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1

Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX)

100%
Sarlauskas J., Nemeikaite-Ceniene A., Miseviciene L., Krikstopaitis K., Anusevicius Z., Cenas N.
Acta Biochimica Polonica
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2013
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tom 60
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nr 2
 In order to characterize the possible mechanism(s) of cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) we examined the redox properties of DNQX, and its mononitro- (NQX) and denitro- (QX) derivatives. The irreversible electrochemical reduction of the nitro groups of DNQX was characterized by the reduction peak potentials (Ep,7) of -0.43 V and -0.72 V vs. Ag/AgCl at pH 7.0, whereas NQX was reduced at Ep,7 = -0.67 V. The reactivities of DNQX and NQX towards the single-electron transferring enzymes NADPH:cytochrome P-450 reductase and NADPH:adrenodoxin reductase/adrenodoxin complex were similar to those of model nitrobenzenes with the single-electron reduction potential (E17) values of -0.29 V - -0.42 V. DNQX and NQX also acted as substrates for two-electron transferring mammalian NAD(P)H:quinone oxidoreductase (DT-diaphorase). The cytotoxicity of DNQX in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) was prevented by antioxidants and an inhibitor of NQO1, dicoumarol, and was enhanced by the prooxidant alkylating agent 1,3-bis(2-chloromethyl)-1-nitrosourea. A comparison with model nitrobenzene compounds shows that the cytotoxicity of DNQX and NQX reasonably agrees with the ease of their electrochemical reduction, and/or their reactivities towards the used enzymatic single-electron reducing systems. Thus, our data imply that the cytotoxicity of DNQX in FLK cells is exerted mainly through oxidative stress.
2
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Content available

The role of metal ions in biological oxidation - the past and the present

100%
Kleczkowski M., Garncarz M.
Polish Journal of Veterinary Sciences
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2012
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tom 15
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nr 1
Two theories, one based on the metabolism of inorganic substances, the other on metabolism of organic substances, have played an important role in the explanation of the origin of life. They demonstrate that the original environment of life on Earth was seawater containing micronutrients with structural, metabolic and catalytic activity. It is assumed that the first primitive organisms lived around 3.8 billion years ago and it was also then that the first catalytic reaction involving metal ions occurred. Biological oxidation leading to oxidative stress and cell damage in animals represents one of these types of reactions which are responsible for many animal diseases. The role of prooxidative and antioxidative actions of transition metal ions as well as their neuropathological consequences have therefore been the topic for many research projects. There is hope that metal chelates and antioxidants might prove to be a modern mode of therapy for i.e. neurogenerative diseases. The aim of this review is to show the evolution of scientific knowledge on metal ions, their biological oxidation, and an overview of their role in physiology and in pathological processes.
3

Diet and redox equilibrium of the organism

100%
Bartosz G.
Polish Journal of Food and Nutrition Sciences
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2011
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tom 61
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nr Suppl.1
4

Are antioxidants multifunctional food ingredient that can impact both health and food quality

84%
Decker E. A.
Polish Journal of Food and Nutrition Sciences
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2011
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tom 61
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nr Suppl.1
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Action mechanisms of antioxidant and prooxidants properties of flavonoids as model for understanding the oxygen metabolism

84%
Espindola C.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2013
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tom 94
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nr 2
6

Engineering stress tolerance in transgenic plants: the role of antioxidants and prooxidants

84%
Allen R. D.
Biological Bulletin of Poznań. Supplement
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1997
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tom 34
7

Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits

67%
Gumieniczek A., Hopkala H., Wojtowicz Z., Nikolajuk J.
Acta Biochimica Polonica
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2002
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tom 49
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nr 2
The present study was designed to evaluate the oxidative stress-related parameters in alloxan-induced diabetes in rabbits. After 3, 6, 12 and 24 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in heart tissue of diabetic and control groups. Superoxide dismutase and glutathione peroxidase activities and the contents of total sulfhydryl compounds significantly increased at all time inter­vals. Catalase activity increased initially (after 3 and 6 weeks), decreased after 12 weeks and increased again at the 24th week of the experiment. Glutathione reductase activity increased initially (at 3rd week), decreased below control level after 6 and 12 weeks, then increased again. Ascorbic acid concentration decreased after 3 and 6 weeks, and increased at the 12th and 24th weeks. The level of lipid peroxidation prod­ucts was reduced after 3,6 and 12 weeks of the experiment. After 24 weeks it was sig­nificantly elevated. These data suggest that hyperglycaemia induces oxidative stress in the heart but the defense mechanisms in the heart tissue are fairly efficacious against oxidative injury.
8

Relationships among indices of antioxidative activity in animals treated with selected prooxidants and antioxidants

67%
Laszczyca P.
Prace Naukowe Uniwersytetu Śląskiego w Katowicach
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1999
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tom 1842
9

Oxidation of lipids in food

67%
Wasowicz E., Gramza A., Hes M., Jelen H., Korczak J., Malecka M., Mildner-Szkudlarz S., Rudzinska M., Samotyja U., Zawirska-Wojtasiak R.
Polish Journal of Food and Nutrition Sciences
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2004
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tom 13/54
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nr Spec.Issue 1
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