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Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor

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Politowska E., Kazmierkiewicz R., Wiegand V., Fahrenholz F., Ciarkowski J.

Acta Biochimica Polonica

2001

tom 48

nr 1

Cholesterol, an integral component of membranes in Eucaryota, is a modifier of membrane properties. In vivo studies have demonstrated that cholesterol can also modulate activities of some G protein-coupled receptors (GPCRs), which are integral membrane proteins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholesterol with the receptor, as recently demonstrated for the cholecystokinin type β (CCKRβ ) or the oxytocin receptor (OTR). Using molecular modelling, we studied conformational preferences of cholesterol and several of its analogues. Subsequently, we simulated the distributions of their preferred conformations around the surface of OTR, CCKR β and a chimeric oxytocin/cholecystokinin receptor. Consequently, we suggest residues on the surface of OTR which are potentially significant in the OTR/cholesterol interaction.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Ciarkowski J.

1 Fahrenholz F.

1 Kazmierkiewicz R.

1 Politowska E.

1 Wiegand V.

1 2001

Wyniki wyszukiwania

Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor