Wyniki wyszukiwania

1

Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth

100%

Dembinski A., Warzecha Z., Ceranowicz P., Pawlik M., Dembinski M., Kabat K., Konturek S. J., Kownacki P., Hladki W., Pawlik W. W.

Journal of Physiology and Pharmacology

|

2004

|

tom 55

|

nr 1,2

Previous studies have shown that pancreatic polypeptide (PP) inhibits exocrine pancreatic secretion. The aim of present study was to determine the influence of PP administration on gastric growth and blood flow. Methods: Study was performed on regularly fed, fasted or fasted and subsequently refed rats. Rats were treated with saline (intraperitoneally - i.p.), caerulein (0.24 nmol/kg/dose, i.p.), pentagastrin (0.38 µmol/kg/dose, i.p.) or PP (5 nmol/kg/dose, i.p. or 10 pmol/dose intracerebroventricularly - i.c.v.). Saline, caerulein, pentagastrin and PP were administered alone or in combination, 3 times daily during last 48 h of experiment. Results: Treatment with pentagastrin increased gastric mucosa weight, mucosal DNA synthesis and gastric blood flow in all group tested. Intraperitoneal and i.c.v administration of PP alone reduced mucosal DNA synthesis in regularly fed and refed animals, and decreased gastric blood flow in refed animals. Combination of PP i.p. or i.c.v plus pentagastrin significantly reduced the pentagastrin-evoked increase in gastric mucosa weight, gastric DNA synthesis and gastric blood flow in fasted animals, as well as regularly fed animals. In refed animals, influence of PP administration on the pentagastrin-evoked increase in gastric mucosa weight was weak and statistically insignificant, but still i.p or i.c.v administration of PP significantly reduced gastric blood flow and mucosal DNA synthesis in this group of animals. Administration of caerulein caused weak, but significant increase in gastric DNA synthesis, gastric mucosa weight and gastric blood flow in fasted rats. In regularly fed animals, caerulein significantly increased only gastric DNA synthesis and gastric blood flow. In fasted animals with subsequent refeeding, caerulein was without effect on parameters tested in the stomach. Neither i.p. nor i.c.v administration of PP affected the caerulein-evoked effects in the stomach. Conclusions: Peripheral and central administration of PP inhibits food- and pentagastrin-stimulated growth of gastric mucosa. Similar effects of low central doses of PP as the high peripheral doses of PP suggests a crucial role of the central nervous system in the inhibitory effect of PP on gastric mucosa growth.

2

Alteration of peptidergic gut-brain signaling under conditions of obesity

84%

Kuhne S. G., Stengel A.

Journal of Physiology and Pharmacology

|

2019

|

tom 70

|

nr 5

3

Identification and characterization of gastrointestinal hormone immunoreactive cells in the skin and parotoids of Chinese toad Bufo gargarizans

67%

Wang H., Wu Y.-Y., Zhang R., Zhu X., Zhang S.-Z.

Folia Histochemica et Cytobiologica

|

2014

|

tom 52

|

nr 2

4

An immunohistochemical study of the pancreatic endocrine cells of the ddN mouse

67%

Lee H. S., Chang J. H., Ku S. K.

Folia Histochemica et Cytobiologica

|

2010

|

tom 48

|

nr 3

5

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

67%

Ceranowicz P., Warzecha Z., Dembinski A.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 1

6

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Leptin, gastrointestinal and stress hormones in response to exercise in fasted or fed subjects and before or after blood donation

67%

Sliwowski Z., Lorens K., Konturek S. J., Bielanski W., Zoladz J. A.

Journal of Physiology and Pharmacology

|

2001

|

tom 52

|

nr 1

7

Brain-gut axis in pancreatic secretion and appetite control

67%

Konturek S. J., Pepera J., Zabielski K., Konturek P. C., Pawlik T., Szlachcic A., Hahn E. G.

Journal of Physiology and Pharmacology

|

2003

|

tom 54

|

nr 3

The stimulation of exocrine pancreatic secretion that has been attributed by Pavlov exclusively to various reflexes (nervism), was then found that it depend also on numerous enterohormones, especially cholecystokinin (CCK) and secretin, released by duodeno-jejunal mucosa and originally believed to act via an endocrine pathway. Recently, CCK and other enterohormones were found to stimulate the pancreas by excitation of sensory nerves and triggering vago-vagal and entero-pancreatic reflexes. Numerous neurotransmitters and neuropeptides released by enteric nervous system (ENS) of gut and pancreas have been also implicated in the regulation of exocrine pancreas. This article was designed to review the contribution of vagal nerves and entero-hormones, especially CCK and other enterohormones, involved in the control of appetitive behavior such as leptin and ghrelin and pancreatic polypeptide family (peptide YY and neuropeptide Y). Basal secretion shows periodic fluctuations with peals controlled by ENS and by motilin and Ach. Plasma ghrelin, that is considered as hunger hormone, increases under basal conditions, while plasma leptin falls to the lowest level. Postprandial pancreatic secretion, classically divided into cephalic, gastric and intestinal phases, involves predominantly CCK, which under physiological conditions acts almost entirely by activation of vago-vagal reflexes to stimulate the exocrine pancreas, being accompanied by the fall in plasma ghrelin and increase of plasma leptin, reflecting feeding behavior. We conclude that the major role in postprandial pancreatic secretion is played by vagus and gastrin in cephalic and gastric phases and by vagus in conjunction with CCK and secretin in intestinal phase. PP, PYY somatostatin, leptin and ghrelin that affect food intake appear to participate in the feedback control of postprandial pancreatic secretion via hypothalamic centers.

8

Role of selected peptides in the vagal regulation of gastric motor and endocrine pancreatic function

59%

Krowicki Z. K.

Journal of Physiology and Pharmacology

|

1996

|

tom 47

|

nr 3

9

Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori

51%

Konturek J. W.

Journal of Physiology and Pharmacology. Supplement

|

1994

|

tom 45

|

nr 1

Ograniczanie wyników

Influence of central and peripheral administration of pancreatic polypeptide on gastric mucosa growth

Alteration of peptidergic gut-brain signaling under conditions of obesity

Identification and characterization of gastrointestinal hormone immunoreactive cells in the skin and parotoids of Chinese toad Bufo gargarizans

An immunohistochemical study of the pancreatic endocrine cells of the ddN mouse

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

Leptin, gastrointestinal and stress hormones in response to exercise in fasted or fed subjects and before or after blood donation

Brain-gut axis in pancreatic secretion and appetite control

Role of selected peptides in the vagal regulation of gastric motor and endocrine pancreatic function

Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori