EN
The effect of interferon (IFN) alpha on the establishment and maintenance of neuronal latency and viral reactivation is still not known. Using cell culture methods and sensitive RT-PCR methods, we show that the presence of antiserum to IFN alpha promotes the establishment of HSV-1 tr latent infection. We suggest that IFN alpha is an important tool not only for the control of productive but also latent HSV-1 infection.