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2015 | 47 |
Tytuł artykułu

LC determination and stability assessment of macrolide antibiotics azithromycin and spiramycin in bulk and tablet samples

Autorzy
Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Development and validation of rapid HPLC method for quantifying macrolide antibiotics azithromycin (AZI) and spiramycin (SPI) in bulk and tablet samples is described. Determination was performed on a reversed phase C18 ODB column (250×4.6 nm I.D) at ambient temperature, and employing a UV-detection set at 210 nm. The mobile phase consists of acetonitrile –2-methyl-2- propanol–hydrogenphosphate buffer, pH 6.2, with 1.8% triethylamine (32:8: up to 100, v/v/v), delivered at a flow-rate of 1.1 mL min-1. The assay is linear in concentration ranges of: 0.004–4.8 and 0.0003–1.2 mg mL−1 for azithromycin and spiramycin, respectively, with detection limit of 0.02% for SPI and 0.03% for AZI. Recovery experiments revealed recovery of 98.51–100.82%. The applicability of this method in stability assessment studies is evaluated.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
47
Opis fizyczny
p.1-10,fig.,ref.
Twórcy
autor
  • Laboratory of Research on Bioactive Products and Biomass Valorization (LRPBVB), Ecole Normale Supérieure–Kouba, P.O. Box 92, Kouba, 16050, Algiers, Algeria
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.agro-4b35ead5-a07d-47ea-b863-46e326326934
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