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Propofol is an intravenous anaesthetic in which the active substance is 2.6-diizopropylphenol. It may be used for intravenous infusions in single or fractionated doses. Propofol was applied to 25 sheep of both sexes. Anaesthesia was induced with a saturation dose of 6.75 mg/kg bw/min. Afterwards, the substance was applied in sustaining doses. The total dose of Propofol was 0.44 mg/kg bw/min. The animals were under anaesthesia for 45 min. Haematological and biochemical parameters in sheep (10 examined animals) varied within the normal range. Myorelaxation and analgesia proved to be good. When Propofol administration ceased, the animals woke up quite quickly and attained the same state as before anaesthesia. In the course of anaesthesia Propofol should be administered continuously.
The objective of the work was to establish in dogs the effects of propofol anaesthesia without premedication in a single dose and in continuous infusion on blood gas exchange and on haematological parameters. Propofol injected in a single dose of 6.5 mg/kg bw evokes a general anaesthesia lasting for about 5 min. Propofol used continuously at a dose of about 0.5 mg/kg bw/min. enables to obtain a general anaesthesia easy to control in depth and time. In the anaesthesia after a continuous infusion of propofol a transient respiratory acidosis and a decrease of blood oxygenation appears. Moreover, a short-lived statistically significant increase of pulmonary shunt develops.
Clinical practice with small animals often requires the immediate introduction of the patient to short-acting anaesthesia. The aim of the study was the evaluation of the use of midazolam and xylazine as short-acting anaesthesia for dogs. The investigation was carried out on 27 dogs. The general anaesthesia was performed by using a mixture including: atropine 0.05 mg/kg, xylazine 1 mg/kg and midazolam 0.3 mg/kg. The drugs were administered intravenously by using one syringe at a dose dependant on the effects of the operation. Anaesthesia was evaluated testing palpebral reflex, corneal reflex, superficial sensibility and pedal reflex. Body temperature, heart rate, respiratory rate, parameters of acid-base balance and blood oxyganation were determined during anaesthesia. Intravenous administration of atropine, xylazine and midazolam at a dose dependant on the effects of the operation induce general anaesthesia lasting about 20 minutes. The anaesthesia was connected with the loss of consciousness and pain sensitivity. This kind of anaesthesia causes transient acid-base balance disturbances and respiratory depression. The method of anaesthesia used in our study provides fast induction and recovery without antagonists. The negative effect on the anaesthetised animals was minimal.
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