Proteomics is a new, dynamically developing branch of science. It uses specific research tools which enable analysis of a whole protein expression in definite time and a concrete biological system. The purpose of current applications of renal and urinary proteomics are to better understand renal physiology, to explore the molecular mechanisms of the occurrence and progression of diseases, and also to identify protein biomarkers. This review is intended to discus the present status of the contribution of proteomic analysis to nephrology.
During veterinary meat inspection porcine kidneys with macroscopic lesions indicating mycotoxic porcine nephropathy were selected according to Krogh (8). About 85 (12%) of the slaughtered pigs showed macroscopic changes in kidneys indicating the disease. Ochratoxin A was found in 35 (41%) kidneys with the highest concentration 3,1 ng/g. Porcine blood samples (105) were collected at random and ochratoxin A was found in 63 (60%) samples with the highest concentration being 122 ng/ml.