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1989 | 40 | 4 |
Tytuł artykułu

The influence of propranolol on the hypotensive action of ketanserin in normotensive rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Malinowska, В., Pietraszek, M., Chabielska, E. and Buczko W.: The influence of propranolol on the hypotensive action of ketanserin in normotensive rats. Acta physiol, pol., 1989 40 (4): 356-362. In normotensive rats the effect of different doses of propranolol (1.0, 5.0 and 10.0 mg/kg i.p.) and ketanserin (10.0 mg/kg p.o.) on mean blood pressure and heart rate and on cardiovascular response to noradrenaline (0.1, 0.3, 0.5, 0,7 and 1.0 µg/kg i.v.) was examined. The drugs were given separately or together. Propranolol slightly reduced the hypotensive effect of ketanserin. On the other hand a decrease in heart rate caused by propranolol was not affected by ketanserin. Our results show that propranolol given with ketanserin did not change the effect of the latter on the cardiovascular system.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
40
Numer
4
Opis fizyczny
p.356-362,fig.,ref.
Twórcy
  • Department of Pharmacodynamics, School of Medicine, Bialystok, Poland
  • Department of Pharmacodynamics, School of Medicine, Bialystok, Poland
  • Department of Pharmacodynamics, School of Medicine, Bialystok, Poland
autor
  • Department of Pharmacodynamics, School of Medicine, Bialystok, Poland
Bibliografia
  • 1. Amery, A., Fagard, R., Fiocchi, R., Lijnen, P. Stassen, J., Vanhees, L. (1985) Ketanserin: a new hypotensive drug. J. Cardiovasc. Pharmacol. 7 (suppl. 7). S176-S182.
  • 2. Buczko, W., Pietraszek, M., Chabielska, E., Malinowska, В. (1987) The influence of some hyipotensive drugs on the serotoninergic mechanisms in rat platelets. Tliromb. Haemost. 58. 641-641.
  • 3. Farmer, J. B., Levy, G. P. (1968) A comparison of some cardiovascular properties of propranolol, MJ 1999 and quinidine in relation to their effects in hypertensive animals. Brit. J. Pharmac. 34. 116-126.
  • 4. Fozard, J. R. (1982) Mechanism of hypotensive effect of ketanserin. J. Cardiovasc. Pharmacol. 4. 829-838.
  • 5. Garvey, H. L., Ram, N. (1975) Comparative antihypertensive effects and tissuq distribution of beta adrenergic blocking drugs. J. Pharmacol. Exp. Ther. 194. 220-233.
  • 6. Gordin, A., Saraste, K., Turanlahti, M., Sundberg, S. (1986) Comparison of ketanserin and pindolol in hypertension. J. Hypertension 4 (suppl. 1). S61-S62.
  • 7. Hedner, T., Persson, В. (1985) Ketanserin in combination with ß-adrenergic receptor blocking agents in the treatment of essential hypertension. Brit. J. Clin. Pharmacol. 7 (suppl. 7). S161- S163.
  • 8. Hedner, T., Persson, B. (1984) Ketanserin in combination with ß-adrenergic receptor blocking agents in the treatment of essential hypertension. Brit. J. Clin. Pharmacol. 18. 765-771.
  • 9. Hoyer, D., Engel, G.f Kalkman, H. D. (1985a) Characterization of the 5-HT₁b recognition site in rat brain: binding studies with (-) [¹²⁵ J] Jodocyanopindolol. Eur. J. Pharmacol. 118. 1-12.
  • 10. Hoyer, D., Engel, G., Kalkman, H. O. (1985b) Molecular pharmacology of 5HT₁ and 5HT₂ recognition sites in rat and pig brain membranes: radioligand binding studies with [³ H] 5HT, [³ H] 8-OH-DPAT, (-) [¹²⁵ J] Jodocyanopindolol, [³H] Ketanserin. Eur. J. Pharmacol. 118. 13-23.
  • 11. Kalkman, H. O., Timmermans, P. B., van Zwieten, P. A. (1982) Characterization of the antihypertensive properties of ketanserin (R41468) in rats. J. Pharmac. Exp.Ther. 222. 227-231.
  • 12. Kirch. W., Ohnhaus, E. E. (1986) Double-blind comparison of ketanserin with afenolol: antihypertensive activity and effect on platelet function. J. Hypertension 4 (suppl. 1). S67-S71.
  • 13. Levy, J. V, (1976) Beta-adrenergic receptor blocking drugs in spontaneous hypertension. Amer. J. Med. 61. 779-789.
  • 14. Lewis, P., (1976) The essential action of propranolol in hypertension. Amer. J. Med. 60. 837-852.
  • 15. Leysen, J. E. (1985) Serotoninergic binding sites: In: Serotonin and the Cardiovascular System, (ed. P. M. Vanhoutte) New York, Raven Press, 43-62.
  • 16. Leysen, J. E., Awouters, F., Kennis, L., Laduron, P. M., Vandenberk, J., Janssen, P. A. J. (1981) Receptor binding profile of R 41468, a novel antagonist at 5-HT₂ receptors. Lite Sci. 28. 1015-1022.
  • 17. Mauersberger, H. (1986) Long-term safety and efficacy of ketanserin in essential hypertension: ketanserin versus or in combination with metoprolol. J. Hypertension 4 (suppl. 1). S73-S75.
  • 18. Middlemiss, D. N. (1984) Stereoselective blockade at [³H] -5HT binding sites and at the 5-HT autoreceptor by propranolol. Eur. J. Pharmacol. 101. 289-292.
  • 19. Persson, B., Hedner, T., Henning, M. (1982) Cardiovascular effects in the rat of ketanserin, a novel, 5-hydroxytryptamine receptor blocking agent. J. Pharm. Pharmacol. 34. 442-445.
  • 20. Regoli, D. (1969) Pressor action of beta blocking agents in rats. Can. J. Physiol. Pharmacol. 48. 481-489.
  • 21. Rudnick, G., Bencuya. R., Nelson, P. J., Zito, R. A. (1981) Inhibition of platelet serotonin (transport by propranolol. Mol. Pharmacol. 20. 118-123.
  • 22. Simon, W., Schaz, K., Mann, J. F. E., Ganten, U., Johnson, A. K., Unger, T., Rascher, W., Gaunten, D. (1981) The effects of beta-adrenoceptor blockers on blood pressure responses to central angiotensin II. Neuropharmacology 20. 719-726.
  • 23. Sprouse, J. S., Aghajanian, G. K. (1986) (-)-propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT₁ a selective agonists. Eur. J. Pharmacol. 128. 295-298.
  • 24. Staessen, J., Fagard, R., Fiocchi, R., Lijnen, P., Rorive, G., Amery, A. (1985) Double-blind comparison of ketanserin with propranolol in hypertensive patients, interim report. J. Cardiovasc. Pharmacol. 7 (suppl. 7). S140-S147.
  • 25. Strucker-Boudier, H. A. J., van Essen, H., Nievelstein, H. M. N. W., Smits, J. F. M. (1986) Role of baroreflex activation in the regional hemodynamic effects of the beta-blockers tertatold and propranolol in conscious spontaneously hypertensive rats. Amer. J. Nephrol. 6 (suppl. 2) 25-29.
  • 26. Van Neuten, J. M., Janssen, P. A. J., Van Beek, J., Xhonneux, R., Verbeuren, T. J. Vanhoutte, P. M. (1981) Vascular effects of Ketanserin (R 41468), a novel antagonist of 5HT₂ serotonergic receptors. J. Pharmacol. Exp. Ther. 218. 217-230.
  • 27. Yamamoto, J., Sekiya, A. (1969) On the pressor action of propranolol in the rat. Arch. Int. Pharmacodyn. Ther. 179. 372-380.
  • 28. Waal-Manning, H. J., Brown, S. A., Spears, G. F., Simpson, F. O. (1985) Clinical studies with ketanserin in hypertension. J. Cardiovasc. Pharmacol. 7 (suppl. 7). S154- S158.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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