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  1. 7 Cellular and Molecular Biology Letters

  2. 5 Journal of Physiology and Pharmacology

  3. 3 Journal of Physiology and Pharmacology. Supplement

  4. 2 Bulletin of the Veterinary Institute in Puławy

  5. 2 Polish Journal of Food and Nutrition Sciences

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  1. 2 Konturek S. J.

  2. 1 Abnous K.

  3. 1 Ahmed E. A.

  4. 1 Alaca N.

  5. 1 Antonopoulou S.

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  1. 1 2021

  2. 1 2019

  3. 1 2018

  4. 1 2016

  5. 1 2015

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1

Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect

100%
Jaromin A., Zarnowski R., Kozubek A.
Cellular and Molecular Biology Letters
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2006
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tom 11
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nr 3
In our previous study, we developed very stable formulations of submicron oil-in-water emulsions from Adenanthera pavonina L. (family Leguminosae, subfamily Mimosoideae) seed oil, stabilised with soybean lecithin (SPC). Continuing our research, we introduced an additional co-emulsifier, Tween 80, to those formulations in order to decrease the size of the emulsion particles and improve their stability. Formulations with a mean particle size ranging from 43.6 to 306.5 nm and a negative surface charge from −45.3 to −28.5 mV were obtained. Our stability experiments also revealed that most of the tested formulations had a very good degree of stability over a 3-month storage period, both at 4°C and at room temperature. Since many intravenous injectable drugs exhibit lytic activity against erythrocytes, we examined this activity for the emulsion form of cardol, a natural compound with already proven hemolytic properties. The incorporation of this agent into the emulsion caused an evident decrease in hemolytic activity (97–99%). This highly protective effect, observed against sheep erythrocytes, was independent of both the composition and the particle size of the emulsions used. Our studies suggest that nonionic surfactant/phospholipid-based emulsions containing this edible oil of A. pavonina L. may be useful as an alternative formulation matrix for pharmaceutical, nutritional or cosmetic applications of otherwise membrane-acting components.
2
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Content available

UV-B induced oxidative stress and protective effects of NO under myo-inositol-deficient background in Arabidopsis

86%
Lytvyn D., Bergounioux C., Yemets A., Blume Y.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2013
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tom 94
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nr 2
3

Spectroscopic studies on the protective effect of a specific sugar on concanavalin A at acidic, neutral and alkaline pH

86%
Khan R. H., Naeem A., Baig M. A.
Cellular and Molecular Biology Letters
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2005
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tom 10
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nr 1
4

Novel adenosine deaminase inhibitors and their cytoprotective effects

86%
Barankiewicz J.
Cellular and Molecular Biology Letters
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1999
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tom 04
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nr 3
5

Protective effect of crocin on acrolein-induced tau phosphorylation in the rat brain

72%
Rashedinia M., Lari P., Abnous K., Hosseinzadeh H.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr 2
Acrolein, as a by-product of lipid peroxidation, is implicated in brain aging and in the pathogenesis of oxidative stress-mediated neurodegenerative disorders such as Alzheimer's disease (AD). Widespread human exposure to the toxic environmental pollutant that is acrolein renders it necessary to evaluate the effects of exogenous acrolein on the brain. This study investigated the toxic effects of oral administration of 3 mg/kg/day acrolein on the rat cerebral cortex. Moreover, the neuroprotective effects of crocin, the main constituent of saffron, against acrolein toxicity were evaluated. We showed that acrolein decreased concentration of glutathione (GSH) and increased levels of malondialdehyde (MDA), Amyloid-P (AP) and phospho-tau in the brain. Simultaneously, acrolein activated Mitogen-Activated Protein Kinases (MAPKs) signalling pathways. Co-administration of crocin significantly attenuated MDA, AP and p-tau levels by modulating MAPKs signalling pathways. Our data demonstrated that environmental exposure to acrolein triggers some molecular events which contribute to brain aging and neurodisorders. Additionally, crocin as an antioxidant is a promising candidate for treatment of neurodegenerative disorders, such as brain aging and AD.
6
Content available remote

Protective effects of L-carnitine on reproductive capacity in rats with diabetes

72%
Li X.-F., Shi Z.-D., Song H., Wang Y.-L., Li Q.-C., Diao X.-H., Pang Y.-W., Zhou S.-H., Liu H.-Y.
Journal of Physiology and Pharmacology
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2021
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tom 72
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nr 1
7

Evaluation of the protective effect of a prime-boost strategy with plasmid DNA followed by recombinant adenovirus expressing BmAMA1 as vaccines against Babesia microti infection in hamster

72%
Wang G., Yu L., Efstratiou A., Moumouni P. F. A., Liu M., Guo H., Gao Y., Cao S., Zhou M., Li J., Ringo A. E., Xuan X.
Acta Parasitologica
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2018
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tom 63
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nr 2
8

The protective effects of zinc and vitamin E supplementation against kidney toxicity by lithium in rats

72%
Hossam El-Din M.Omar H. E.-D. M., Ibrahim A. T., Magdy M. A., Ahmed E. A.
European Journal of Biological Research
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2016
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tom 06
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nr 1
9
Content available remote

The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds

72%
Olas B., Wachowicz B., Bald E., Glowacki R.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 2
Cisplatin (cis-diamminedichloroplatinum II, cisPt) is especially useful in the treatment of epithelial malignancies, however, the use of cisplatin is accompanied by several toxicities including haematological toxicity. Contrary to cisplatin, selenium-cisplatin conjugate ((NH3)2Pt(SeO3); Se-Pt) has only a slight toxicity effect on blood platelet function. In the mechanism of platinum compounds action on platelets thiols are involved. The aim of the present studies was to examine in vitro how trans-resveratrol (trans-3,4',5-trihydroxystilbene) acts on the levels of platelet glutathione (GSH) and other thiol-containing compounds and how, as an antioxidant, protecs blood platelets against the oxidative stress caused by platinum compounds (cisPt and Se-Pt). To analyse the level of thiols in human blood platelets treated with platinum compounds and with resveratrol the classical technique HPLC has been used. Blood platelets isolated by differential centrifugation of human blood were incubated (30 min, 37°C) with cisPt or Se-Pt at dose of 10 µg/ml that inhibits platelet function and with resveratrol (25 µg/ml). The obtained results indicate that platinum compounds caused in platelets a decrease of both, reduced glutathione (GSH) and free thiols of cysteine (CSH) and cysteinylglycine (CGSH). The pool of these compounds in unreduced form was increased. Platinum compounds caused the reduction of platelet protein thiols. Resveratrol (after 30 min action) at the concentration of 25 µg/ml partly reduced the platinum compounds induced decrease of platelet thiols, particularly thiols in acid-soluble fraction.
10

Evaluation of aflatoxin toxicity in Japanese quails given various doses of hydrated sodium calcium aluminosilicate

72%
Eraslan G., Liman B. C., Guclu B. K., Atasever A., Koc A. N., Beyaz L.
Bulletin of the Veterinary Institute in Puławy
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2004
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tom 48
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nr 4
11

The protective effect of quercetin-5-sulphonic acid on the membrane organotin adsorption

72%
Gabrielska J., Langner M., Przestalski S.
Cellular and Molecular Biology Letters
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1999
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tom 04
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nr 2
12

The protective effects of lidocaine on human erythrocytes stored for seven days at 04 degree Celsius

72%
Lenfant F., Lahet J. J., Chaillot B., Freysz M.
Cellular and Molecular Biology Letters
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2004
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tom 09
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nr 2
Erythrocyte storage may result in cell damage due to an alteration of membrane integrity, which results in potassium efflux and hemolysis. Lidocaine has been shown to protect erythrocytes from oxidative stress by a possible membrane effect. We conducted this study to examine the effects of lidocaine on human erythrocyte storage. Erythrocytes were kept for seven days at 04oC in the absence or in presence of plasma, and of lidocaine at 36.9 and 221.6 mM. Cell damage was assessed by measuring potassium efflux in the supernatant after seven days, and studying potassium efflux and hemolysis induced by oxidative stress. As expected, erythrocyte storage in the presence of plasma was less deleterious. Lidocaine decreased potassium efflux after 7 days' storage. Resistance toward oxidative stress was greater when the erythrocytes had been kept in the presence of plasma. Considering that lidocaine is widely used in various clinical situations, this data may be of clinical relevance.
13

Cellular response and protective effect in hens immunised with Salmonella enteritidis recombinant fimbrial SefA FimA and AgfA proteins

72%
Kuczkowski M., Wieliczko A., Kisiela D., Mazurkiewicz M., Ugorski M.
Bulletin of the Veterinary Institute in Puławy
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2004
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tom 48
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nr 4
14

Testing method for antagonistic or pathogenic potential of microbes and for potato cultivars resistance to black leg and soft rots

72%
Sharga B. M.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1999
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tom 47
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nr 2-4
15

Leptin is involved in the protective effect of lipopolysaccharide [LPS] in the caerulein-induced pancreatitis

72%
Bonior J., Jaworek J., Leja-Szpak A., Nawrot K., Kot M., Bielanski W., Sendur R., Pawlik W. W., Konturek S. J.
Journal of Physiology and Pharmacology. Supplement
|
2001
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tom 52
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nr 2
16
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Dietary intake and biochemical risk factors for cardiovascular disease in two rural regions of Crete

58%
Manios Y., Antonopoulou S., Kaliora A. C., Felliou G., Perrea D.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 1
171-181
The aim of the present study was to identify any possible protective effects of wild greens on certain biochemical cardiovascular disease (CVD) risk factors in elderly women leaving in rural Crete. For the needs of the study a region with high consumption of wild greens (Avdou) and a region with low consumption (Anogia) were identified and a representative population from each area was recruited (n= 37 and n=35 respectively). Serum lipids and fibrinogen levels, total antioxidant capacity (TAC), soluble intercellular adhesion molucule-1 (sVCAM-1), soluble vascular adhesion molucule-1 (s-ICAM-1) and haematological factors were measured in both regions during winter and summer time when wild-green plants consumption is high and low, respectively. Regarding classic lipid risk factors for arteriosclerosis no significant different between the two regions were detected. TAC was found higher in Avdou compared to Anogia during winter screening, but null in both regions during summer. Fibrinogen was found higher in Avdou compared to Anogia while no differences between the two regions were detected for sVCAM-1 and s-ICAM-1 in both screenings. The significantly higher TAC and fibrinogen values detected in Avdou could be attributed to the higher wild green consumption in that region since resent data indicated that their content in vitamin C and E as well as flavonoids is particularly high.
17

Radical scavenging capacity of cocoa polyphenols triggers anti-inflammatory properties in human monocytes and allows protective effects on H9c2 cardiomyoblast exposed to oxidative stress

58%
Arlorio M., Coisson J. D., Travaglia F., Locatelli M., Bordiga M., Zamperone A., Pietronave S., Brunelleschi S., Prat M.
Polish Journal of Food and Nutrition Sciences
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2011
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tom 61
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nr Suppl.1
18

Haematopreventive potential of sun, sulphited-dried apricot (Prunus armeniaca L.) and its kernel against ethanol toxicity in rats

58%
Yurt B., Celik I.
Polish Journal of Food and Nutrition Sciences
|
2011
|
tom 61
|
nr Suppl.1
19
Content available remote

Protective effects of vortioxetine in predator scent stress model of post-traumatic stress disorder in rats: role on neuroplasticity and apoptosis

58%
Ozbeyli D., Aykac A., Alaca N., Hazar-Yavuz A. N., Ozkan N., Sener G.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 4
20

Influence of temperature on the immune response of carp to lipopolysaccharide and whole cell Aeromonas bestiarum vaccines

58%
Guz L., Kozinska A.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 3 Suppl.
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