The influence of propranolol on the hypotensive action of ketanserin in normotensive rats

• Autorzy: Malinowska B. , Pietraszek M. , Chabielska E. , Buczko W.
• Języki publikacji: EN

Abstrakty

EN

Malinowska, В., Pietraszek, M., Chabielska, E. and Buczko W.: The influence of propranolol on the hypotensive action of ketanserin in normotensive rats. Acta physiol, pol., 1989 40 (4): 356-362. In normotensive rats the effect of different doses of propranolol (1.0, 5.0 and 10.0 mg/kg i.p.) and ketanserin (10.0 mg/kg p.o.) on mean blood pressure and heart rate and on cardiovascular response to noradrenaline (0.1, 0.3, 0.5, 0,7 and 1.0 µg/kg i.v.) was examined. The drugs were given separately or together. Propranolol slightly reduced the hypotensive effect of ketanserin. On the other hand a decrease in heart rate caused by propranolol was not affected by ketanserin. Our results show that propranolol given with ketanserin did not change the effect of the latter on the cardiovascular system.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 4
• Opis fizyczny: p.356-362,fig.,ref.

Twórcy

autor

Malinowska B.

• Department of Pharmacodynamics, School of Medicine, Bialystok, Poland

autor

Pietraszek M.

• Department of Pharmacodynamics, School of Medicine, Bialystok, Poland

autor

Chabielska E.

• Department of Pharmacodynamics, School of Medicine, Bialystok, Poland

autor

Buczko W.

• Department of Pharmacodynamics, School of Medicine, Bialystok, Poland

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