Zakazenie Helicobacter pylori a stezenie homocysteiny, kwasu foliowego i witaminy B12 w surowicy krwi

• Autorzy: Jarosz M. , Dzieniszewski J. , Ryzko-Skiba M. , Respondek W.

Warianty tytułu

EN

Helicobacter pylori infection and serum concentration of homocysteine, folate and vitamin B12

• Języki publikacji: PL

Abstrakty

PL

50 wybranych losowo chorych przyjmowanych do szpitala, u których wykonano oznaczenia stężeń homocysteiny, witaminy B12 i kwasu foliowego we krwi, podzielono na dwie grupy w zależności od wyniku testu serologicznego na obecność zakażenia H. pylori. W grupie I (kontrolnej) bez zakażenia H. pylori znalazło się 14 chorych (28%), zaś w grupie II (z zakażeniem H. pylori) - 36 chorych (72%). W grupie chorych z zakażeniem H. pylori stwierdzono znamiennie niższe statystycznie średnie stężenie witaminy B12 (279,2 ± 69 pq/ml vs 430 ± 98 pq/ml) (p < 0,001) i kwasu foliowego (4,1 ± 1,2 ng/ml vs 6,8 ± 2,7 ng/ml) (p < 0,05) oraz wyższe stężenie homocysteiny (16,8 ± 3,9 µmol/l vs 12,1 ± 2,8. µmol/l) (p < 0,05). Otrzymane wyniki mogą wskazywać na to, że zakażenie H. pylori może sprzyjać rozwojowi choroby niedokrwiennej serca poprzez wzrost stężenia homocysteiny we krwi, zaś niedokrwistości megaloblastycznej poprzez obniżenie poziomu witaminy B12 i kwasu foliowego.

EN

Fifty sick persons admitted to hospital, for whom determination of homocysteine, vitamin B12 and folate concentration in blood serum was carried out, were divided into two groups depending on the result of the serological test for the presence of H. pylori infection. Group I (control group) without H. pylori infection (28%) consisted of 14 sick persons, whereas group II (with H. pylori infection) consisted of 36 sick persons (72%). Within the group of sick persons with H. pylori infection statistically significantly lower average concentration (p < 0.05) of vitamin B12 (279.2 ± 69 pq/ml vs 430 ± 98 pq/ ml) and folate (488 ± 22 ng/ml vs 6.34 ± 2.7 ng/ml) and higher concentration of homocysteine (16.2 ± 3.9 µmol/1 vs 12.1 ± 2.8 µmol/1) was observed. The results obtained may indicate that H. pylori infection may be conducive to the development of ischaemic heart disease due to increased homocysteine concentration in blood and to megaloblastic anaemia due to a lower level of vitamin B12 and folate.

Słowa kluczowe

PL

infekcja bakteryjna; Helicobacter pylori; surowica krwi; homocysteina; kwas foliowy; witamina B12

• Wydawca: -
• Czasopismo: Żywienie Człowieka i Metabolizm
• Rocznik: 2004
• Tom: 31
• Numer: 1
• Opis fizyczny: s.56-62,tab.,bibliogr.

Twórcy

autor

Jarosz M.

• Instytut Zywnosci i Zywienia w Warszawie, Warszawa

autor

Dzieniszewski J.

autor

Ryzko-Skiba M.

autor

Respondek W.

Bibliografia

• 1. Aguejouf O., Mayo K., Monteiro L., et al.: Increase of arterial thrombosis parameters in chronic Helicobacter pylori infection in mice. Thromb. Res., 2002, 108, 245-248.
• 2. Annibale B., Capurso G., Lahner E., et al.: Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia. Gut 2003, 52, 496-501.
• 3. Auer J., Berent R., Weber T., Eber B.: Helicobacter pylori infection, infectious burden, and coronary artery disease. Am. J. Cardiol., 2002, 90, 87.
• 4. Bettoni L., Rizzini F.L., Tosoni C., Cattaneo R.: Chronic urticaria induced by eradication therapy of Helicobacter pyloria case report. Helicobacter 2002, 7, 269.
• 5. Bulajic M., Maisonneuve P., Schneider Brachert W., et al.: Helicobacter pylori and the risk of benign and malignant biliary tract disease. Cancer 2002, 95, 1946-1953.
• 6. Carloni E., Cremonini F., Di Caro S., et al.: Helicobacter pylori - related extradigestive diseases and effcts of eradication therapy. Dig. Liver Dis., 2000, 32, S214-216.
• 7. Choe Y.H., Kim S.K., Hong Y.C.: The relationship between Helicobacter pylori infection and iron deficieny: seroprevalence study in 937 pubescent children. Arch. Dis. Child., 2003, 88, 178.
• 8. Coppola N., de Stefano G., Marrocco C., et al.: Absence of Helicobacter spp. in the liver of patients with primary or metastatic liver cancer. Hepatology 2002, 36, 1300-1301.
• 9. Dzieniszewski J., Jarosz M.: Postępowanie w zakażeniu Helicobacter pylori (rok 2004). Gastroenterol. Pol., 2004, 11, 1, 41-48.
• 10. Espinola Klein C., Rupprecht H.J., Blankenberg S., et al.: Impact of infectious burden on progression of carotid atheroslerosis. Stroke 2002, 33, 2581-2586.
• 11. Fan X-G, Peng Xi-N, Huang Y., et al.: Helicobacter species ribosomal DNA recovered from the liver tissue of Chinese patients with primary hepatocellular carcinoma. Clin. Infect. Dis., 2002, 35, 1555-1557.
• 12. Figura N., Palazzuoli A., FAglia S., et al.: Infection by CagA-positive Helicobacter pylori strains in patients with ischemic heart disease - Prevalence and association with exercise-induced electrocardiographic abnormalities. Dig. Dis. Sei., 2002, 47, 831-836.
• 13. Franceschi F., Sepulved A.R., Gasbarrini A., et al.: Cross-reactivity of Anti-CagA antibodies with vascular wall antigens - Possible pathogenic link between helicobacter pylori infection and atherosclerosis. Circulation 2002, 106, 430-434.
• 14. Gabrielli M., Pola P., Gasbarrini A.: Helicobacter pylori, CagA-positive strains, and ischemic stroke. Stroke 2002, 33, 1453.
• 15. Gasbarrini A., Carloni E., Gasbarrini G., Ménardt A.: Helicobacter pylori and extra gastric diseases - other Helicobacters. Helicobacter 2003, 8, suppl. 1, 68-76.
• 16. Gasbarrini A., Franceschi F., Armuzzi A., et al.: Extradigestive manifestations of Helicobacter pylori gastric infection. Gut 1999, 45, 19-112.
• 17. Haider A.W., Wilson P.W.F., Larson M.G., et al.: The association of seropositivity to helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study. J. Am. Coll. Cardiol., 2002, 40, 1408-1413.
• 18. Hashino S., Mori A., Suzuki S., et al.: Platelet recovery in patients with idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Int. J. Hematol., 2003, 77, 188-191.
• 19. Hino M., Yamane T., Park K., et al.: Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura. Ann. Hematol., 2003, 82, 30-32.
• 20. Horne B.D., Muhlestein J.B., Strobel G.G., et al.: Greater pathogen burden but not elevated Creactive protein increases the risk of clinical restenosis after percutaneous coronary intervention. Am. Heart J., 2002, 144, 491-500.
• 21. Kaptan K., Beyan C., Ural A.U., et al.: Helicobacter pylori - ist it a novel causative agent in vitamin B12 deficiency? Arch. Intern. Med., 2000, 160, 1349-1353.
• 22. Kohda K., Kuga T., Kogawa K., et al.: Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura. Br. J. Haematol., 2002, 118, 584-588.
• 23. Konturek PC., Bielański W., Konturek S.J., et al.: Progastrin and cyclooxygenase-2 in colorectal cancer. Dig. Dis. Sei., 2002, 47, 1984-1991.
• 24. Kostaki M., Fessatou S., Karpathios T.: Refractory iron-deficiency anaemia due to silent Helicobacter pylori gastritis in children. Eur. J. Pediatr., 2003, 162, 177-179.
• 25. Kowalski M., Rees W., Konturek PC., et al.: Detection of Helicobacter pylori specific DNA in human atheromatous coronary arteries and its association to prior myocardial infarction and ustable angina. Dig. Liver Dis., 2002, 34, 398-402.
• 26. Leung W.K., Ma P.K., Choi PC., et al.: Correlation between Helicobacter pylori infection, gastric inflamation and serum homocysteine concentration. Helicobacter, 2001, 6, 146-150.
• 27. Limburg PJ., Stolzenberg Solomon R.Z., et al.: Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers. Cancer Epidemiol. Biomarkers Prev., 2002, 11, 1095-1099.
• 28. Majka J., Rog T., Konturek PC., et al.: Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors. Med. Sei. Monit., 2002, 8, CR675-684.
• 29. Matsukura N., Ykomuro S., Yamada S., et al.: Association between Helicobacter bilis in bile and biliary tract malignancies: H-bilis in bile from Japanese and Thai patients with benign and malignant diseases in the biliary tract. Jpn. J. Cancer Res., 2002, 93, 842-847.
• 30. Michel M., Khellaf M., Desforges L., et al.: Autoimmune thrombocytopenic purpura and Helicobacter pylori infection. Arch. Int. Med., 2002, 162, 1033-1036.
• 31. Pietroiusti A., Diomedi M., Silvestrini M., et al.: Cytotoxin-associated gene-Apositive helicobacter pylori strains are associated with atherosclerotic stroke. Circulation 2002, 106, 580-584.
• 32. Prasad A., Zhu J.H., Halcox J.PJ, et al.: Predisposition to atherosclerosis by infections role of endothelial dysfunction. Circulation 2002, 106, 184-190.
• 33. Seo J.K., Ko J.S., Choi K.D.: Serum ferritin and Helicobacter pylori infection in children: a seroepidemiologic. study in Korea. J. Gastroenterol. Hepatol., 2002, 17, 754-757.
• 34. Singh R.K., McMahon A.D., Patel H., et al.: Prospective analysis of the association of infection with CagA bearing strains of Helicobacter pylori and coronary heart disease. Heart 2002, 88, 43-46
• 35. Smieja M., Gnarpe J., Lonn E., et al.: Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) study. Circulation 2003, 107, 251-257.
• 36. Stone A.F.M., Mendall M.A., Kaski J.C., et al.: Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes - South Thames trial of antibiotics in myocardial infarction and unstable angina (STAMINA). Circulation 2002, 106, 1219-1223.
• 37. Sugiyama T., Tsuchida M., Yokota K, et al.: Improvement of longstanding iron-deficiency anemia in adults after eradication of Helicobacter pylori infection. Int. Med., 2002, 41, 491-494.
• 38. Szlachcic A.: The link between Helicobacter pylori infection and rosacea. J. Eur. Acad. Dermatol. Venerol., 2002, 16, 328-333.
• 39. Takashima T., Adachi K., Kawamura A., et al.: Cardiovascular risk factors in subjects with Helicobacter pylori infection. Helicobacter 2002, 7, 86-90.
• 40. Tamura A., Fujioka T., Nasu M.: Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid, and homocysteine levels in patients who underwent diagnostic coronary arteriography. Am. J. Gastroenterol., 2002, 97, 861-866.
• 41. Veneri D., Franchini M., Gottardi M.M.D.A., et al.: Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura. Haematologica 2002, 87, 1177-1179.