Wyniki wyszukiwania - AGRO

1

The emerging distinct role of TNF-receptor 2 [p80] signalling in chronic inflammatory disorders

100%

Holtmann M. H., Schuchmann M., Zeller G., Galle P. R., Neurath M. F.

Archivum Immunologiae et Therapiae Experimentalis

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2002

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tom 50

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nr 4

2

The immunoradiometric assay for tumor necrosis factor-alpha is an alternative indicator for its bioactivity

100%

Van den Bemb G. C. M.

Applied Biology Communications. Lublin Scientific Center

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1992

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tom 02

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nr 5

3

Ultrastructure of lung granulocytes in the development of the primary focus of Morris hepatoma 5123 subjected to the action of rhTNF-alpha and its mutein VI

88%

Nowak H. F., Terlikowski S., Sulkowski S., Sulkowska M.

Folia Histochemica et Cytobiologica

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1999

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tom 37

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nr 2

4

Influence of culture medium pH on cytotoxicity of CD95L in vitro

88%

Grzela T., Lazarczyk M., Oldak M., Korczak-Kowalska G.

Folia Histochemica et Cytobiologica

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2001

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tom 39

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nr 1

5

TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells

75%

Szoltysek K., Pietranek K., Kalinowska-Herok M., Pietrowska M., Kimmel M., Widlak P.

Acta Biochimica Polonica

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2008

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tom 55

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nr 4

741-748

The signaling pathways that depend on p53 or NFκB transcription factors are essential components of cellular responses to stress. In general, p53 is involved in either activation of cell cycle arrest or induction of apoptosis, while NFκB exerts mostly anti-apoptotic functions; both regulatory pathways apparently interfere with each other. Here we aimed to analyze the effects of NFκB activation on DNA damage-induced apoptosis, either p53-dependent or p53-independent, in a set of human cell lines. Four cell lines, HCT116 and RKO colon carcinoma, NCI-H1299 lung carcinoma and HL60 myeloblastoma, each of them in two congenic variants either containing or lacking transcriptionally competent p53, were used. Cells were incubated with TNFα cytokine to activate NFκB and then treated with ultraviolet or ionizing radiation to induce apoptosis, which was assessed by measurement of the sub-G1 cell fraction. We observed that treatment with TNFα resulted in a significant reduction in the frequency of apoptotic cells in UV-irradiated p53-proficient lines (with exception of the UV-resistant NCI-H1299 cells). This anti-apoptotic effect was lost when cells were pretreated with parthenolide, an inhibitor of NFκB activation. In marked contrast, TNFα-pretreatment of p53-deficient lines resulted in an increased frequency of apoptotic cells after UV irradiation (with exception of HL60 cells). Such anti- and pro-apoptotic influence of TNFα was less obvious in cells treated with ionizing radiation. The data clearly indicates functional interference of both signaling pathways upon the damage-induced apoptotic response, yet the observed effects are both cell type- and stimulus-specific.

6

The protective impact of Trans-Cinnamaldehyde (TCA) against the IL-1beta induced inflammation in in vitro osteoarthritis model by regulating PI3K/AKT pathways

75%

Wu J.-R., Zhong W.-J., Chen Z.-D., Zhu B.-Q., Jiang Y.-Y., Wierzbicki P. M.

Folia Histochemica et Cytobiologica

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2020

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tom 58

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nr 4

7

Lung protection in cardio-pulmonary bypass

75%

Salameh A., Greimann W., Vollroth M., Dhein S., Bahramsoltani M., Dahnert I.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 1

8

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Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants

75%

Strzelecka M., Bzowska M., Koziel J., Szuba B., Dubiel O., Rivera Nunez D., Heinrich M., Bereta J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

139-156

It is believed that bioactive compounds from plant foods may have health beneficial effects and reduce the risk of chronic inflammatory diseases. In this study extracts of 121 plants typical for the traditional Mediterranean diet have been screened for their potential anti-inflammatory activities. The ability of the extracts to inhibit cytokinestimulated, iNOS-dependent synthesis of nitric oxide in murine endothelial cells, without affecting cell viability, was the primary indicator of their anti-inflammatory properties. Based on these experiments we selected eight plant extracts for further analysis: Chrysanthemum coronarium L., Scandix pecten-veneris L., Urospermum picroides (L.) Scop. Ex F. W. Smith, Amaranthus cf. graecizans L., Onopordum macracanthum Schousboe, Eryngium campestre L., Artemisia alba Turra and Merendera pyrenaica (Pourret) Fourn. Only the effects of Onopordum macracanthum could be non-specific since the extract strongly inhibited total protein synthesis. All remaining 7 extracts decreased nitric oxide and TNFa synthesis in the cells of monocyte origin activated with LPS, and 4 of them significantly reduced surface expression of VCAM1 on TNFa-stimulated endothelial cells. All seven plant extracts decreased cytokine or LPS-stimulated iNOS mRNA levels in both cell types. Further research to identify bioactive compounds influencing intracellular signaling pathways activated by cytokines and LPS will consequently be needed in order to better understand these in vitro effects.

9

Reduced [14C]-methionine uptake and fecundity in Schistosoma mansoni females treated with recombinant tumor necrosis factor alpha in vitro

75%

Haseeb M. A., Agrawal R., Fried B.

Acta Parasitologica

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2017

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tom 62

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nr 1

10

Plasma histamine and tumour necrosis factor-alpha levels in Crohn's disease and ulcerative colitis at various stages of disease

75%

Hagel A. F., De Rossi T., Konturek P. C., Albrecht H., Walker S., Hahn E. G., Raithel M.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 4

11

Serum TNF-alpha level in the neoplasm patients qualified for surgical treatment

75%

Gendek-Kubiak H., Grzegorczyk J., Gendek E. G., Kowalski M. L., Berner J.

Archivum Immunologiae et Therapiae Experimentalis. Supplement

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2001

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tom 49

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nr 2

97-102

12

Crystals of recombinant human tumor necrosis factor

75%

Joachimiak A., Giel M., Klysik J. E., Stec W. J., Barciszewski J.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 1

13

Growth factors effects on preimplantation development of mouse embryos exposed to tumor necrosis factor alpha

75%

Glabowski W., Kurzawa R., Wiszniewska B., Baczkowski T., Marchlewicz M., Brelik P.

Reproductive Biology

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2005

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tom 05

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nr 1

14

Characterization of NO and cytokine release by transplantable melanoma cell lines in relationship to their differentiation

75%

Kozlowska K., Zarzeczna M., Cichorek M.

Archivum Immunologiae et Therapiae Experimentalis. Supplement

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2001

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tom 49

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nr 2

103-109

15

The influence of recombinant human tumor necrosis factor [rh-TNFalpha] on granulocyte-macrophage progenitor cells [CFU-GM] and clonogenic leukaemic blasts [CFU-L] in cultures in vitro

75%

Robak T., Korycka A., Gora-Tybor J., Piotrowska-Wrzesien A., Krykowski E.

Archivum Immunologiae et Therapiae Experimentalis

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1992

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tom 40

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nr 5-6

16

26 kD TNFalpha precursor molecule and 17 kD mature TNFalpha form differentiate the clinical status of the patients with ling-standing diabetes mellitus of type I

75%

Zorena K., Mysliwska J., Semetkowska-Jurkiewicz E., Lukaszuk K., Mysliwski A.

Folia Histochemica et Cytobiologica

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1997

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tom 35

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nr 2

17

Synthesis and biological studies on analogs of cyclolinopeptide A with a shortened peptide chain

75%

Siemion I. Z., Pedyczak A., Strug I., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

|

nr 5-6

18

Association of interferon gamma, tumor necrosis factor alpha and interleukin 6 serum levels with systemic lupus erythematosus activity

75%

Robak E., Sysa-Jedrzejewska A., Dziankowska B., Torzecka D., Chojnowski K., Robak T.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

|

nr 6

19

The mechanism of the regulation of PAI-1 gene expression by reactive oxygen species

75%

Swiatkowska M., Pawlowska Z., Szemraj J., Cierniewski C. S.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

20

The effect of danazol on the activity of peritoneal macrophages

75%

Kurzawa R., Barcew-Wiszniewska B., Skowron J.

Folia Histochemica et Cytobiologica

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1997

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tom 35

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nr 2

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