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Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs in both human and veterinary medicine. NSAIDs inhibit the enzyme cyclooxygenase in the arachidonic acid cascade. This mechanism results in a reduced or blocked synthesis of prostaglandins. Eicosanoids are very important for reproduction and their inhibition by NSAIDs may cause disorders in the ovarian cycle. The article summarizes the latest knowledge about the effects of NSAIDs on corpus luteum function.
The aim of the study was to determine the influence of meloxicam a nonsteroid anti-inflammatory drug, on nonspecific cellular and humoral defense mechanisms in cows. Ten heifers in two groups (experimental and control) were examined. Meloxicam was given once only to the experimental group during the course of the study. The levels of lysozyme activity and total protein as well as ceruloplasmine, gamma globulin and metabolic activity (RB A), the killing activity of macrophages (PKA) and proliferate response of lymphocyte were measured in the blood. The results indicate the immunosuppressive effect of Meloxicam on nonspecific cellular and humoral responses which, in practice, could appear as an increased sensitivity to infection, a decrease in post-vaccine immunity as well as the occurrence of various asymptomatic infections.
Cimicoxib (CX) is a new non-steroidal anti-inflammatory drug from the “coxib” family, designed for dogs. In the available literature there is little information on the pharmacokinetics of CX. The aim of this study was to evaluate the effect of food intake on the pharmacokinetic characteristics of cimicoxib. Additionally, the pharmacokinetic profile after the administration of precise doses of CX (2 mg/kg b.w.) and an approximate dose (i.e. 80 mg tablet for animals of about 40 kg) were estimated. CX concentrations were determined by a HPLC validated method. The results of pharmacokinetic analysis were similar in both studies, regardless of the dose and the degree of filling of the gastrointestinal tract (fasted, fed). In addition, we estimated the duration of the minimum effective concentration (MEC), which turned out to be similar for all the concentrations tested. The results show that neither small variations in dosage nor the presence of food in the gastrointestinal tract change the therapeutic efficacy of the analgesic in terms of its blood concentration.
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