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1

Molecular modeling of selected magnesium organic salts. Structure - activity relationship

100%
Marcoin W.
Journal of Elementology
|
2005
|
tom 10
|
nr 4 Suppl.1
67
2

Synthesis, structure activity relationship and mode of action of insect pheromones. A contribution to the problem of chemical information among insects

88%
Bestmann H. J., Vostrowsky O.
Pestycydy
|
1990
|
nr 1
3

Review of methods applied to search structure-activity relationship

88%
Wilkowska E., Golebiewski W. M.
Pestycydy
|
2001
|
nr 1-2
4

HPLC-online TEAC - antioxidant activity of single compounds in complex mixtures

75%
Zietz M., Schmidt S., Rohn S., Schreiner M., Krumbein A., Kroh L. W.
Polish Journal of Food and Nutrition Sciences
|
2011
|
tom 61
|
nr Suppl.1
5

Structural studies of cysteine proteases and their inhibitors

75%
Grzonka Z., Jankowska E., Kasprzykowski F., Kasprzykowska R., Lankiewicz L., Wiczk W., Wieczerzak E., Ciarkowski J., Drabik P., Janowski R., Kozak M., Jaskolski M., Grubb A.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 1
Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to dis­cuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding frag­ments of cystatins.
6

Biological studies on pesticidal activity of aniline and [R]-2-phenoxypropionic acid derivatives

75%
Ziminska Z., Krawczyk M., Ptaszkowska J., Ejmocki Z., Ochal Z., Gajadhur A., Mizerski A.
Pestycydy
|
2001
|
nr 1-2
7

Interactions of antitumour triazoloacridinones with DNA

75%
Koba M., Konopa J.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr 2
Triazoloacridinones (TA) are a new group of potent antitumor compounds, from which the most active derivative, C-1305, has been selected for extended preclinical trials. This study investigated the mechanism of TA binding to DNA. Initially, for selected six TA derivatives differing in chemical structures as well as cytotoxicity and antitumor activity, the capability of noncovalent DNA binding was analyzed. We showed that all triazoloacridinones studied stabilized the DNA duplex at a low-concentration buffer but not at a salt concentration corresponding to that in cells. DNA viscometric studies suggested that intercalation to DNA did not play a major role in the mechanism of the cytotoxic action of TA. Studies involving cultured cells revealed that triazoloacridinone C-1305 after previous metabolic activation induced the formation of interstrand crosslinks in DNA of some tumor and fibroblast cells in a dose dependent manner. However, the detection of crosslink formation was possible only when the activity of topoisomerase II in cells was lowered. Furthermore, it was impossible to validate the relevance of the ability to crosslink DNA to biological activity of TA derivatives.
8
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Content available

Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast

63%
Hoshi T., Yamada K., Yoshizawa Y., Oh K.
Journal of Plant Protection Research
|
2015
|
tom 55
|
nr 4
To explore new antifungal agents for rice blast control, the antifungal activity of a series of novel 1,2,4-triazole derivatives against Magnaporthe oryzae has been evaluated. The antifungal activity was determined by using in vitro mycelial growth inhibition tests. Among the 19 test compounds, we found that the compound 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4- triazole (Gj) displayed potent antifungal activity against M. oryzae. The IC50 value was found approximately 3.8±0.5 μM and the IC50 value of propiconazole was found to be approximately 3.7±0.2 μM, respectively. Structure-activity relationship studies on aromatic ring structures provided insight and information about the structural requirements for antifungal activity of this synthetic series against M. oryzae.
9

Studies on herbicidal efficacy of 5-difluoro- and trifluoromethylsulfonylbenzoimidazoles

63%
Krawczyk M., Ziminska Z., Zalecki S., Ejmocki Z., Legowiak Z., Ochal Z., Mizerski A.
Pestycydy
|
2001
|
nr 1-2
10

Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1

51%
Wesolowska O.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
Multidrug resistance (MDR) of cancer cells poses a serious obstacle to successful chemotherapy. The overexpression of multispecific ATP-binding cassette transporters appears to be the main mechanism of MDR. A search for MDR-reversing agents able to sensitize resistant cells to chemotherapy is ongoing in the hope of their possible clinical use. Studies of MDR modulators, although they have not produced clinically beneficial effects yet, may greatly enrich our knowledge about MDR transporters, their specificity and mechanism of action, especially substrate and/or inhibitor recognition. In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed. Each group of compounds is likely to interact with the MDR transporters by a different mechanism. Phenothiazines probably interact with drug binding sites, but they also could indirectly affect the transporter's activity by perturbing lipid bilayers. Flavonoids mainly interact with ABC proteins within their nucleotide-binding domains, though the more hydrophobic flavonoids may bind to regions within transmembrane domains. The possible mechanism of MDR reversal by stilbenes may result from their direct interaction with the transporter (possibly within substrate recognition sites) but some indirect effects such as stilbene-induced changes in gene expression pattern and in apoptotic pathways should also be considered. Literature data as well as some of our recent results are discussed. Special emphasis is put on cases when the interactions of a given compound with both P-glycoprotein and MRP1 have been studied simultaneously.
11

New biological activity of NPF-related peptides in insects

51%
Skonieczna M., Grodecki S., Konopinska D., Rosinski G.
Pestycydy
|
2005
|
nr 4
91-98
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effect of farnesol and its synthetic derivatives on the settling behaviour of the peach potato aphid Myzus persicae (Sulz.)

51%
Dancewicz K., Gliszczynska A., Halarewicz A., Wawrzenczyk C., Gabrys B.
Pestycydy
|
2010
|
nr 1-4
The behavioural effect of trans,trans-farnesol and its structural derivatives on M. persicae was evaluated. The incorporation of carboxy group into the molecule did not alter the strong deterrent activity of farnesol. The lactonization and the epoxidation of farnesol caused the delay in expression and the loss of deterrent activity, respectively. The ester, product of Claissen rearrangement of farnesol and iodolactone did not exhibit significant biological effect.
13

Synthesis and biological effects of insect oostatic peptide Neb-colloostatin

51%
Kuczer M., Skonieczna M., Wasielewski O., Rosinski G., Konopinska D.
Pestycydy
|
2005
|
nr 3
39-47
14

Structure-activity relationships for insect kinins on expressed receptors from a tick [Acari: Ixodidae] and a mosquito [Diptera: Culicidae]

51%
Taneja-Bageshwar S., Strey A., Zubrzak P., Pietrantonio P. V., Nachman R. J.
Pestycydy
|
2005
|
nr 3
55-59
15

The importance of natural products in insect control

38%
Ujvary I.
Pestycydy
|
2005
|
nr 3
21-37
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