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In 2006 and early 2007, three major infectious diseases occurred in various parts of the world. The first was the continuation in some countries of the highly pathogenic avian influenza (HPAI), due to virus subtype H5N1. The second was the first documented expansion of bluetongue (BT) in the northern hemisphere reaching a latitude as high as 52°36’41” N. The third was the reoccurrence of foot and mouth disease (FMD) in certain areas of the world. In 2006 a total of 47 countries: Africa (8), Asia (15) and Europe (24), reported HPAI outbreaks due to H5N1. This paper contains details about the global epidemic situation of this disease. The first occurrence of BT in August 2006 in the Netherlands and afterwards in other Northern European countries was related to climate changes in the direction of the greenhouse effect, enabling the colonization of this region by different Culicoides species being vectors of BT virus. The epizootic situation of this disease, particularly in Northern Europe, was characterized. FMD continued to be a major epizootic disease in the Middle East and was difficult to control because of the traditional large-scale movements of animals in this region. The article also mentions other countries where FMD was diagnosed in 2006 and 2007 such as Turkey, East Amman. Israel, the Palestinian Autonomous Territories, Egypt, Botswana, Guinea, South African Republic, Democratic People’s Republic of Korea, People’s Republic of China, Vietnam, Ecuador, Argentina, Brazil and Bolivia, and identifies its serotypes.
Foot-and-mouth disease virus (FMDV), in contrast to the antigen used for the production of FMD vaccine, can replicate in animals. As a result of infection the specific antibody to the viral structural proteins (SPs) and non-structural proteins (NSPs) of FMDV are synthesized. The laboratory diagnostic methods based on individual NSPs, e.g. 3D, 2C and 2B, as well as polypeptides, such as 3AB and 3ABC can be used for differentiation of infected and vaccinated animals (DIVA). This article presents the aim, principle, methods and results of applying DIVA strategy in the eradication of foot-and-mouth disease. The marker vaccines which enable differentiation between infected and vaccinated animals and appropriate ELISA serological tests for detection of antibodies to the NSPs of FMDV have been described. DIVA strategy makes it possible to reduce the economic losses and restore possibilities of international trade in animals and animal products. This strategy may be an alternative of the administrative “stamping-out” eradication method. The essential aim of DIVA strategy is realization of the so-called “vaccinate-to-live” policy, which is based on the principle that vaccinated animals exposed to FMDV will not transmit the virus. These animals are not epidemiologically risky, and therefore do not have to be eliminated. It is necessary to develop new vaccines and improve those already used as well as the application of reliable diagnostic tests to detect FMDV in vaccinated livestock populations.
The article reviews the history, present status and the future of foot and mouth disease (FMD) vaccine banks in Europe. FMD vaccine banks are those holding reserves of fully formulated and tested vaccines ready for use, and those holding reserves of tested inactivated and concentrated antigen that can be formulated into vaccine. There are essentially four types of FMD vaccine banks in Europe: the International Vaccine Bank (IVB), the European Union Vaccine Bank (EUVB), the All Russian Research Institute for Animal Health (ARRIAH) Vaccine Bank and twelve National Government Vaccine Banks (NGVB). The establishing of these banks, their current location, consistent FMD virus serotypes and strains, as well as their utilization have been summarized. The most recent recommendations on FMD virus strains to be included in FMD vaccines banks, based on current epidemiological intelligence, have been presented. The turnover and replacement of banked antigen is necessary due to changes of FMD epidemiological situation. In an era of increasing global risk of the spread of FMD, vaccine banks will have a strategic role in the control and eradication of FMD.
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