune system. In this study we tested the expression of TLR21, interferon (IFN)-γ and interleukin (IL)-1β mRNA in the blood after subcutaneous and intraocular application of the class B CpG ODN in chicken. The relative expression of mRNA of TLR21, IFN-γ and IL-1β were quantified at 3, 6, 12, 24 and 72 h post-stimulation. The study revealed that IFN-γ mRNA expression was significantly upregulated 12 h after subcutaneous stimulation with a high and low dose of ODN CpG, whereas the IL-1β mRNA expression levels were significantly upregulated 3 and 72 h after subcutaneous administration. After intraocular administration, the IL-1β mRNA levels were the highest at 24 h post-application, albeit not specifically. This data indicates that class B CpG ODN has the ability to induce TLR21 response in blood when administered parenterally in chicken. In contrast, intraocular administration of CpG ODN was not able to produce a significant increase in cytokine mRNA expression in blood. The data suggest that additional stimulus, e.g. the antigen, may be needed on the site of mucosal administration to activate systemic immune response.
8

Lekooporność bakterii a możliwości terapeutyczne - na podstawie wybranych przykładów w produkcji drobiarskiej

81%
Chrzastek K., Piasecki T., Wieliczko A.
Życie Weterynaryjne
|
2012
|
tom 87
|
nr 02
9

Wykorzystanie metod biologii molekularnej do charakterystyki szczepów bakteryjnych izolowanych od drobiu, na wybranych przykładach

81%
Chrzastek K., Piasecki T., Kuczkowski M., Wieliczko A.
Magazyn Weterynaryjny
|
2012
|
tom 21
|
nr 05 Choroby Ptaków - Monografia
10

Choroba Gumboro ­ istotny problem w produkcji drobiarskiej

81%
Chrzastek K., Wozniak A., Wieliczko A.
Polskie Drobiarstwo
|
2010
|
tom 18
|
nr 12
11

Przeciwciała matczyne u ptaków

81%
Chrzastek K., Wozniak A., Wieliczko A.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 04
12

Zmienność antygenowa wirusa IB a możliwość zwalczania zakaźnego zapalenia oskrzeli kur

81%
Wieliczko K. A., Chrzastek K., Wieliczko A.
Weterynaria w Terenie
|
2010
|
tom 04
|
nr 1
13

Wybrane choroby beztlenowcowe malych przezuwaczy

81%
Bednarski M., Chrzastek K., Miller J.
Weterynaria w Terenie
|
2009
|
tom 03
|
nr 1
45-47
14

Wpływ enrofloksacyny i florfenikolu podawanych w okresie okołolęgowym na wybrane parametry biochemiczne krwi u kurczat

81%
Chrzastek K., Piasecki T., Wieliczko A.
Medycyna Weterynaryjna
|
2012
|
tom 68
|
nr 12
Enrofloxacin and florfenicol are broad-spectrum, synthetic antibacterials widely used in poultry production. In the present study, the effects of enrofoxacin and florfenicol on biochemical parameters in newly hatched chicks were investigated following repeated oral administration for 5 consecutive days. Enrofoxacin or florfenicol was administered once a day, orally at a dose rate of 10 mg or 30 mg/kg b. wt., respectively. The effect of the antibiotics on selected blood parameters (AST, albumins, total proteins, total bilirubin, bile acids, uric acid) revealed insignificant changes after the discontinuation of the drug regimen. This study shows that repeated administration of enrofloxacin or florfenicol during 5 days does not induce any adverse effects when used in a therapeutic regimen.
15

Tyfus kur - nadal istotny problem w produkcji drobiarskiej

81%
Chrzastek K., Kuczkowski M., Wozniak A., Wieliczko A.
Magazyn Weterynaryjny
|
2011
|
tom 20
|
nr 05 Choroby Ptaków - Monografia
16
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Impact of CpG oligodeoxynucleotide stimulation on percentage of T and B cells in chicken

81%
Chrzastek K., Piasecki T., Wieliczko A.
Polish Journal of Veterinary Sciences
|
2013
|
tom 16
|
nr 3
TLR stimulation in chickens has been shown to play a role in the initiation and regulation of innate and adaptive immune responses. The aim of this study was to use flow cytometry to establish the percentage of T and B subset in blood and lymphoid organs in chicks after CpG oligodeoxynucleotide (ODN) stimulation. It was demonstrated that the percentages of CD3⁺, CD4⁺, TCRγ δ⁺ cells and Bu-1⁺MHC class II⁺ cells in blood 24 h post-injection were significantly higher than in the control groups. It was also shown that the percentages of CD3⁺ and CD4⁺ cells in the spleen at 48 h post-injection were significantly higher than in control groups. The percentage of Bu-1⁺ cells in the bursa of Fabricius after CpG ODN stimulation (98.38 ± 0.84) was significantly higher than that found in the non-CpG ODN control group (94.54 ± 2.51) (p ≤ 0.05). The results indicate that class B CpG ODN increases the percentage of both T (especially CD4⁺ cells) and B cells.
17

Aspergiloza - ciągły problem w okresie odchowu drobiu wodnego

81%
Wozniak A., Kuczkowski M., Chrzastek K., Wieliczko A.
Magazyn Weterynaryjny
|
2011
|
tom 20
|
nr 05 Choroby Ptaków - Monografia
18

Zywe 'martwe drewno'

70%
Chrzastek K.
Aura
|
2007
|
nr 07
33-34
19

Prevalence of mutation in gyrA gene at Thr-86 position in Campylobacter jejuni and Campylobacter coli isolated from poultry and humans

61%
Wozniak A., Kuczkowski M., Chrzastek K., Mazurkiewicz M., Wardak S., Szych J., Wieliczko A.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 3
The aim of the following research was to analyse the presence of mutation in gyrA gene in C. jejuni and C. coli strains isolated from broilers, laving hens, turkeys collected between 1994-1996 and 2005-2008, and isolated from humans in 2006. The results of the research demonstrated that the highest percentage (100%) of the isolates showing mutation in gyrA gene was observed in Campylobacter coli strains isolated from turkeys between 2005 and 2008.
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