Wyniki wyszukiwania

1

Lipids and signal transduction in the nucleus

100%

Dygas A., Baranska J.

Acta Biochimica Polonica

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2001

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tom 48

|

nr 2

During the last few years a growing amount of data has accumulated showing phospholipid par tic i pa tion in nu clear sig nal transduction. Very re cent data strongly sup port the hy poth e sis that sig nal transduction in the nu cleus is au to nomic. Lo cal pro duc tion of inositol polyphosphates, be gin ning with the ac ti va tion of phospholipase C is required for their specific function in the nucleus. Enzymes which modify poly- phosphoinositols may control gene expression. Much less information is available about the role of other lipids in nuclear signal transduction. The aim of this minireview is to stress what is cur rently known about nu clear lipids with re spect to nu clear sig nal transduction.

2

Caged regulators of signaling pathways

100%

Lawrence D. S., Wood J., Curley K.

Cellular and Molecular Biology Letters

|

1998

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tom 03

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nr 3

3

The emerging distinct role of TNF-receptor 2 [p80] signalling in chronic inflammatory disorders

100%

Holtmann M. H., Schuchmann M., Zeller G., Galle P. R., Neurath M. F.

Archivum Immunologiae et Therapiae Experimentalis

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2002

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tom 50

|

nr 4

4

Negative signals from FcepsilonRI engagement attenuate mast cell functions

100%

Molfetta R., Peruzzi G., Santoni A., Paolini R.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

|

nr 4

5

Dissecting the functions of protein tyrosine phosphatases using chemical approaches

100%

Zhang Z. Y.

Cellular and Molecular Biology Letters

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2005

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tom 10

|

nr Suppl.2

6

Participation of integrin receptors in signal transduction of contact inhibited C3H10T1-2 cells

100%

Miloszewska J., Janik P.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 2

7

Crosstalk between G protein-coupled receptors and tyrosine kinase signalling; Src take centre stage

100%

Ptasznik A., Gewirtz A. M.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

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tom 48

|

nr 1

8

The influence of aging in one tauopathy: Alzheimer's disease

88%

Avila J.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

|

nr 6

9

Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates

88%

Li M., Becnel L. S., Li W., Fisher W. E., Chen C., Yao Q.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

|

nr 5

10

Differential regulation of signalling pathways for insulin and insulin-like growth factor I

88%

Lopaczynski W.

Acta Biochimica Polonica

|

1999

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tom 46

|

nr 1

The insulin receptor (IR) and the insulin-like growth factor receptor I (IGF-IR) have different functions in cell growth, apoptosis, differentation, and transformation. Although some of these differences may be explained by the relative level of receptor expression and receptor structure (a and b subunits), they may also be attributed to differences in intracellular signals generated by insulin and IGF-I. The presence of hybrid receptors (IR ab subunits and IGF-IR ab subunits) making up the heterotetramers has added a new dimension to our understanding of the functional roles of these receptors. However, to date the results of efforts to understand the differences between these two closely related receptors have indicated mostly similarities. For example, both receptors utilize IRS-1/IRS-2 and Shc as immediate downstream adaptors, leading to activation of the Ras, Raf, ERK kinases and PI-3 kinase pathways. We have used the yeast two hybrid system to identify proteins which bind to the activated IGF-IR but not to the IR. The cytoplasmic domain of the IGF-IR was used to screen a human fetal brain library and two isoforms of the 14-3-3 family were identified. 14-3-3 proteins are a highly conserved family of proteins which have recently been shown to interact with other components of the mitogenic and apoptotic signaling pathways, including Raf, BAD, Bcr/Bcr-Abl, middle-T antigen, Ksr, PKC, PI-3 kinase, ASK1 kinase, and cdc25C phosphatase. We also identified human Grb10, an adaptor protein with SH2 domain associated with the IGF-IR b subunit. Smith's laboratory showed that Grb10 preferentially binds to the IR in intact cells. Using the interaction trap screen (active cytoplasmic domain of the IGF-IR) 55PIK and SOCS-2 proteins were also identified. However, 55PIK and SOCS-2 also interact with the IR in the yeast two hybrid system. These studies raise the possibility that 14-3-3 and Grb10 may play a role in insulin and IGF-I signal transduction and may underlie the observed differences.

11

On the role of spectrin and spectrin SH3 domain in integrin-induced signalling

88%

Bialkowska K., Fox J. E. B.

Cellular and Molecular Biology Letters

|

2001

|

tom 06

|

nr 2

12

Alternative binding modes of proline-rich peptides binding to the GYF domain

88%

Gu W., Kofler M., Antes I., Freund C., Helms V.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr Suppl.2

13

Escape from contact inhibition as a result of signal transduction disorder

88%

Janik P., Miloszewska J., Przybyszewska M.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

14

Peptide micro-arrays for kinase profiling

88%

Schutkowski M., Reimer U., Panse S., Dong L., Schneider-Mergener J.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 2A

15

Heterogeneous nuclear ribonucleoprotein [hnRNP] K protein as a docking platform, and its role in cellular signalling

88%

Ostrowski J.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

16

Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells

88%

Dygas A., Sidorko M., Bobeszko M., Baranska J.

Acta Biochimica Polonica

|

1999

|

tom 46

|

nr 1

In the present study we investigate the effect of exogenous sphingosine, sphingosine 1-phosphate and sphingosylphosphorylcholine on phospholipase D (PLD) activity in glioma C6 cells. The cells were prelabeled with [1-14C]palmitic acid and PLD-mediated synthesis of [14C]phosphatidylethanol was measured. Sphingosine 1-phosphate and sphingosylphosphorylcholine did not stimulate [14C]phosphatidyl-ethanol formation either at low (0.1-10 μM) or high (25-100 μM) concentrations. On the other hand, sphingosine at concentrations of 100-250 μM strongly stimulated PLD activity as compared to the effect of phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), known as a PLD activator. The effect of TPA on PLD is linked to the activation of protein kinase C. The present study also shows that sphingosine additively enhances TPA-mediated PLD activity. This is in contrast to the postulated role of sphingosine as a protein kinase C inhibitor. These results demonstrate that in glioma C6 cells sphingosine not only affects PLD independently of its effect on protein kinase C, but also is unable to block TPA-mediated PLD activity.

17

Gelsolin and related proteins in vertebrate model organisms

75%

Migocka-Patrzalek M., Niedbalska-Tarnowska J., Garbiec A., Dubinska-Magiera M., Daczewska M.

Folia Biologica

|

2019

|

tom 67

|

nr 4

18

The role of calcium in signal transduction processes in Sertoli cells

75%

Gorczynska-Fjalling E.

Reproductive Biology

|

2004

|

tom 04

|

nr 3

19

Study on the activity of the signaling pathways regulating hepatocytes from G0 phase into G1 phase during rat liver regeneration

75%

Li M., Zhou X., Mei J., Geng X., Zhou Y., Zhang W., Xu C.

Cellular and Molecular Biology Letters

|

2014

|

tom 19

|

nr 2

Under normal physiological conditions, the majority of hepatocytes are in the functional state (G0 phase). After injury or liver partial hepatectomy (PH), hepatocytes are rapidly activated to divide. To understand the mechanism underlying hepatocyte G0/G1 transition during rat liver regeneration, we used the Rat Genome 230 2.0 Array to determine the expression changes of genes, then searched the GO and NCBI databases for genes associated with the G0/G1 transition, and QIAGEN and KEGG databases for the G0/G1 transition signaling pathways. We used expression profile function (E t ) to calculate the activity level of the known G0/G1 transition signal pathways, and Ingenuity Pathway Analysis 9.0 (IPA) to determine the interactions among these signaling pathways. The results of our study show that the activity of the signaling pathways of HGF, IL-10 mediated by p38MAPK, IL-6 mediated by STAT3, and JAK/STAT mediated by Ras/ERK and STAT3 are significantly increased during the priming phase (2–6 h after PH) of rat liver regeneration. This leads us to conclude that during rat liver regeneration, the HGF, IL-10, IL-6 and JAK/STAT signaling pathways play a major role in promoting hepatocyte G0/G1 transition in the regenerating liver.

20

Differential effects of heterocyclic amines on poly[ADP-ribose] polymerase-1 and mono-ADP-ribosyltransferase A

75%

Banasik M., Stedeford T., Strosznajder R. P., Hsu C.-H., Tanaka S., Ueda K.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

15-22

Heterocyclic amines (HCAs) have been shown to be carcinogenic in a variety of experimental systems. The purpose of the present study was to determine the in vitro effect of HCAs on the activity of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1). HCAs were also tested on the arginine-specific mono-ADP-ribosyltransferase A (MART-A), an enzyme involved in signal transduction and cytoskeletal realignment. 3-Amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) at 1 mM caused a 134% increase in PARP-1 activity and a 93% decrease in activity at 5 mM (IC50 = 2.2 mM). This dual effect is unique among inhibitors of this enzyme. On the other hand, Trp-P-2 activated MART-A at all concentrations tested, the peak being at 3 mM (>171% increase). In contrast, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) inhibited concentration-dependently both enzymes, PARP-1 (IC50 = 0.22 mM) and MART-A (IC50 = 2.8 mM). With nine other HCAs tested, predominantly inhibitory effects were observed. These results may assist our understanding of the carcinogenic mechanism of action and the dose-dependency of HCAs in animal bioassays.

Ograniczanie wyników

Lipids and signal transduction in the nucleus

Caged regulators of signaling pathways

The emerging distinct role of TNF-receptor 2 [p80] signalling in chronic inflammatory disorders

Negative signals from FcepsilonRI engagement attenuate mast cell functions

Dissecting the functions of protein tyrosine phosphatases using chemical approaches

Participation of integrin receptors in signal transduction of contact inhibited C3H10T1-2 cells

Crosstalk between G protein-coupled receptors and tyrosine kinase signalling; Src take centre stage