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1

Nerve cells and synapses in the human foetal hypogastric nerves

100%
Bruska M.
Folia Morphologica
|
2005
|
tom 64
|
nr 3
199-211
The hypogastric nerves of a human foetus of 220 mm C-R length (23rd week) were investigated with an electron microscope. These nerves were composed mainly of bundles of unmyelinated fibres and single myelinated fibres. Small ganglia and single ganglion cells were observed in the hypogastric nerves. Light and dark cells were found among the nerve cells. The two types of cell differed in the number of ribosomes and the amount rough endoplasmic reticulum. In the period of development investigated protosynapses and mature synapses were observed in the hypogastric nerves.
2

Morphological and molecular organization of the brain postsynaptic densities

86%
Rysak M., Konecki J., Helewski K.
Folia Morphologica
|
1988
|
tom 47
|
nr 1-4
3
Content available remote

Impact of matrix metalloproteinase-9 overexpression on synaptic excitatory transmission and its plasticity in rat Ca3-Ca1 hippocampal pathway

86%
Wiera G., Szczot M., Wojtowicz T., Lebida K., Koza P., Mozrzymas J. W.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 2
4

The development of synapses in the pyramidal tract at the medullary level in human fetus

86%
Bruska M., Wozniak W.
Folia Morphologica
|
1994
|
tom 53
|
nr 1
5

Two components of long-term memory

86%
Wozniak P. A., Gorzelanczyk E. J., Murakowski J. A.
Acta Neurobiologiae Experimentalis
|
1995
|
tom 55
|
nr 4
6

Targeting of mRNA to postsynaptic sites on neuronal dendrites

72%
Steward O.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
A fundamental aspect of gene expression in neurons involves delivery of certain mRNAs to synaptic sites on dendrites, where they are locally translated at synapses. Local translation of mRNA plays a critical role in synaptic consolidation, the process through which early transient changes in synaptic effi cacy become more enduring. Mechanisms of transport and localization have been revealed through studies of a unique immediate early gene (IEG) called Arc (activity-regulated cytoskeleton-associated protein), AKA Arg 3.1. Arc is strongly induced by intense neuronal activity, but is unique amongst known IEGs because its mRNA is rapidly delivered into dendrites. A remarkable feature of Arc is that newly-synthesized Arc mRNA localizes selectively at active synapses. Live cell imaging studies using a GFP-based labeling system reveal that exogenously expressed Arc constructs assemble into particles that are transported at rates up to 65 μm/minute, which would allow the delivery of an mRNA from the nucleus to synapses on distal dendrites within minutes. Transcripts that contain the 3’UTR of Arc localize in a highly selective manner at the base of dendritic spines, indicating that the signals mediating both dendritic transport and synaptic targeting are present in the 3’UTR of Arc mRNA. Docking of Arc mRNA at active synapses depends on NMDA receptor activation, a rapid polymerization of actin in spines, and local activation of MAP kinase. Continued strong activation of synapses after Arc mRNA is docked at synapses triggers Arc mRNA degradation; the mechanisms underlying this activity-dependent mRNA degradation remain to be identifi ed. I will discuss how this mechanism might play a role in stabilizing changes in synapses induced by activity.
7

Electrophysiological characterization of synaptic connections of neurons of the thalamic reticular nucleus

72%
Ulrich D.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 5
8

Short-term plasticity at synapses in the thalamic reticular nucleus: implications for a thalamic mechanism of selective attention

72%
Crabtree J. W.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 5
9

Brain spectrin and friends

72%
Riederer B. M., Wintergerst E. S., Valcourt E., Routtenberg A.
Cellular and Molecular Biology Letters
|
1996
|
tom 01
|
nr 1
Brain spectrin (fodrin, calspectin), is an actin binding protein, and composed of two α- and two β-subunits which combine by head-to-head interaction to a heterotetramere. Together with other proteins it forms a proteinaceous meshwork underlying the cytoplasmic surface of the plasma membrane. In the mammalian brain, three forms of spectrins were identified, an axonal, a somato-dendritic and a astroglial one. A subcellular localization at the electron microscopic-level suggests that these forms are not only attached to membranes but expand into the cytoplasm. It was shown that they differ in their subcellular distribution, and their temporal appearance during postnatal brain development. The subplasmalemmal cytoskeleton is composed of brain spectrin and a variety of proteins such as actin and calmodulin, and we discuss here two additional proteins, FI and parvalbumin, which may bind to brain spectrin and may have to be included in the circle of proteins interacting with brain spectrin.
10

Development of the tongue and taste discs in Pelobates fuscus

72%
Zuwala K.
Folia Biologica
|
2002
|
tom 50
|
nr 3-4
11

Isoforms distribution and activities of beta spectrins and 4.1 proteins in brain

72%
Baines A. J., Bignone P. A., Hayes N. V. L., Keating L. A., Phillips G. W., Scott C.
Cellular and Molecular Biology Letters
|
2001
|
tom 06
|
nr 2
12

Levetiracetam protects hippocampal neurons in culture against hypoxia-induced injury

58%
Sendrowski K., Bockowski L., Sobaniec W., Ilendo E., Jaworowska B., Smigielska-Kuzia J.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 1
13

The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM functions

58%
Hortsch M., Nagaraj K., Godenschwege T. A.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 1
57-69
L1-type cell adhesion molecules (CAMs) are important mediators of neural differentiation, including axonal outgrowth and pathfinding and also of synapse formation and maintenance. In addition, their interactions with cytoskeletal components are highly conserved and regulated. How these different aspects of CAM functionality relate to each other is not well understood. Based on results from our and other laboratories we propose that ankyrin-binding to L1-type CAMs provides a master switch. The interaction with ankyrins directs L1-type adhesive proteins into different functional contexts, either ankyrin-independent functions, such as neurite outgrowth and axonal pathfinding or into ankyrin-dependent functions, such as L1’s role at axon initial segments (AIS), paranodal regions, synapses and in dendrites.
14
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Content available

Gamma-secretase complex in plant cells

58%
Skrzypczak T., Smolarkiewicz M., Wojtaszek P.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
|
tom 94
|
nr 3
15

Synantocytes: the fifth type of glia? In comparison with astrocytes

58%
Krawczyk A., Jaworska-Adamu J.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 2
173-177
16

Ultastructure of the ventral lateral geniculate nucleus [LGNv] receiving tectal afferents in the cat

58%
Noseworthy M. D., Partlow G. D.
Acta Neurobiologiae Experimentalis
|
1992
|
tom 52
|
nr 2
17

L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol stimulates ganglioside biosynthesis, neurite outgrowth and synapse formation in cultured cortical neurons, and ameliorates memory deficits in ischemic rats

58%
Inokuchi J., Kuroda Y., Kosaka S., Fujiwara M.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 2
To address the role of brain gangliosides in synaptic plasticity, the synthetic ceramide analog, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) was used to manipulate the biosynthesis of gangliosides in cultured cortical neurons. Spontaneous synchronized oscillatory activity of intracellular Ca2+ between the neurons, which represents synapse formation, was suppressed by the depletion of endogenous gangliosides by D-threo-PDMP, an inhibitor of glucosylceramide synthase. The decreased functional synapse formation was normalized by supplementation of GQ1b but not by the other gangliosides, suggesting that de novo synthesis of ganglioside GQ1b is essential for the synaptic activity (Mizutani A. et al., Biochem. Biophys. Res. Commun. 222, 494-498, 1996). On the other hand, the enantiomer of the inhibitor, L-threo-PDMP, could elevate cellular levels of glycosphingolipids including gangliosides. This paper presents our recent findings on the neurotrophic actions of L-threo-PDMP in vitro and in vivo. We found that L-PDMP could up-regulate neurite outgrowth, functional synapse formation and ganglioside biosynthesis through activating GM3, GD3 and GQ1b synthases. Simultaneously, the activity of p42 mitogen-activated protein kinase was also facilitated by L-PDMP. To evaluate the efficacy of this drug on long term memory, rats were trained for 2 weeks using an 8-arm radial maze task, and then forebrain ischemia was induced by 4-vessel occlusion (for 10 min × 2 with a 60 min interval). Repeated treatment of L-threo-PDMP (40 mg/kg, i.p. for 6 days, twice a day) starting 24 h after the ischemia, improved the deficit of the well-learned spatial memory, demonstrating the potential therapeutic use of the ceramide analog for treatment of neurodegenerative disorders.
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