EN
Clotting disturbances are well documented in veterinary medicine and associated with bleeding caused by damage of coagulate cascade. Homeostasis is defined as the equilibrium between coagulation and fibrinolysis. It is a complicated physiological process protecting the organism against blood loss. As a result of new immunological technology with high specific and sensitive markers it is possible to detect products of fibrynolysis activation, such as D-dimers. Veterinary literature has published very little about the efficacy of various D-dimer test in dogs and horses in diagnosing and evaluating the increase in fibrynogen degradation products. It has been proven that completing standard parameters (pulse, respiration, PCV and anion gap) estimated in horses with colic by using the D-dimer test as well as assessing the activity of phospolipase A₂, the animal’s life expectancy prognosis is radically improved. Because homeostatic cascade activation occurs due to many clinical causes e.g.: injury, chirurgical operation, neoplasm, heart diseases, pregnancy and in the postpartum period, it seems theoretically reasonable to apply the D-dimer test in order to access early diagnosis of life-dangerous abnormalities such as circulative thrombi in blood vessels.