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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state - case report

100%
Kuczynska M., Dziaduch E., Grzywa-Celinska A., Lachowska-Kotowska P., Mosiewicz J.
Journal of Pre-Clinical and Clinical Research
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2014
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tom 08
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nr 1
2

Effect of probiotic supplementation on liver function and lipid status in rats

84%
Skrypnik K., Bogdanski P., Loniewski I., Regula J., Suliburska J.
Acta Scientiarum Polonorum. Technologia Alimentaria
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2018
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tom 17
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nr 2
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on liver function indices of benign prostatic hyperplasia (BPH) induced rats

84%
Uroko R. I., Adamude F. A., Egba S. I., Chukwu C. N., Asadu C. L., Okwara E. C.
Herba Polonica
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2020
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tom 66
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nr 3
4

Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury

84%
Caban A., Wiaderkiewicz R., Kaminski M., Oczkowicz G., Ziaja J.
Acta Biochimica Polonica
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2000
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tom 47
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nr 4
Arterial ketone index (AKBR) which is the ratio of acetoacetic acid to 3-hydroxybutyric acid in the arterial blood, is believed to reflect the mitochondrial reduction potential of hepatocytes and general energy state of the liver. In the presented paper we challenged this hypothesis by analysing the correlation between AKBR and the results of typical liver blood tests (AspAT, AlAT, LDH, CRP) and biotransforming potential of the liver (cytochromes P450, b5 and their corresponding NADPH and NADH reductases) in the model of ischemia-reperfusion injury of rat liver. The results were compared with histochemical analysis of distribution and activity of SDH, LDH and G-6-Pase, the key marker enzymes of the liver. We have shown that, except in the case of acute phase protein (CRP), a decrease in AKBR correlated well with the increase of the level of indicator enzymes in serum. Histochemical analysis also confirmed that AKBR correlates with the degree of damage to hepatocytes during early stage of reperfusion after 60 min of liver ischemia. In the Spearman test, AKBR was significantly correlated with the changes in cytochrome P450 content and its NADPH reductase activity which indicates a high sensitivity of this test. We conclude that the decrease of AKBR value reflects the impairment of basic energy pathways and detoxicative capability of the liver.
5

The role of lysine-256 in the structure and function of sheep liver recombinant serine hydroxymethyltransferase

84%
Talwar R., Jagath J. R., Datta A., Prakash V., Savithri H. S., Rao N. A.
Acta Biochimica Polonica
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1997
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tom 44
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nr 4
The active site lysine residue, K256, involved in Schiff's base linkage with pyridoxal-5'-phosphate (PLP) in sheep liver recombinant serine hydroxymethyltransferase (rSHMT) was changed to glutamine or arginine by site-directed mutagenesis. The purified K256Q and K256R SHMTs had less than 0.1% of catalytic activity with serine and H4folate as substrates compared to rSHMT. The mutant enzymes also failed to exhibit the characteristic visible absorbance spectrum (lambda(max) 425 nm) and did not produce the quinonoid intermediate (lambda(max) 495 nm) upon the addition of glycine and H4folate. The mutant enzymes were unable to catalyze aldol cleavage of beta-phenylserine and transamination of D-alanine. These results suggested that the mutation of the lysine had resulted in the inability of the enzyme to bind to the cofactor. Therefore, the K256Q SHMT was isolated as a dimer and the K256R SHMT as a mixture of dimers and tetramers which were converted to dimers slowly. On the other hand, rSHMT was stable as a tetramer for several months, further confirming the role of PLP in maintenance of oligomeric structure. The mutant enzymes also failed to exhibit the increased thermal stability upon the addition of serine, normally observed with rSHMT. The enhanced thermal stability has been attributed to a change in conformation of the enzyme from open to closed form leading to reaction specificity. The mutant enzymes were unable to undergo this conformational change probably because of the absence of bound cofactor.
6

Natural human interferon alpha given orally has different effects on patients with distinct forms of chronic viral hepatitis B

84%
Georgiades J. A., Caban J., Zyrkowska-Bieda T., Zejc M., Jonas-Skulina U., Ciesla A.
Archivum Immunologiae et Therapiae Experimentalis
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1996
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tom 44
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nr 2-3
7
Content available remote

13C-methacetin breath test correlates with clinical indices of liver disease severity in patients with primary biliary cirrhosis

67%
Kochel-Jankowska A., Hartleb M., Jonderko K., Kaminska M., Kasicka-Jonderko A.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effect of caloric restriction on liver function in young and old ApoE/LDLr-/- mice

67%
Kostogrys R. B., Franczyk-Zarow M., Manterys A., Wybranska I.
Roczniki Państwowego Zakładu Higieny
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2018
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tom 69
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nr 1
Background. Caloric restriction (CR) leads to decrease metabolic intensity, which results in a reduction of oxygen consumption and the amount of free radicals. This can affect the function of the liver. Studies show that caloric restriction does not alter or significantly increase the enzyme activity associated with gluconeogenesis, but the effect was different according to the age of the model animals. Objective. The aim of the study was to determine the effect of caloric restriction on liver function in young and old ApoE/ LDLr-/- mice. Material and methods. Dietary experiments were performed on 2 and 5 month old male ApoE/LDLr-/- mice. Animals were divided into 3 experimental groups (n=6) and fed AIN’93G diet for 8 and 5 weeks, respectively. Control animals were fed ad libitum (AL) and housed in a colony cages. These animals were checked for dietary intake. The second group were also fed ad libitum but the animals were kept individually in cages (stress AL- sAL). Similarly to sAL group, the animals from the CR group were kept individually but received a 30% less diet compared to AL group. At the end of the experiment animals were euthanized and the blood, liver and adipose tissue have been collected. Alanine aminotransferase (ALT) as well as aspartate aminotransferase (AST) were measured in plasma. Fatty acid profile was evaluated (relative %) in adipose tissue (GC-MS). Liver’s stetosis was assessed. Results were analyzed statistically (ANOVA, STATISTICA v.10.0). Results. CR ApoE/LDLr-/- mice showed significantly lower body weight compared to animals, both AL and sAL. There were no significant differences between ALT and AST in both younger and older animals. However, negative tendencies were more pronounced in younger animals. In young animals CR significantly increased liver weight compared to AL (4.14 vs 3.73g/100g). In adipose tissue fatty acid profile differed in CR mice compared to control in young animals. Conclusions. Caloric restriction did not affect liver enzymes in mice. Caloric restriction showed similar but not identical metabolic activity in young and old mice.
9
Content available remote

Effect of subacute poisoning with bifenthrin on locomotor activity, memory retention, haematological, biochemical and histopathological parameters in mice

67%
Nieradko-Iwanicka B., Borzecki A., Jodlowska-Jedrych B.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 1
10
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Biochemical indexes of the liver functioning at the acute stage of opisthorchiasis

67%
Bakshtanovskaya I., Stepanova T., Shonin A., Ponomareva O., Terekhina V.
Wiadomości Parazytologiczne
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1998
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tom 44
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nr 3
11
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Some biochemical and nutritional studies on the effect of Panax ginseng powder extract on adult Japanese quails

51%
Osfor M. M. H.
Polish Journal of Food and Nutrition Sciences
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1995
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tom 04
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nr 2
The effect of the Panax ginseng powder extract on reproduction, growth, renal and liver functions and some blood biochemical indices of Japanese quails were investigated. Panax ginseng powder extract at 2 mg and 4 mg/bird daily increased egg number per hen, average egg weight and hatchability. It slightly improved the efficiency of feed utilization and increased the levels of serum total protein, alkaline phosphatase and aspartate amino transferase (AST). The extract decreased significantly the levels of albumin, total lipids, triacylglycerols, cholesterol and glucose, and had no effect on body weight and the levels of serum bilirubin, urea and creatinine. This suggests that long term studies should be done on many different biochemical and physiological parameters and laboratory animals.
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