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Nobel Price 2015 for Dr William C. Campbell

100%

Pawlowski Z.

Annals of Parasitology

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2015

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tom 61

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nr 4

2

Targeted drug delivery for anthracyclins using peptidoliposomal constructs

100%

Kaukinen S., Kuosmanen S., Valtanen H., Zhu Y., Simpura I., Haikola M., Tahtinen M., Reinman M., Medina O. P., Kairemo K.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.

3

The use of various animal species for therapeutic purposes in Poland: current perspectives

88%

Kapustka J., Budzynska M.

Acta Scientiarum Polonorum. Zootechnica

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2020

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tom 19

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nr 2

4

Ergonomic modifications of rehabilitation aids - the forearm crutch

88%

Portalska H., Portalski M.

Ergonomia

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2003

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tom Spec.

5

The work of dogs in AAI – the evaluation of welfare and human–dog communication

88%

Rogoza M., Boruta A.

Acta Scientiarum Polonorum. Zootechnica

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2018

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tom 17

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nr 2

6

Importance of basic mechanisms of magnesium in cardiovascular therapy

88%

Kiss Z.

Journal of Elementology

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2005

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tom 10

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nr 4 Suppl.1

40-41

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Expression of genes modulated by epigallocatechin-3-gallate in breast cancer cells

88%

Bogacz A., Wolek M., Juskowiak B., Karasiewicz M., Kaminski A., Uzar I., Polaszewska A., Kostrzewa Z., Czerny B.

Herba Polonica

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2018

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tom 64

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nr 3

Breast cancer is the most common malignant cancer among women. Both drug resistance and metastasis are major problems in the treatment of breast cancer. Therefore, adjuvant therapy may improve patients’ survival and affect their quality of life. It is suggested that epigallocatechin gallate (EGCG) which is well known for its chemopreventive activity and acts on numerous molecular targets may inhibit the growth and metastasis of some cancers. Hence, discovering the metastatic molecular mechanisms for breast cancer may be useful for therapy.The aim of the study was to determine the effect of EGGC on the mRNA expression level of genes such as ZEB1, ABCB1, MDM2, TWIST1 and PTEN in MCF-7 breast cancer cells. MCF7/DOX were cultured in the presence of 0.2 μM DOX and EGCG (20-50 μM). The mRNA expression level was determined by real-time quantitative PCR using RealTime ready Custom Panel 96 kit. Our results showed an important increase (about 2-fold for 20 μM EGCG + 0.2 μM DOX and 2.5-fold for 50 μM EGCG + 0.2 μM DOX, p<0.05) in ZEB1 expression levels. In case of ABCB1 gene lack of influence on the mRNA level was observed (p>0.05). We also observed significant decrease of ZEB1 expression in MCF7 cells with 20 μM and 50 μM EGCG (p<0.05). In addition, EGCG (20 μM) caused an increase of MDM2 and PTEN mRNA levels in almost 100% (p<0.05) and 40% (p>0.05), respectively. Lack of the influence of EGCG was noted for the TWIST1 gene expression. In case of MCF7/DOX we showed an increase of mRNA level of PTEN gene about 50% (p<0.05). These results suggest that EGCG may be potentially used in adjuvant therapy in the breast cancer treatment.

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Deep tissue massage and mobility and pain in the thoracic spine

88%

Srokowska A., Bodek M., Kurczewski M., Srokowski G., Siedlaczek M., Lewandowski A.

Baltic Journal of Health and Physical Activity. The Journal of Gdansk University of Physical Education and Sport

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2019

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tom 11

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nr 2

9

Cancer procoagulant as a marker using for monitoring of oesophageal, stomach and colorectal cancer therapy

88%

Kozuszko B., Skrzydlewska E., Snarska J., Kozlowski M., Zalewski B., Skrzydlewski Z.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

10

Preparation of endotoxin-free bacteriophages

88%

Boratynski J., Syper D., Weber-Dabrowska B., Lusiak-Szelachowska M., Pozniak G., Gorski A.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 2

Bacteriophages (phages) are bacterial viruses that interact with bacterial walls and invade bacterial cells. Moreover, they disturb bacterial metabolism and lead to bacteria lysis. In the case of Gram-negative bacteria crude phage cultures, apart from the phages themselves, the bacterial debris, bacterial proteins and nucleic acids contain endotoxins. These endotoxins (lipopolysaccharides) posses a high degree of toxicity in vitro and in vivo, and their removal is essential for safety in antibacterial bacteriophage therapy. An effective, scaleable purification of bacteriophages from endotoxins was accomplished by sequential ultrafiltration through polysulfone membrane (30 nm) followed by chromatography on sepharose 4B and Matrex Cellulofine Sulfate. The phage fraction after gel filtration chromatography routinely contained endotoxins in the 150-2500 EU/mL range. The procedure yielded bacteriophages contaminated with as little as 0.4-7 EU/ml (Limulus assay). This value lies within the permitted level for intravenous applications (5 EU/kg/h by European Pharmacopoeia, 1997)

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Immunosuppression during Leishmania donovani infection: a potential target for the development of therapy

75%

Flora R., Aghazadeh-Dibavar S., Bandyopadhyay M., Dasgupta S.

Annals of Parasitology

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2014

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tom 60

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nr 4

Dysfunction of T-helper 1 mediated immune responses is a hallmark of the progression of visceral leishmaniosis (VL). Several factors such as altered antigen presentation, and abnormalities in MHC/HLA, antigen processing, and T cell receptor recognition regulate the onset of immunosuppression. Recent investigations on VL patients suggest that susceptibility to visceral leishmaniosis is genetically determined and varies between populations in different geographical locations. Emerging evidence also indicates the importance of the role played by myeloid derived suppressor cells in progressive VL. This study provides a mechanistic view of means to target the signaling mechanisms of immunosuppression to determine potential therapeutic interventions.

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Attitude toward alcoholics and their families

75%

Sulek J., Korczak-Dziurdzik A., Korbel-Pawlas M., Lyznicka M., Czarnecki D.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

349-358

The objective of this work was to find out whether alcoholics undergoing therapy are considered rightful members of society. We also examined the attitudes of society toward the alcoholic’s family. Alcoholism is a specific disorder. Alcohol-addicted persons deny their illness and often engage their closest surrounding in the denial system. They also find in the society a specific margin of consent to drink. Research shows that treated alcoholics believe the society has a low level of knowledge concerning alcohol addiction. They fear the perspective of going back to work or finding a new job after finishing therapy. Studies done among the inhabitants of the mountainous Podhale Region in Poland show that a high percentage of people are convinced that one should be ashamed of being an alcoholic and many would feel awkward in the presence of a sober alcoholic. The people declare that they would not trust a person being treated because of the addiction and name professions that alcoholics should not work in. The spouse of an alcoholic is often blamed for the addiction, and children of alcoholics are perceived as people with worse life perspectives than their peers.

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Ehksperimental'nyje issledovanija ehlektronnykh sistem i metoda terapii endometrita korov millimetrovym ehlektromagnitnym izlucheniem

75%

Dumanskijj A., Mikhailova L.

Motrol. Motoryzacja i Energetyka Rolnictwa

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2015

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tom 17

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nr 5

14

Efficacy of crizotinib therapy for a patient with non-small cell lung cancer with ALK gene rearrangement – case report and review of current therapeutic options

75%

Bargiel J. B., Cabaj J., Chmielewska I., Milanowski J.

Journal of Pre-Clinical and Clinical Research

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2021

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tom 15

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nr 3

15

Cyclooxygenase-2 as a biomarker with diagnostic, therapeutic, prognostic, and predictive relevance in small animal oncology

75%

Szweda M., Rychlik A., Babinska I., Pomianowski A.

Journal of Veterinary Research

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2020

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tom 64

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nr 1

16

Hirudotherapy in veterinary medicine

75%

Sobczak N., Kantyka M.

Annals of Parasitology

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2014

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tom 60

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nr 2

The saliva of medicinal leeches, e.g., Hirudo medicinalis and Hirudo verbana commonly used in hirudotherapy, contains more than 100 bioactive substances with various therapeutic effects, including anticoagulant, vasodilator, thrombolytic, anti-inflammatory and anaesthetic properties. Recently, leeches have been used very successfully in veterinary medicine to treat many diseases of animals, especially dogs, cats and horses. The most common indications for the use of leeches are hip and elbow dysplasia, acute and chronic arthritis, diseases associated with inflammation of tendons, ligaments, and fascia, diseases of the vertebrae and the treatment of scars. Leech therapy is a painless procedure which takes an average of 30 to 120 minutes, the time being dependent on the size of the animal. All leeches used in medical procedures should originate only from certified biofarms. The maintenance of sterile conditions for the culture, transport and storage of medical leeches is very important to protect animals from microbial infections. Hirudotherapy is successfully used in veterinary medicine, especially when traditional treatment is not effective, the effects of treatment are too slow, or after surgery, when the tissues may be threatened by venous congestion.

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MicroRNA-26a-5p: multiple functions, multiple possibilities – a mini-review

75%

Zapolnik P., Zapolnik B.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

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nr 4

18

Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD

75%

Van Overveld F. J., Demkow U., Gorecka D., De Backer W. A., Zielinski J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

273-282

Inhaled corticosteroids have a high level of topical anti-inflammatory activity. However, in patients with COPD these drugs have been reported to exert limited effects. A reduction in histone deacetylase (HDAC) activity is suggested to prevent the anti-inflammatory action of corticosteroids. Cigarette smoke is known to reduce HDAC expression. The aim of this study is to compare the outcome of corticosteroid therapy in both smoking and non-smoking COPD patients. Twenty-three smoking patients and 18 ex-smoking patients with COPD were treated with inhaled corticosteroids for a period of 2 months. Blood and induced sputum samples were collected before and after treatment. Values of FEV1 %-predicted did not change upon the therapy, but there was a trend to improve in the ex-smokers (63.1 64.8%-pred.), compared with a decrease in the smokers (63.3 61.6%-pred.). The levels of the pro-inflammatory cytokine IL-8 increased in the group of smokers from 379 ±78 to 526 ±118 ng/ml. Although not significant, a slight decrease from 382 ±70 to 342 ±62 ng/ml was observed in the group of ex-smokers. The neutrophil related elastase activity showed similar effects after steroid treatment, it went up from 36.4 ±12.0 to 113.5 ±9.7 nmol/l in smokers, and decreased from 346.2 ±72.1 to 131.1 ±6.5 nmol/l in ex-smokers with COPD. These results support the evidence that inhaled corticosteroids have no anti-inflammatory effects in COPD patients, but only when these patients are still smoking. Smoking cessation seems the best therapy for COPD patients.

19

Dendritic cell-based cancer immunotherapies

75%

Fujii S., Takayama T., Asakura M., Aki K., Fujimoto K., Shimizu K.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 3

189-198

20

The controversy over anti-Helicobacter pylori therapy

75%

Bocian K. M., Jagusztyn-Krynicka E. K.

Polish Journal of Microbiology

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2012

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tom 61

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nr 4

Helicobacter pylori is a Gram-negative spiral-shaped bacterium, member of ε-Proteobacteria specifically colonizing the gastric epithelium of humans. It causes one of the most common infections worldwide, affecting about half of the world’s population. However, it should be noted that the prevalence of H. pylori, particularly in the Western world, has significantly decreased coinciding with an increase of some autoimmune and allergic diseases, such as asthma. Various epidemiological studies have also documented a negative association between H. pylori colonization and the presence of GERD (gastroesophageal re/ux disease) and risk of esophageal cancer. Additionally, an upward trend of obesity recently observed in inhabitants of developed countries raised a question about the relationship between H. pylori infection and the human body mass index. The first part of this review describes common, recommended anti-H. pylori treatments. The second part, presents the results of recent experiments aimed at evaluating the association between H. pylori infections and gastro-esophageal diseases, the level of stomach hormones, the human body mass index and allergic diseases. Although some studies suggest an inverse association of H. pylori infection with some health problems of the modern world such as asthma, obesity or GERD, H. pylori should be considered as a harmful human pathogen responsible for serious and sometimes lethal diseases. Thus, many scientists advocate the eradication of H. pylori.

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