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2006 | 55 | 1 |

Tytuł artykułu

Interferon alpha in the establishment of latency by herpes simplex virus type 1 strain tr.

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The effect of interferon (IFN) alpha on the establishment and maintenance of neuronal latency and viral reactivation is still not known. Using cell culture methods and sensitive RT-PCR methods, we show that the presence of antiserum to IFN alpha promotes the establishment of HSV-1 tr latent infection. We suggest that IFN alpha is an important tool not only for the control of productive but also latent HSV-1 infection.

Wydawca

-

Rocznik

Tom

55

Numer

1

Opis fizyczny

p.49-52,fig.,ref.

Twórcy

autor
  • National Institute of Hygiene, Warsaw, Poland
autor

Bibliografia

  • Chatterjee S., A.D. Lakeman, R.J. Whitley and E. Hunter. 1984. Effect of cloned human interferons on the replication of and cell fusion induced by herpes simplex virus. Virus Research 1: 81-87.
  • Devi-Rao G.B., D.C. Bloom, J.G. Stevens and E.K. Wagner. 1994. Herpes simplex virus type 1 DNA replication and gene expresión during explant-induced reactivation of latently infectedd murine sensory ganglia. J. Virol. 68: 1271-1282.
  • Domke-Opitz I., P. Straub and H. Kirchner. 1986. Effect of interferon on replication of herpes simplex virus types 1 and 2 in human macrophages. J. Virol. 60: 37-42.
  • Fraser N.W., T.M. Block and J.G. Spivack. 1992. The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology 191: 1-8.
  • Halford W.P., B.M. Gebhardt and D.J.J. Carr. 1996. Peristent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1. J. Immunol. 157: 3542-3549.
  • Harle P., E. Lauret, P.M. Pitha, E. De Maeyer and D.J. Carr. 2001. Expression of human and macaque type I IFN transgenes interferes with HSV-1 replication at the transcriptional and translational levels: IFN-beta is more potent than IFN alpha2. Virology 290: 237-248.
  • Halford W.P. and P.A. Schaffer. 2000. Optimized viral dose and transient immunosuppression enable herpes simplex virus ICPO-null mutants to establish wild type levels of latency in vivo. J. Virol. 74: 5957-5967.
  • Hendricks R.L., P.C. Weber, J.L. Taylor, A. Koumbis, T.M. Turnpey and J.C. Glorioso. 1991. Endogenously produced interferon alpha prootects mice from herpes simplex virus type 1 corneal disease. J. General Virol. 72: 1601-1610.
  • Kramer M.F. and D.M. Coen. 1995. Quantification of transcripts from the ICP4 and thymidine kinase genes in mose ganglia latently infected with herpes simplex virus. J. Virol. 69: 1389-1399.
  • Kramer M.F., S.H. Chen, D.M. Knipe and D.M. Coen. 1998. Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J. Virol. 72: 1177-1185.
  • Litwińska B., W. Sadowski and M. Kańtoch. 1991. Temperature-sensitive clones of herpes simplex virus type 1 from laboratory and clinical strains. I. Cloning and basic pathogenetic and immunogenic properties (in Polish). Med. Dośw. Mikrobiol. 43: 55-62.
  • Lausch R.N., Y.H. Su, M. Ritchie and J.E. Oakes. 1991. Evidence endogenous interferon production contributed to the lack of ocular virulence of an HSV intertypic recombinant. Current Eye Research 10: 39-45.
  • Noisakran S., I.L. Campbell and D.J. Carr. 1999. Ectopic expression of DNA encoding IFN-alphal in the cornea protects mice from herpes simplex virus type-1-induced encephalitis. J. Immunol. 162: 4184-4190.
  • Oberman F. and A. Panet. 1988. Inhibition of transcription of herpes simplex virus immediate early genes in interferon treated human cells. J. General Virol. 69: 1167-1177.
  • Pinto A.J., P.S. Morahan, M. Brinton, D. Stewart and E. Gavin. 1990. Comparative therapeutic efficacy of recombinant interferon-alpha, -beta, and-gamma against alphatogavirus, bunyavirus, flavivirus and herpesvirus infections. J. Interferon Research 10: 293-298.
  • Ramakrishnan R., M. Levine and D.J. Fink. 1994. PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J. Virol. 68: 7083-7091.
  • Sawtell N.M. 1997. Comprehensive quantification of herpes simplex virus latency at the single cell level. J. Virol. 71: 5423-5431.
  • Sawtell N.M. 1998. The probability of in vivo reactivation of herpes simplex virus type 1 increases with number of latently infected neurons in ganglia. J. Virol. 72: 6888-6892.
  • Stevens J.G., E.K. Wagner, G.B. Devi-Rao, M.L. Cook and L.T. Feldman. 1987. RNA complementary to a herpes virus gene mRNA is prominent in latently infected neurons. Science 235: 1056-1059.
  • Su Y-H, R.L. Meegalla, R. Chowhan, C. Cubitt, J.E. Oakes, R.N. Lausch, N.W. Fraser and T. Block. 1999. Human corneal cells and other fibroblasts can stimulate the appearance of herpes simplex virus from quiescently infected PC12 cells. J. Virol. 73: 4171-4180.
  • Su Y.-H., J.E. Oakes and R.N. Lausch. 1990. Ocular avirulence of a herpes simplex virus type 1 strain is associated with heightened sensitivity to alpha/beta interferon. J. Virol. 64: 2187-2192.
  • Tal-Singer R., T.M. Lasner, W. Podrzucki, A. Skokotas, J.J. Leary, S.L. Berger and N.W. Fraser. 1997. Gene expresión during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J. Virol. 71: 5268-5276.
  • Wagner E.K. and D.C. Bloom. 1997. Experimental investigation of herpes simplex virus latency. Clin. Microbiol. Rev. 10: 419-443.

Typ dokumentu

Bibliografia

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