The size of the optimum Xylazinum 2%-Polfa doses are determined for intramuscular and intravenous injection in horses, cows and sheep. In horses reaction of cardiovascular and respiratory system is tested after the injection of xylazine. It was found that xylazine premedication is characterized by a high degree of safety which result from a slight influence of the agent on circulatory and respiratory functions. The neuroanalgetic immobilization caused by a high dose enables diagnostic and ambulatory work less painful and it also enables preparation of animals for operation and transport. Xylasine used separately does not guarantee a full surgical tolerance. In premedication with xylasine a degree of muscle relaxation, level of sedation and analgesia in higher than with phenothiazine derivatives. Therefore, it makes more easy a local anesthesia. It also gives better conditions for recumbency of animals in inhalation anesthesia. The cooperation of xylazine with muscle relaxants (quazfenesin) and anesthetics (halothane, ketamine) allows to reduce their potent dose restraining risk of complications and to shortener period of recovery.
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