Wyniki wyszukiwania

1

Exclusion of four candidate kidney disease loci by linkage analysis in familial juvenile hyperuricaemic nephropathy [FJHN]

100%

Greener M., Marinaki A. M., Town M. M., Moro F., Simmonds H. A., Cameron J. S., Duley J. A., Mathew C.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

2

Renal interstitial mast cell counts differ across classes of proliferative lupus nephritis

86%

Kaczmarczyk K., Kosalka J., Soja J., Kuzniewski M., Musial J., Okon K.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 3

3

Familial juvenile hyperuricaemic nephropathy [FJHN] in three Czech families

86%

Stiburkova B., Pospisilova E., Paterova T., Krijt J., Kumsta M., Sebesta I., Kmoch S.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

4

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HI antibody kinetics in children with renal failure immunized with inactivated trivalent influenza vaccine

86%

Brydak L. B., Roszkowska-Blaim M., Leszczynska B., Rudnicka H.

Bulletin of the Veterinary Institute in Puławy

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1998

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tom 42

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nr 1

5

Essential edema-proteinuria-hypertesion [EPH] gestosis and gestosis superimposing pre-existing renal disease: comparison of cellular immunity parameters

86%

Malinowski A., Szpakowski M., Tchorzewski H., Zeman K., Oszukowski P., Podciechowski L.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 5-6

6

Targeting the chemokine network in renal inflammation

86%

Eis V., Vielhauer V., Anders H. J.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 3

7

Are killer cell immunoglobulin-like receptor genes important for the prediction of kidney graft rejection?

72%

Kusnierczyk P.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 4

8

Prevalence of sleep apnea syndrome in hemodialyzed patients with end-stage renal disease

72%

Miskowiec I., Klawe J. J., Tafil-Klawe M., Jeske K., Laudencka A., Bielicka B., Manitius J., Zlomanczuk P.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

207-211

The majority of hemodialyzed patients suffer from sleep disturbances. In the present study the prelevence of sleep apnea syndrome in hemodialyzed patients with end-stage renal disease (ESRD-patients) was investigated by the survey, Epworth Sleepiness Scale (ESS), and polysomnography (PSG). Sixty-one patients: 24 women and 37 men were involved in the study. All subjects participated in the first part of the study consisting of the survey and ESS. The second and third parts consisted of nighttime PSG, performed the night after hemodialysis (17 patients) and between hemodialyses (11 patients). Eleven out of the 61 patients had the symptoms of sleep apnea and heavy daily sleepiness. Eleven subjects were involved in the double PSG study: after and between hemodialyses. Obstrucive sleep apnea was found in 7 of those patients during both nights analyzed. Our results confirm the occurrence of sleep disorders in ESRD-patients. Hemodialysis does not change the prevalence of obstructive sleep apnea in chronic renal disease.

9

Urinary proteomic strategies in biomarkers discovery of renal diseases

72%

Ciechanowicz A. K., Ozgo M., Herosimczyk A., Kurpinska A., Klonowska A., Lepczynski A., Stanski L. R.

Journal of Pre-Clinical and Clinical Research

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2011

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tom 05

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nr 1

10

Changes in renal autacoids in aged human hypertensives

72%

Ungar A., Cristofari C., Torrini M., Di Serio C., Cantini C., Vallotti B., La Cava G., Castellani S., Masotti G.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 4,1

11

The complement cascade and renal disease

58%

Koscielska-Kasprzak K., Bartoszek D., Myszka M., Zabinska M., Klinger M.

Archivum Immunologiae et Therapiae Experimentalis

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2014

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tom 62

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nr 1

12

Aberrant function and differentiation of monocytes in end stage renal disease

58%

Laudanski K., Nowak Z.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

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nr 6

13

Determinants of plasma homocysteine in coal miners

58%

Mungan A. G., Can M., Kiran S., Acikgoz S., Guven B.

Acta Biochimica Polonica

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2013

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tom 60

|

nr 3

Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.

14

The endothelial cell markers von Willebrand factor [vWF], CD31 and CD34 are lost in glomerulonephritis and no longer correlate with the morphological indices of glomerular sclerosis, interstitial fibrosis, activity and chronicity

58%

Gluhovschi C., Gluhovschi G., Potencz E., Herman D., Trandafirescu V., Petrica L., Velciov S., Bozdog G., Bob F., Vernic C., Cioca D.

Folia Histochemica et Cytobiologica

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2010

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tom 48

|

nr 2

230-236

15

Activity of selected aromatic amino acids in biological systems

51%

Krzysciak W.

Acta Biochimica Polonica

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2011

|

tom 58

|

nr 4

Besides the structural function in proteins, aromatic amino acids are precursors of many important biological compounds essential for normal functioning of the human organism. Many of these compounds may be used as markers for identification of specific pathological states. Comprehensive knowledge about the metabolism of aromatic amino acids and mechanisms of action of their metabolites made it possible to develop effective treatments for many disorders. However, it should not be forgotten that in some pathological conditions, these compounds could not only be involved in the pathogenesis of many disease entities but could also be used as an important tool in prediction of many diseases. This paper contains a review of published literature on aromatic amino acids in the context of physiological processes of the human body and chosen social disorders, such as cancers; psychiatric disorders: depression, anxiety states, schizophrenia, bipolar affective disorders; neurodegenerative, and cardiovascular diseases; chronic kidney insufficiency or diabetes.

16

Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-gamma)

51%

Miana M., De Las Heras N., Rodriguez C., Sanz-Rosa D., Martin-Fernandez B., Mezzano S., Lahera V., Martinez-Gonzalez J., Cachofeiro V.

Journal of Physiology and Pharmacology

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2011

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tom 62

|

nr 1

Several factors, including mineralocorticoids, have been implicated in the renal damage associated with hypertension. Peroxisome proliferator activated receptor gamma (PPAR-) agonists improve renal damage associated with different pathologies. Therefore, our hypothesis was that mineralocorticoid receptor blockade ameliorates renal damage associated with hypertension and that this improvement may be mediated by PPAR-. Spontaneously hypertensive rats (SHR) were treated with either vehicle or eplerenone, a mineralocorticoid receptor antagonist, at two different doses: 30 and 100 mg/kg/day for 10 weeks. Age-matched Wistar Kyoto rats (WKY) were used as a normotensive reference group. SHR showed tubulointersticial fibrosis and mild tubular atrophy. These alterations were accompanied by increases in renal cortex gene expression of transforming growth factor beta (TGF-ß) connective tissue growth factor (CTGF) and phosphorylated Smad2 protein levels, factors involved in the fibrotic response. Interleukin 1-beta (IL-1ß) and tumor necrosis factor alpha (TNF-) gene expression were also increased. By contrast, lysyl oxidase (LOX) expression and PPAR- protein levels were decreased in SHR as compared with normotensive animals. Only the high dose of eplerenone was able to reduce blood pressure and partially prevent LOX down-regulation in SHR. Both eplerenone doses significantly ameliorated interstitial fibrosis and tubular atrophy, reduced TGF-ß, CTGF and cytokine gene expression, and decreased Smad2 activation, while normalizing PPAR- protein levels. Conclusions: Mineralocorticoid receptor activation participates in hypertension-associated renal damage. This effect seems to involve stimulation of both fibrotic and inflammatory processes mediated (at least in part) by a down-regulation of PPAR- that can favour an up-regulation of the TGF-ß/Smad signalling pathway.

Ograniczanie wyników

Exclusion of four candidate kidney disease loci by linkage analysis in familial juvenile hyperuricaemic nephropathy [FJHN]

Renal interstitial mast cell counts differ across classes of proliferative lupus nephritis

Familial juvenile hyperuricaemic nephropathy [FJHN] in three Czech families

HI antibody kinetics in children with renal failure immunized with inactivated trivalent influenza vaccine

Essential edema-proteinuria-hypertesion [EPH] gestosis and gestosis superimposing pre-existing renal disease: comparison of cellular immunity parameters

Targeting the chemokine network in renal inflammation

Are killer cell immunoglobulin-like receptor genes important for the prediction of kidney graft rejection?

Prevalence of sleep apnea syndrome in hemodialyzed patients with end-stage renal disease

Urinary proteomic strategies in biomarkers discovery of renal diseases

Changes in renal autacoids in aged human hypertensives

The complement cascade and renal disease

Aberrant function and differentiation of monocytes in end stage renal disease

Determinants of plasma homocysteine in coal miners

The endothelial cell markers von Willebrand factor [vWF], CD31 and CD34 are lost in glomerulonephritis and no longer correlate with the morphological indices of glomerular sclerosis, interstitial fibrosis, activity and chronicity

Activity of selected aromatic amino acids in biological systems

Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-gamma)