Wyniki wyszukiwania - AGRO

1

The role of calcium in signal transduction processes in Sertoli cells

100%

Gorczynska-Fjalling E.

Reproductive Biology

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2004

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tom 04

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nr 3

2

L-cysteine ameliorated testicular toxicity induced by acrylamide in rats

100%

Hossam El-Din M.Omar H. E.-D. M., Abd-elghafar S. K., Fiedan I. O., Ahmed E. A.

European Journal of Biological Research

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2015

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tom 05

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nr 2

3

Does the non-genomic effect of testosterone on social anxiety require the presence of a classical steroid receptor?

100%

Filova B., Domonkos E., Borbelyova V., Babickova J., Tothova L., Ostatnikova D., Celec P., Hodosy J.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 4

Steroid hormones may act through a rapid mechanism that does not require an intracellular steroid receptor and its effects on gene expression. In this study we have analysed this so-called non-genomic effect of testosterone on social anxiety in rats of both sexes using androgen and oestrogen receptor blockers. Male rats were divided into four groups: SHAM-CTRL (a sham operated group treated with oil as vehicle, n=10), SHAM-TST (a sham operated group treated with testosterone at a dose of 1 mg/kg, n=10), GDX-CTRL (a castrated group treated with oil, n=10) and GDX-TST (a castrated group treated with testosterone at a dose of 1 mg/kg, n=10). Female rats were divided into two groups: OVX-CTRL (an ovariectomized group treated with oil, n=10) and OVX-TST (an ovariectomized group treated with testosterone, n=10). The intracellular androgen receptor was blocked with flutamide and both intracellular oestrogen receptors were blocked with tamoxifen (a selective oestrogen receptor modulator). Rats were tested one hour after oil or testosterone administration in the social interaction test. Although the concentration of testosterone was higher in testosterone groups, no significant difference in social interaction was observed between the groups. In summary, in this first study focusing on the non-genomic effects of testosterone on social interaction no rapid effects of testosterone in adult rats were found. Further studies should analyse potential nongenomic effects of testosterone on other forms of social behaviour.

4

Epididymal sperm storage in Rickett's big-footed bat (Myotis ricketti)

100%

Wang Z., Shi Q. X., Wang Y. N., Wang Y. L., Zhang S. Y.

Acta Chiropterologica

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2008

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tom 10

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nr 1

Spermatozoa were present in the cauda epididymidis of male Rickett's big-footed bat, Myotis ricketti, from late September to early April but absent from the testes from mid November until late August. Males thus store spermatozoa in the cauda epididymidis for 4.5–6.5 months of the year. Assessments of sperm motility, movement pattern and computer-assisted sperm analysis (CASA) were carried out on spermatozoa which had been stored for over 3.5 months in the cauda epididymidis. The motility of sperm stored for the same period of time and taken from a male which died over 9 h before assessment was 86%. Four kinds of culture media were screened for their suitability for future studies of sperm motility, and a low calcium minimal capacitation medium and a hamster fertilization medium were selected. Serum testosterone (T) concentration increased dramatically in September and began to fall in October, before returning to baseline for the remainder of winter. These results indicate that high levels of T are required for spermatogenesis and spermiogenesis but not for sperm storage.

5

Year round plasma leptin and androgen concentrations in a tropical bat

100%

Singh U. P., Krishna A., Bhatnagar K. P.

Acta Theriologica

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2007

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tom 52

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nr 2

The detailed reproductive patterns and their associated endocrine characteristics have been documented only for a few species of bats. The objective of this study was to examine seasonal changes in plasma concentrations of leptin and compare it with the changes in body mass, circulating concentrations of testosterone, androstenedione and its correlation with prolonged survival of sperm during winter dormancy in the male sheath-tailed batTaphozous longimanus Hardwicke, 1825. Six bats were captured every month for three consecutive years during 2002 to 2005 from Varanasi, a subtropical part of India. The changes in the body mass were positively correlated with circulating concentration of leptin. Leptin concentration reached a peak (14 ng/ml) in November coinciding with peak body mass. Leptin levels declined during other months of the year except for a rise in March and August. Plasma leptin was positively correlated with androstenedione concentration, but did not show significant correlation with testosterone level. We noticed a significant increase in testosterone secretionin vitro in response to leutinizing hormone (LH) stimulation. However, we did not notice any increase in testosterone or androstenedione secretionin vitro in response to leptin stimulation. Plasma leptin concentration did not show any correlation with testis mass in this study. The higher concentration of testosterone and androstenedione may be responsible for the prolonged survival of sperm in the epididymidies and higher levels of leptin in November may be responsible for maintaining reproductive function during winter dormancy. We suggest that inT. longimanus, higher leptin concentrations in November may be responsible for the gonadal recrudescence and reproductive response during winter dormancy is modified by energy availability and by changing leptin concentrations during this period.

6

Prenatal exposure to anticonvulsant drugs and spatial ability in adulthood

100%

Dessens A., Cohen-Kettenis P., Mellenbergh G., Van de Poll N., Koppe J., Boer K.

Acta Neurobiologiae Experimentalis

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1998

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tom 58

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nr 3

7

Seasonal changes in pineal gland response to exogenous testosterone in male Blossomheaded Parakeet [Psittacula cyanocephala] and Indian Weaver bird [Ploceus philippinus]

100%

Chakraborty S., Sarkar A.

Folia Biologica

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1994

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tom 42

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nr 1-2

8

Morphometric studies on rat epididymis in the course of postnatal development [computerised image analysis]

100%

Limanowski A., Miskowiak B., Otulakowski B., Partyka M., Konwerska A.

Folia Histochemica et Cytobiologica

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2001

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tom 39

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nr 2

9

Administration of testosterone inhibits initiation of seminal tubule growth and decreases Sertoli cell number in the earliest period of rat's postnatal development

84%

Walczak-Jedrzejowska R., Slowikowska-Hilczer J., Marchlewska K., Oszukowska E., Kula K.

Folia Histochemica et Cytobiologica

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2009

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tom 47

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nr 5

10

Influence of oleoyl-estrone treatment on circulating testosterone. Role of 17beta-hydroxysteroid dehydrogenase isoenzymes

84%

Romero M. M., Vila R., Fernandez-Lopez J. A., Esteve M., Alemany M.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 1

181-190

Overweight male rats received oral oleoyl-estrone (OE) for 10 days, and were compared with controls. The expression of 17ß-hydroxysteroid dehydrogenase (17ßHSDH) isoenzymes, and other proteins related to sex hormone metabolism, were analyzed in testicle, liver, adrenals and two white adipose sites: subcutaneous inguinal and epididymal pads using a semiquantitative RT-PCR method. Androstenedione, testosterone, estrone and estradiol levels were measured by HPLC-MS/MS. Isoenzyme expressions were grouped according to their main physiological function (oxidative or reductive) and preferred substrate (androgen or estrogen). As expected, testicle was the main site for synthesis of testosterone and estradiol, and the liver the main organ oxidizing them to androstenedione and estrone. Overall oxidative capacity was 6.5-fold higher than the reductive, and estradiol synthesis and oxidation potential were higher than for testosterone. OE decreased serum androgens, and increased estrone, but not estradiol. This was due to decreased testicle ability to produce testosterone, because of smaller size and decreased 17ßHSDH3 expression, but also to lower availability of precursors. High estrone availability (from OE hydrolysis) does not translate into higher estradiol because of decreased testicle reductive 17ßHSDH expression and decreased aromatase. In consequence, we can assume that OE effects on androgens, and the hypothalamic-pituitary-gonadal axis are limited to testicles.

11

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SRC kinase mRNA transcription changes in testosterone-induced rat ventral prostate lobes under the influence of Epilobium angustifolium extract

84%

Kujawski R., Bartkowiak-Wieczorek J., Bogacz A., Karasiewicz M., Mikolajczak P. L., Czerny B., Mrozikiewicz P. M.

Herba Polonica

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2013

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tom 59

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nr 4

The aim of this study was to investigate the influence of standardized crude aqueous Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of SRC kinase mRNA - a representatives of non-genomics xenobiotics signaling pathway in prostate ventral lobes of testosterone-induced, castrated rats. We have shown that in all analyzed groups induced by testosterone an elevation of SRC kinase mRNA transcription was observed, in comparison to control animals (not receiving the testosterone), (p<0.05). Finasteride in rats induced by testosterone caused the strongest inhibition of SRC mRNA transcription (p<0.05). In rats receiving testosterone and the plant extract a ca. 90% decrease of mRNA level was observed vs. testosterone-induced animals (p<0.05), while in testosterone-induced animals receiving concomitantly E. angustifolium extract and finasteride the observed reduction reached 87.3% (p<0.05). We did not observed, however, any positive feedback between studied plant extract and finasteride in the inhibitory activity (p<0.05). Further experimental studies should be performed in order to the understanding the molecular basis of interactions, the efficacy and safety of tested plant extract.

12

The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat

84%

Narayana K., D'Souza U. J. A., Narayan P., Kumar G.

Folia Morphologica

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2005

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tom 64

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nr 2

65-71

The present study was planned to evaluate the toxic effects of ribavirin on the reproductive parameters in the male Wistar rat. Rats (11–13 weeks old) were treated with 5 injections (i.p.) of 20, 100 or 200 mg/kg/day ribavirin at intervals of 24 h. The testes were processed for histopathological analysis on days 14, 35, 70 and 105 after the last exposure. The parameters studied were body weight, the weights of the testis, epididymis, seminal vesicle and prostate, seminiferous tubular diameter (STD), epithelial height (SE), epithelial sloughing, incidence of stage XIV tubules, sperm abnormality and total serum level of testosterone. Data were analysed by ANOVA and the Bonferroni post hoc test for significances between different groups. There was a decrease in body weight and organ weights, excluding those of the testis and epididymis, against control at higher dose-levels. Ribavirin induced the formation of vacuoles, gaps and sloughing of the seminiferous epithelium. The STD, SE and the incidences of stage XIV tubules decreased on days 14 and 35. Ribavirin also induced the formation of sperm with microcephaly and cephalocaudal junction defects, with or without fibrils jetting out. All these morphological defects recovered to control limit by day 105. The serum level of testosterone was decreased at all dose-levels and time points, although recovery had started by day 105. In conclusion, ribavirin is gonadotoxic in male rats but the effects are reversible after a period of 105 days. However, the endocrine-disrupting properties of ribavirin persist beyond this period.

13

Testicular and blood steroid levels in aged men

84%

Carreau S., Bourguiba S., Marie E.

Reproductive Biology

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2004

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tom 04

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nr 3

14

Anabolic/catabolic index (T/C ratio) in blood of elite rowers in selected periods of an annual training cycle

84%

Basta P., Pilaczynska-Szczesniak L., Skarpanska-Stejborn A., Arlet J.

Studies in Physical Culture and Tourism

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2011

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tom 18

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nr 3

15

Progesterone and androgen secretion by isolated cultured bovine corpus luteum cells: effect of LH, hCG, PRL, estradiol 17beta and testosterone

84%

Gregoraszczuk E.

Folia Histochemica et Cytobiologica

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1985

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tom 23

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nr 1-2

16

Features of gonadal dysgenesis and Leydig cell impairment in testes with Sertoli cell-only syndrome

84%

Adamczewska D., Slowikowska-Hilczer J., Marchlewska K., Walczak-Jedrzejowska R.

Folia Histochemica et Cytobiologica

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2020

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tom 58

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nr 2

17

Changes of interleukin-1beta and testosterone concentration after nonsteroidal anti-inflammatory drug treatment at different times relative to endotoxin administration in an equine model

84%

Danek J., Krumrych W., Golda R.

Folia Biologica

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2017

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tom 65

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nr 2

18

Effect of ostarine (enobosarm/GTx024), a selective androgen receptor modulator, on adipocyte metabolism in Wistar rats

84%

Leciejewska N., Pruszynska-Oszmalek E., Bien J., Nogowski L., Kolodziejski P. A.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 4

19

Pituitary adrenal axis activity in the male Libyan jird, Meriones libycus: Seasonal effects and androgen mediated regulation

84%

Aknoun-Sail N., Zatra Y., Kheddache A., Moudilou E., Khammar F., Exbrayat J.-M., Amirat Z.

Folia Biologica

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2017

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tom 65

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nr 2

20

Expression of testicular angiotensin-converting enzyme in adult spontaneously hypertensive rats

84%

Atanassova N., Lakova E., Bratchkova Y., Krasteva G., Donchev M.

Folia Histochemica et Cytobiologica

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2009

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tom 47

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nr 1

117-122

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