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1

Copper and zinc concentration in skin neoplastic tissues in dogs

100%
Brodzki A.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 2
Zinc and copper concentrations were assessed in skin tumours and serum of 26 dogs of different breeds. The analysed tumours were situated on legs, chest, and abdomen, 8, 7, and 5 cases, respectively. In 2 cases, the tumours were situated on the tail, anal region, and head. On the basis of a histopathological examination, 17 tumours were classified as malignant, while 9 were classified as benign ones. The dogs age-matched to those with neoplastic changes belonged to the control group. However, they were subjected to surgery due to reasons other than tumours. Samples of skin with subcutaneous tissue and serum obtained from these animals were handled in an identical procedure to those of the other groups. The spectrophotometric atomic absorption method and PAY-UNICAM apparatus were used to determine zinc and copper concentrations. It was demonstrated that the concentration of zinc and copper in malignant tumours was significantly increased in relation to the tissues obtained from healthy animals. Furthermore, tissue concentration of copper in benign tumours was significantly increased in comparison to the controls. In conclusion, the determination of zinc and copper concentrations in malignant neoplastic tissues and serum of dogs may be used as an additional diagnostic indicator conforming histopathological examination of tumour malignancy.
2

Zlamanie zuchwy u konia w okolicy siekaczy

63%
Polkowska I., Brodzki A.
Magazyn Weterynaryjny
|
2008
|
tom 17
|
nr 06
686-687
3

Drogi dostepu chirurgicznego do stawu biodrowego psa

63%
Silmanowicz P., Brodzki A.
Magazyn Weterynaryjny
|
2001
|
tom 10
|
nr 10
24-31
4

Automatyczny blok foliowy - nowe rozwiazania

63%
Brodzki A.
Owoce, Warzywa, Kwiaty
|
1997
|
nr 17-18
5
5

Diagnostic and prognostic value of cellular proliferation assessment with Ki-67 protein in dogs suffering from benign and malignant perianal tumors

51%
Brodzki A., Lopuszynski W., Brodzki P., Tatara M. R.
Folia Biologica
|
2014
|
tom 62
|
nr 3
6
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The concentration of free amino acids in blood serum of dairy cows with primary ketosis

51%
Marczuk J., Brodzki P., Brodzki A., Kurek L.
Polish Journal of Veterinary Sciences
|
2018
|
tom 21
|
nr 1
7

Effects of cytostatics on the selected parameters of cell-mediated immunity in dogs

51%
Brodzki P., Wrona Z., Piech T., Brodzki A.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 1
The aim of the study was to assess the effects of tamoxifen and cyclophosphamide on the selected cell-mediated immunity parameters in dogs. The study included 18 dogs aged 5-10 years. The experimental group consisted of 12 animals with neoplastic lesions classified as the first or second staging group (according to the WHO TMN classification). This group was divided into two subgroups: I - six dogs receiving oral tamoxifen, and II - six dogs with cyclophosphamide administered orally. The control group included six healthy dogs. The blood was sampled from the saphenous access vein two times at 14-d intervals before the drug administration, three times every 7 d during administration, and two times every 14 d after completion of the therapy. The basic blood tests were carried out and the subpopulations of TCD4+ and TCD8+ lymphocytes, and phagocytic activity of granulocytes and monocytes were determined using flow cytometry. It was found that tamoxifen induced a marked increase in WBC and neutrophil counts, increased phagocytic activity of monocytes, and changed the CD4+:CD8+ ratio (in favour of cytotoxic lymphocyte subpopulation). These findings indicated the stimulation of cell-mediated immunity mechanisms. Cyclophosphamide caused a substantial decrease in the overall leukocyte pool and reduced the percentage of cells activated for phagocytosis, both neutrophils and monocytes even after completion of its administration, which proves its immunosuppressive effects.
8

Ciało obce w pęcherzu moczowym psa - radiologiczny obraz przypadku

51%
Lojszczyk-Szczepaniak A., Brodzki A., Zylinska B.
Magazyn Weterynaryjny
|
2012
|
tom 21
|
nr 03
9

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

51%
Brodzki A., Brodzki P., Tatara M. R., Kostro K.
Bulletin of the Veterinary Institute in Puławy
|
2015
|
tom 59
|
nr 3
The aim of the study was to determine total antioxidative capacity (TAC) and zinc concentration in serum of dogs suffering from perianal tumours just before the start of the antihormonal treatment (AHT) and one and six months later. The study was performed on 45 dogs divided into two groups: control group suffering from non-malignant tumours (N = 24) and a group with malignant neoplastic changes (N = 21). Serum TAC and zinc concentrations were measured using photometric and atomic absorption spectrophotometric methods. Six months after the start of the AHT, TAC was significantly lower by 10.6% in dogs with malignant tumours when compared to controls (P = 0.03). In the non-malignant group, serum zinc concentration was higher before the treatment than in the malignant group, while the opposite results were observed six months later (P < 0.001). In the non-malignant group, gradually decreasing values of serum zinc concentration at each stage of the investigation were observed, while the opposite results were obtained in the malignant group (P < 0.05). The obtained results indicate that malignant neoplastic process is associated with significantly reduced TAC. Determination of serum zinc concentration in dogs with non- malignant and malignant perianal tumours may have practical diagnostic and prognostic values and may serve towards increasing the effectiveness of AHT monitoring.
10

Ropień torebki jajnikowej u suki po zabiegu sterylizacji

51%
Brodzki P., Brodzki A., Dabrowski R.
Medycyna Weterynaryjna
|
2011
|
tom 67
|
nr 10
Reproductive system disorders in bitches are commonplace for small animal veterinary surgeons. Surgical intervention is very often considered as an effective treatment in such cases. Ovariohysterectomy in bitches is the most common surgical procedure on the reproductive system for inducing surgical contraception. Numerous advantages as well as disadvantages may result from ovariohysterectomy, especially when one considers the possibility of an inappropriate course of the surgical procedure and resultant complications. This case report describes the presence of an ovarian capsule abscess in a bitch as a post-surgery complication due to failed surgical removal of the ovary. Moderate weakness, apathy, reduced feed consumption, periodical vomiting and modest polidypsia were observed as clinical symptoms in the bitch. Surgical removal of the pathologically changed ovary and its capsule was performed as an effective treatment that was followed by relevant pharmacotherapy. It is worth mentioning here that spaying a bitch without total removal of the ovaries may have positive consequences such as hormonal prevention of urinary inconsistency or obesity. On the other hand, among the negative consequences, vaginal prolapse, neoplastic transformation, ovarian tumor growth and ovarian capsule abscess are listed. All these possible conditions need to be clearly explained to the owner before the planned surgery.
11

Serum concentration of free amino acids in dogs suffering from perianal tumours

51%
Brodzki A., Brodzki P., Szpetnar M., Tatara M. R.
Bulletin of the Veterinary Institute in Puławy
|
2013
|
tom 57
|
nr 1
The aim of the study was to determine serum free amino acid concentration in male dogs suffering from benign and malignant perianal tumours. Serum concentrations of cysteic acid, glutamic acid, glutaminę, aspartic acid, glycine, γ-aminobutyric acid, tryptophan, methionine, arginine, taurine, threonine, tyrosine, alanine, valine, isoleucine, and leucine were significantly changed in dogs suffering from benign and/or malignant tumours when compared to the control group (P<0.05). Serum concentration of serine, phenylalanine, lysine and histidine was not influenced in dogs with neoplastic disease (P>0.05). The evaluation of serum free amino acid concentration, has shown that threonine, glutamic acid, alanine, valine, isoleucine, leucine, γ-aminobutyric acid, and glycine have the highest diagnostic and prognostic value in dogs suffering from benign and malignant perianal tumours. Highly diagnostic and prognostic value in relation to benign tumour growth was also found while evaluating branched chain and acidic groups of amino acids. Serine, phenylalanine, lysine, and histidine, as well as alkaline amino acids were proved not to have diagnostic and prognostic value in dogs with the tumours. Thus, the evaluation of free amino acid concentration may serve diagnostic purposes and help in tumour malignancy differentiation. The elaborated experimental model max be used in further studies on neoplastic disease development and monitoring of applied treatment efficiency.
12

Nowotwory zlosliwe lozyska pazura u psow

51%
Lopuszynski W., Komsta R., Brodzki A., Orzelski M.
Magazyn Weterynaryjny
|
2005
|
tom 14
|
nr 03
4-6
13

Błoniak ziarnisty jajnika u suki - przypadek kliniczny

51%
Brodzki P., Piech T., Brodzki A.
Magazyn Weterynaryjny
|
2012
|
tom 21
|
nr 09
14

Przypadek ciężkiego porodu u kotki spowodowany wodogłowiem płodów

51%
Brodzki P., Brodzki A., Piech T.
Medycyna Weterynaryjna
|
2012
|
tom 68
|
nr 02
Distocia (difficult parturition) in small animals is a common problem in veterinary practice. In such cases immediate, professional help is required. Causes of distocia can be classified as maternal (absolute narrowing of the birth canal, uterine inertia or too strong uterine contractions, pelvic obstructions like tumors, abscesses or hematomas) or fetal (absolute fetal oversize, simultaneous impaction of fetuses from uterine horns into the body of the uterus, monstrosities, etc.). An owner or inexperienced veterinarian can contribute or even be the reason of difficult parturition. The authors describe the case of distocia in a cat caused by hydrocephalus in the kitten. This kind of monstrosity occurs extremely rarely in queens (female cats). The fetus is unable to move down the birth canal due to an oversized head and delivery is ceased. There is only one possible therapeutic procedure in this case: cesarean section. The majority of veterinarians think that a cesarean section in small animals should be performed in the case of any prolonged delivery regardless of the reason. The priority is to rescue fetuses as well as keeping the female in good condition (which deteriorates in the course of prolonged labor). Unfortunately, the majority the causes of distocia cannot be prevented. A basic knowledge concerning the normal birth process and a careful monitoring of animal behavior by the owner will help to detect problems early and get prompt veterinary assistance. This will give the owner and the female the best chance of delivering live healthy kittens.
15

Vascular endothelial growth factor in prognosis of splenic malignant tumours in dogs

51%
Sobczynska-Rak A., Polkowska I., Brodzki A.
Bulletin of the Veterinary Institute in Puławy
|
2014
|
tom 58
|
nr 2
The aim of the study was to determine the levels of the vascular endothelial growth factor (VEGF) in the serum of dogs suffering from splenic malignant tumours, prior to splenectomy, as well as three and six months after the surgery. Tumours and blood samples were collected from 10 dogs of various breeds, aged between 7 and 13 years, and from 10 control animals. Tumour sections were fixed in 10% buffered formalin for 24 h. T he type of tumour was determined according to the WHO classification. Blood samples were centrifuged and the obtained sera were subjected to immunoenzymatic assays to determine the VEGF levels. The median of VEGF levels in the serum of dogs suffering from splenic malignant tumours was 37.85 pg/mL (15.40-107.18 pg/mL). The highest values were observed in dogs with confirmed metastases (107.18 pg/mL and 65.43 pg/mL). The VEGF values in control group were between 0.1 pg/mL and 13.04 pg/mL. A comparative analysis of the VEGF levels against the animals' survival time indicated that VEGF overexpression may serve as a prognostic factor in cases of malignant tumours of the spleen.
16

Magnesium in tumours of the dogs' skin

51%
Brodzki A., Szponder T., Pasternak K., Sztanke M.
Bulletin of the Veterinary Institute in Puławy
|
2004
|
tom 48
|
nr 3
17

Influence of tamoxifen on sexual impulse and semen biological values in male dogs

51%
Brodzki P., Wrona Z., Krakowski L., Brodzki A.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 3
The study was conducted on 12 male dogs (5 to 10 years of age). The animals were divided into 2 groups: the experimental one (6 tamoxifen-treated dogs) and the control one (6 clinically healthy dogs). Besides, a clinical examination evaluating the overall state of health and sexual impulse, the examination of testosterone level in the blood serum was performed as well as the examination of semen (spermatozoa concentration, percentage of dead spermatozoa, evaluation of spermatozoa morphology, and evaluation of spermatozoa cell membrane activity - HOS test). It was found that tamoxifen had a negative influence on the function of the reproductive system in the dogs and caused, already in the first week of the treatment, the worsening of most of the evaluated characteristics of the semen and later, after the second week of the treatment, it produced aspermia with the complete loss of male fertility. The loss of fertility turned out to be periodical and lasted for about 60 d. After that time, the dogs regained the ability to produce ejaculate, though of much weakened quality, but later it was gradually improving.
18

Występowanie, etiologia i antyhormonalne leczenie guzów okolicy odbytu u psów samców

45%
Brodzki A., Sobczynska-Rak A., Brodzki P., Tatara M. R., Silmanowicz P.
Medycyna Weterynaryjna
|
2014
|
tom 70
|
nr 10
The aim of the study: Perianal gland tumors in dogs are the third most prevalent tumors among all neoplastic diseases in males, and are considered a serious health impairment. It has been shown that perianal gland tumors are hormone-dependent, and the most frequently diagnosed type of these tumors are adenomas. The aim of the study was to evaluate the occurrence of perianal tumors in dogs in the Lublin region. Moreover, dogs with perianal gland tumors were subjected to antihormonal treatment. Materials and methods: This study involved the use of both Tamoxifen, as an antiestrogen, and Androcur, as an antiandrogen. Tamoxifen and Androcur were administered on the basis of sex hormone levels in the serum of the dogs. The study was performed on 45 male dogs aged 8-17 years, which suffered from perianal tumors. The diagnostic procedure was based on the histopathological examination of biopsies and on serum 17β-estradiol and testosterone concentrations determined by the ELISA method. In all experimental groups, 27 cases were diagnosed as adenoma (non-malignant tumors), 14 dogs suffered from epithelioma (low malignancy), and 4 patients had carcinoma (malignant tumors). Basic antihormonal treatment lasted for one month. Dogs with an elevated 17β-estradiol level underwent antiandrogen treatment, whereas an increased concentration of testosterone was the diagnostic criterion for antiandrogen treatment. Results: The antihormonal therapy of dogs with adenoma was effective in 90% of cases, and there was no recurrence of the disease during the 6-month period of observation. In 10% of adenoma cases, the size of perianal tumors was reduced significantly, and there was no bleeding. In such cases, the antihormonal treatment was prolonged for another two weeks. Eventually, all adenoma tumors disappeared completely, and the disease did not recur. In the case of epithelioma, the treatment was effective in 70% of patients, whereas in the remaining 30% of animals the size of tumors was significantly reduced. However, in the latter group, the extension of therapy by 2 weeks did not eliminate neoplastic changes. During the 6-month period of clinical observation, 60% of epithelioma cases showed recurrence. The antihormonal treatment of dogs with carcinoma resulted only in a reduced size of perianal tumors. In all such cases, the recurrence of neoplastic disease was observed with the following rapid growth of the tumors. Conclusions: This study has shown that antihormonal treatment was the most effective in dogs suffering from adenoma, less effective in patients with epithelioma, and the least effective in those with carcinoma.
19

Zastosowanie kleju fibrynowego w operacjach u malych zwierzat

45%
Szponder T., Brodzki A., Orzelski M., Polkowska I., Bielawski A.
Magazyn Weterynaryjny
|
2006
|
tom 15
|
nr 01
30
20

Endometrial cytology at luteal and follicular phases of the ovarian cycle in cows

45%
Brodzki P., Brodzki A., Kurek L., Marczuk J., Tatara M. R.
Annals of Animal Science
|
2015
|
tom 15
|
nr 1
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