Wyniki wyszukiwania

1

Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor in the vasodilator effect of cyanopindolol in the human pulmonary artery

100%

Kozlowska H., Schlicker E., Kozlowski M., Baranowska M., Malinowska B.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

The aim of our study was to examine whether non ß1-/ß2-adrenoceptors participate in the relaxation of the human pulmonary artery. For this purpose the vasodilatory effect of the non-conventional partial ß-adrenoceptor agonist cyanopindolol was examined. Cyanopindolol (1 - 300 µM), studied in the presence of the ß1-/ß2-adrenoceptor antagonist propranolol, relaxed the human pulmonary artery preconstricted with serotonin 1 µM in a concentration-dependent manner (maximally by about 80%). This effect was diminished by bupranolol 10 µM (an antagonist of ß1-ß3-adrenoceptors and the low affinity state of the ß1-adrenoceptor) and CGP 20712 10 µM (known to antagonize the low-affinity state of the ß1-adrenoceptor at high concentrations). In further experiments, the effect of ß-adrenoceptor ligands on the serotonin-induced vasoconstriction was examined. The concentration-response curve for serotonin was not affected by cyanopindolol 30 µM, bupranolol 10 µM and CGP 20712 10 µM but shifted to the right by cyanopindolol 100 and 300 µM; the serotonin 5-HT2A receptor antagonist ketanserin 0.3 µM abolished the maximum contraction elicited by serotonin. In conclusion, the present study reveals that the vasodilatory effect of cyanopindolol in the human pulmonary artery consists of two components, i.e. activation of a propranolol-insensitive atypical ß-adrenoceptor and antagonism against 5-HT2A receptors.

2

Obraz krwi u indykow pozostajacych pod wplywem propranololu i ACTH

86%

Graczyk S., Zawadzki W.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Zootechnika

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2004

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tom 51

77-83

Podjęto próbę sprawdzenia czy i w jakim stopniu podawanie antagonisty receptorów beta- -adrenergicznych wpłynie na dynamikę zmian leukocytów krwi indyków traktowanych ACTH. Indyki 6-tygodniowe (Big 6), przez 72 godziny otrzymywały z wodą do picia propranolol. Ponadto, dwukrotnie, w odstępach 24-godzinnych ptaki doświadczalne otrzymały iniekcję ACTH. Dla oceny dynamiki zmian w obrazie białokrwinkowym, czterokrotnie pobrano krew (w 12, 48, 54 i 72 godzinie doświadczenia). Kontrolę stanowiła krew od indyków z fermy, utrzymywanych w podobnych warunkach. Na podstawie dokonanej oceny wskaźnika heterofile/limfocyty (H/L), potwierdzono wcześniejsze sugestie co do dużej czułości oraz przydatności obrazu krwi w ocenie oddziaływania czynników naporu środowiska. Równocześnie wykazano, że podawany indykom propranolol łagodzi zmiany wywołane podaniem ACTH. Łagodzący wpływ propranolol wydaje się dotyczyć tylko wczesnych etapów odpowiedzi ustrojowej.

3

Pharmacological specificity of beta blockers-induced inhibition of Paramecium phagocytosis

86%

Wyroba E.

Acta Protozoologica

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1989

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tom 28

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nr 2

4

Wplyw propranololu na sekrecje podstawowa trawienca u owiec

86%

Lukaszewska J., Dejneka J.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Weterynaria

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1998

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tom 58

49-53

5

Wplyw propranololu na wydzielanie trawienca u nakarmionych owiec

86%

Lukaszewska J., Dejneka J.

Medycyna Weterynaryjna

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1996

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tom 52

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nr 05

310-312

The study were performed on 4 rams with the „small abomasum” created according to Pavlov’s method. They were fed at 8 o’clock, and the experiments started at 10 o’clock i.e. at the moment of the highest abomasal juice secretion. Before examinations the animals were fitted with an epidural catheter to the external jugular vein. After collection of 3 consecutive 20 min. initial samples of abomasal juice, propranolol at a dose of 1 mg/kg was intravenously injected and the next four samples of juice were collected. In each sample the volume (ml), acid output (mmol) and pepsin output (mA) 20 min.⁻¹ were tested. It was found that in fed sheep β-adrenergic receptors have a stable inhibiting influence on abomasal juice secretion. Removal of this effect by propranolol, of β-adrenergic antagonist, increased the level of secretion of abomasal juice in sheep.

6

Wplyw domacicznego podania propranololu na motoryke macicy u krow we wczesnym okresie poporodowym

81%

Dejneka G. J., Dejneka J., Kozdrowski R., Rauluszkiewicz S., Twardon J.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2004

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tom 03

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nr 2

11-18

7

Wpływ zablokowania receptorów beta-adrenergicznych we wczesnym okresie poporodowym na przebieg inwolucji macicy u krów

72%

Rauluszkiewicz S., Dejneka J., Sabas M., Mordak R., Kubok-Gottlieb L.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Weterynaria

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1991

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tom 47

8

Wpływ PGF2-alfa na wydzielanie i skład soku trawieńcowego u owiec po zablokowaniu receptorów beta-adrenergicznych

72%

Dejneka J., Lukaszewska J., Romanski K.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Weterynaria

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1988

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tom 46

9

Central beta-adrenergic receptors are involved in the mechanism of porphyrin-induced convulsive effect in mice

72%

Maksym B., Habdas J., Plech A.

Pestycydy

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2005

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nr 4

55-63

10

Wplyw cymetydyny i propranololu na motoryke macicy u krow po ciezkim porodzie

72%

Dejneka G. J.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Weterynaria

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1995

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tom 54

13-19

11

Effect of epinephrine, propranolol, and verapamil on the chemiluminescence of neutrophils in duodenal ulcer patients

72%

Markiewicz K., Kantorski J., Malec P., Tchorzewski H.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 1-2

12

Wplyw zastosowania propranololu na przebieg okresu miedzyciazowego i plodnosc krow

72%

Mordak R.

Zeszyty Naukowe Akademii Rolniczej we Wrocławiu. Weterynaria

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1992

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tom 51

117-131

13

Beta-adrenergic antagonists influence abdominal aorta contractility by mechanisms not involving beta-adrenergic receptors

72%

Hauzer W., Bujok J., Czerski A., Rusiecka A., Pecka E., Gnus J., Zawadzki W., Witkiewicz W.

Folia Biologica

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2014

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tom 62

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nr 3

14

Wplyw propranololu i cymetydyny na motoryke macicy u krow z zatrzymaniem blon plodowych

72%

Dejneka G. J.

Medycyna Weterynaryjna

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1994

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tom 50

|

nr 11

551-553

The examinations were carried out on 6 cows with retention of fetal membranes. Uterus mobility was examined by the balloon method before and after intramuscular injection of 50 mg propranolol hydrochloride (Uterotonic-Polfa) and 1 g cimetidine (Tagamet). It was found that propranolol hydrochloride and cimetidine improved uterus mobility: the amplitude, frequency and myometric tonus increased. A spontaneous expulsion of the afterbirth within 2.5 and 5.5 hours after injection of propranolol hydrochloride and cimetidine was noted in all six examined cows.

15

Zastosowanie propranololu w terapii endometritis purulenta u krow w okresie poporodowym

72%

Ingarden J., Rauluszkiewicz S., Balcerek R., Nizanski W.

Medycyna Weterynaryjna

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1996

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tom 52

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nr 03

197-198

The investigation were carried out with 50 cows in the experimental farms of the Agricultural University in Wrocław and with 48 cows in German farms served by the Veterinary Polyclinic in Tellingstedt. Each cow with purulent endometritis was treated with an intrauterine infusion of 2% Vagothyl. Cows in experimental groups (DW and DT) were administered with 50 mg Propranolol. Before treatment, each animal was rectally investigated to find corpus luteum on the ovaries. The cows with corpus luteum were administered with PGF₂α After the treatment the vaginal discharges in experimental cows ceased after 7 days of therapy, which was shorter than in control cows (14 and more days). Involution of the uterus was terminated after 28 to 35 days in experimental groups and after 42 and more days in the control group. Administration of Propranolol during purulent endometritis treatment allowed the interpregnancy period not to be prolonged.

16

Effect of propranolol on the duration of the reversal response in Paramecium octaurelia induced by KCl and BaCl2

72%

Ucieklak A., Peche J., Lopatowska A., Wyroba E.

Acta Protozoologica

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1993

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tom 32

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nr 1

17

Propranolol modifies platelet serotonergic mechanisms in rats

72%

Zoltowski R., Pawlak R., Matys T., Pietraszek M., Buczko W.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 2

Though the mechanisms for the vascular actions of vasodilatory beta-blockers are mostly determined, some of their interactions with monoaminergic systems are not elucidated. Because there are evidences supporting a possible involvement of serotonin (5-HT) in the actions of beta-blockers, we studied the effect of propranolol on peripheral serotonergic mechanisms in normotensive and Goldblatt two-kidney - one clip (2K1C) hypertensive rats. In both groups of animals propranolol decreased systolic blood pressure, significantly increased whole blood serotonin concentration and at the same time it decreased platelet serotonin level. The uptake of the amine by platelets from hypertensive animals was lower than that of normotensive animals and it was decreased by propranolol only in the latter. In both groups propranolol inhibited potentiation of ADP - induced platelet aggregation by serotonin. In conclusion, this study provides evidence that propranolol modifies platelet serotonergic mechanisms in normotensive and renal hypertensive rats.

18

Wplyw podawania preparatu Uterotonic-Polfa na wystepowanie syndromu MMA i plodnosc macior

58%

Wawron W., Gardzinski G.

Medycyna Weterynaryjna

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1998

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tom 54

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nr 01

61-63

Tests were made to show how administration of Uterotonic-Polfa preparation, which contained 50 mg of propranolol in 10 ml of solvent, influenced occurrence of MMA syndrome and the fertility in pigs. It has been proved that application of this preparation after the birth of the first piglet limits occurrence of MMA and decreases the percentage of piglets which die shortly after birth (first 7 days). What is more, applying the preparation has beneficial influence on the fertility of sows and gilts. In percentage terms, the number of females which were rejected because of inability to become pregnant was considerably higher in control groups rather than experimental ones.

19

Amphetamine enhances natural killer cytotoxic activity via beta-adrenergic mechanism

58%

Glac W., Borman A., Badtke P., Stojek W., Orlikowska A., Tokarski J.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 11

125-132

Although addiction to amphetamine (AMPH) is a serious social and medical problem, the data concerning AMPH – immune interactions are still not numerous. To analyze the mechanism of AMPH-induced changes in the function of the immune system, rats were pretreated with ß-adrenergic receptor antagonist propranolol (PROP; 5 mg/kg, i.p.) prior to AMPH (1 mg/kg, i.p.) administration. Natural Killer cells cytotoxicity (NKCC) (51Cr-release assay), the number of LGLs (NK cells) (Timonen method), leukocytes, lymphocytes and monocytes, and plasma corticosterone level (CORT) (RIA) were evaluated in the peripheral blood and spleen. In the peripheral blood increases in NKCC (+331%), as well as in LGL (+33%) and monocyte (+65%) number observed after AMPH were partially inhibited by PROP (respectively by 30%, 19%, and 30%) in contrast to lymphopenia (-19%) and granulocytosis (+65%) which were not affected by ß-blockade. In the spleen AMPH-induced decreases in NKCC (-25%) and in all the leukocyte populations number (approximately -30%) were completely blocked by PROP. Plasma CORT level, highly elevated by AMPH (+337%), was attenuated nearly by 50% under ß-adrenergic blockade. These data indicate that AMPH-induced enhancement of cytotoxic activity of NK cell is related to ß-adrenergic mechanism.

20

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Srodki kurczace macice w leczeniu zatrzymania blon plodowych u krow i klaczy

58%

Max A.

Życie Weterynaryjne

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2006

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tom 81

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nr 09

591-594

Ograniczanie wyników

Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor in the vasodilator effect of cyanopindolol in the human pulmonary artery

Obraz krwi u indykow pozostajacych pod wplywem propranololu i ACTH

Pharmacological specificity of beta blockers-induced inhibition of Paramecium phagocytosis

Wplyw propranololu na sekrecje podstawowa trawienca u owiec

Wplyw propranololu na wydzielanie trawienca u nakarmionych owiec

Wplyw domacicznego podania propranololu na motoryke macicy u krow we wczesnym okresie poporodowym

Wpływ zablokowania receptorów beta-adrenergicznych we wczesnym okresie poporodowym na przebieg inwolucji macicy u krów

Wpływ PGF2-alfa na wydzielanie i skład soku trawieńcowego u owiec po zablokowaniu receptorów beta-adrenergicznych

Central beta-adrenergic receptors are involved in the mechanism of porphyrin-induced convulsive effect in mice

Wplyw cymetydyny i propranololu na motoryke macicy u krow po ciezkim porodzie

Effect of epinephrine, propranolol, and verapamil on the chemiluminescence of neutrophils in duodenal ulcer patients

Wplyw zastosowania propranololu na przebieg okresu miedzyciazowego i plodnosc krow

Beta-adrenergic antagonists influence abdominal aorta contractility by mechanisms not involving beta-adrenergic receptors

Wplyw propranololu i cymetydyny na motoryke macicy u krow z zatrzymaniem blon plodowych

Zastosowanie propranololu w terapii endometritis purulenta u krow w okresie poporodowym

Effect of propranolol on the duration of the reversal response in Paramecium octaurelia induced by KCl and BaCl2

Propranolol modifies platelet serotonergic mechanisms in rats

Wplyw podawania preparatu Uterotonic-Polfa na wystepowanie syndromu MMA i plodnosc macior

Amphetamine enhances natural killer cytotoxic activity via beta-adrenergic mechanism

Srodki kurczace macice w leczeniu zatrzymania blon plodowych u krow i klaczy