The impact of neuraminidase on apoptosis in cultures of blood lymphocytes isolated from rats bearing Morris hepatoma

• Autorzy: Gasiorowski K , Steciwko A. , Grata-Borkowska U. , Drobnik J.
• Języki publikacji: EN

Abstrakty

EN

Lymphocytes were obtained by heart-punction from rats bearing Morris hepatoma. In the short term, 18-hour cultures of these lymphocytes exhibited a significantly higher amount of apoptotic cells than lymphocyte cultures from the healthy, control animals. Neuraminidase, injected into the caudal vein of the rats with Morris hepatoma, caused a marked lowering in the amount of apoptotic blood-lymphocytes and an elevation of the amount of viable cells. The possible mechanism of neuraminidase preventing the apoptosis of blood-circulating lymphocytes in tumour hosts is discussed herein.

Słowa kluczowe

EN

neuraminidase; lymphocyte; Morris hepatoma; apoptosis; rat

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2004
• Tom: 09
• Numer: 2
• Opis fizyczny: p.389-399,fig.,ref.

Twórcy

autor

Gasiorowski K

• Wroclaw Medical University, Kochanowskiego 14, 51-601 Wroclaw, Poland

autor

Steciwko A.

autor

Grata-Borkowska U.

autor

Drobnik J.

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