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  1. 5 Acta Biochimica Polonica

  2. 4 Roczniki Państwowego Zakładu Higieny

  3. 3 Weterynaria po Dyplomie

  4. 1 Acta Scientiarum Polonorum. Zootechnica

  5. 1 Archivum Immunologiae et Therapiae Experimentalis

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  1. 3 Nowicki M.

  2. 2 Luangwilai T.

  3. 2 Ostalska-Nowicka D.

  4. 2 Robson M. G.

  5. 2 Siriwong W.

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  1. 1 2022

  2. 2 2021

  3. 1 2020

  4. 2 2019

  5. 2 2017

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1

Exclusion of four candidate kidney disease loci by linkage analysis in familial juvenile hyperuricaemic nephropathy [FJHN]

100%
Greener M., Marinaki A. M., Town M. M., Moro F., Simmonds H. A., Cameron J. S., Duley J. A., Mathew C.
Cellular and Molecular Biology Letters
|
1999
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tom 04
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nr 3
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Proteinuria - selected issues

86%
Skrzypczak W.
Acta Scientiarum Polonorum. Zootechnica
|
2021
|
tom 20
|
nr 3
3

Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease

86%
Wesoly J., Sikorski K., Lee C.-K., Bluyssen A. R.
Acta Biochimica Polonica
|
2010
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tom 57
|
nr 3
The prevalence of cardiovascular disease in patients with renal failure is extremely high and accounts for a large part of the morbidity and mortality. Inflammation participates importantly in host defense against infectious agents and injury, but also contributes to the pathophysiology of many diseases, including cardiovascular atherosclerosis, which is a main problem in patients with renal failure. Recruitment of blood leukocytes to the injured vascular endothelium characterizes the initiation and progression of atherosclerosis and involves many inflammatory mediators, modulated by cells of both innate and adaptive immunity. Excessive inflammatory and immune responses, communicated by these different cell types, are driven by inflammatory cytokines that promote associated tissue damage if cytokine signaling pathways remain unregulated. Thus, pathways capable of suppressing proinflammatory cytokine signaling hold the potential to limit life-threatening cardiovascular events caused by atherogenesis. Suppressor of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. Accumulating evidence supports the idea that dysregulation of cytokine signaling by differential SOCS expression is involved in the pathogenesis of various inflammatory, and immunological diseases, including atherosclerosis. Based on recent observations, in which SOCS expression levels are profoundly altered in kidney disease, we discuss the possibilities of SOCS as new intracellular markers of inflammation as well as their potential atherogenic properties in renal failure related cardiovascular disease.
4

Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study

86%
Renke M., Tylicki L., Rutkowski P., Knap N., Zietkiewicz M., Neuwelt A., Aleksandrowicz E., Lysiak-Szydlowska W., Wozniak M., Rutkowski B.
Acta Biochimica Polonica
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2010
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tom 57
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nr 1
119-123
 Background: Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) is a common strategy used in the management of patients with chronic kidney disease (CKD). However, there is no universal therapy that can stop progression of CKD. Pentoxifylline (PTE) is a non-specific phosphodiesterase inhibitor with anti-inflammatory properties. It has been reported to have promising effects in CKD treatment. Methods: In a placebo-controlled, randomized, cross-over study we evaluated the influence of PTE (1200 mg/day) added to RAAS blockade on proteinuria, surrogate markers of tubular injury and oxidative stress-dependent products in 22 non-diabetic patients with proteinuria (0.4-4.3 g per 24 h) with normal or declined kidney function [eGFR 37-178 mL/min]. In an eight-week run-in period, therapy using ACEI and/or ARB was adjusted to achieve a blood pressure below 130/80 mm Hg. Next, patients were randomly assigned to one of two treatment sequences: PTE/washout/placebo or placebo/washout/PTE. Clinical evaluation and laboratory tests were performed at the randomization point and after each period of the study. Results: The PTE therapy reduced proteinuria (by 26 %) as compared to placebo. There were no differences in α1-microglobulin, urine excretion of N-acetyl-β-d-glucosaminidase (NAG), hsCRP, the urinary excretion of 15-F2t-isoprostane, blood pressure (BP), eGFR and serum creatinine between the PTE and placebo groups. Conclusion: Pentoxifylline may decrease proteinuria in non-diabetic patients with CKD.
5

Targeting the chemokine network in renal inflammation

86%
Eis V., Vielhauer V., Anders H. J.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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tom 52
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nr 3
6
Content available remote

Simple obesity and renal function

72%
Sikorska D., Grzymislawska M., Roszak M., Gulbicka P., Korybalska K., Witkowski J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
7

Molecular basis of mechanisms of steroid resistance in children with nephrotic syndrome

72%
Swierczewska M., Ostalska-Nowicka D., Kempisty B., Nowicki M., Zabel M.
Acta Biochimica Polonica
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2013
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tom 60
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nr 3
 Steroid therapy, due to a wide range of anti-inflammatory properties of steroids, is a basic field of treatment in many human diseases including the nephrotic syndrome in children. However, not all patients respond positively to therapy which divides them into steroid sensitive (SS) and steroid resistance (SR) individuals. Many potential factors associated with steroid resistance have been identified so far. It seems that genetic factors associated with glucocorticoid receptor α (GRα), the structure of heterocomplex of GR as well as glycoprotein P or cytochrome P450 may play a role in the induction of glucocorticoid resistance. Here we described several of the molecular mechanisms, which can regulate glucocorticoid sensitivity and resistance. Moreover, we presented genetic defects, which can lead to various effects of treatment and, in a longer perspective, enable clinicians to individualize therapies.
8

Vitamin K status in peritoneally dialyzed patients with chronic kidney disease

72%
Stankowiak-Kulpa H., Krzyzanowska P., Koziol L., Grzymislawski M., Wanic-Kossowska M., Moczko J., Walkowiak J.
Acta Biochimica Polonica
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2011
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tom 58
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nr 4
Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p < 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.
9

Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase

72%
Zachara B. A., Gromadzinska J., Zbrog Z., Swiech R., Wasowicz W., Twardowska E., Jablonska E., Sobala W.
Acta Biochimica Polonica
|
2009
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tom 56
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nr 1
183-187
Background: Numerous authors have shown that selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity in plasma of chronic kidney disease (CKD) patients are lower than in healthy subjects, but there are only few publications on the level of GSH-Px protein in those patients and no reports on the effect of Se supplementation to HD patients on the level of this enzyme. Subjects and Methods: Se concentration and GSH-Px protein level in plasma were measured in a group of 30 CKD patients on hemodialysis (HD) supplemented with 200 μg Se/day for 3 months, and 28 patients on HD administered with placebo. Se concentration was measured by graphite furnace atomic absorption spectrometry and plasma GSH-Px protein level by the sandwich ELISA method using polyclonal antibody specific for human plasma GSH-Px. Results: Se concentration in patients on placebo did not change throughout the 3-month study period, but increased significantly in Se supplemented group. Se supplementation to CKD patients on HD had no effect on the level of GSH-Px protein. Conclusions: The lack of GSH-Px protein in CKD patients on HD is not linked to Se deficiency since the level of this element increased after Se supplementation while enzyme protein level did not change. The damaged kidney of HD patients is unable to synthesize GSH-Px, even after induction with selenium.
10

Polycystic kidney disease in white domestic pigs

72%
Paslawski R., Janiszewski A., Noszczyk-Nowak, Nowacki D., Paslawska U.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
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2013
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tom 16
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nr 2
11

Malnutrition, inflammation, atherosclerosis in hemodialysis patients

72%
Jeznach-Steinhagen A., Slotwinski R., Szczygiel B.
Roczniki Państwowego Zakładu Higieny
|
2007
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tom 58
|
nr 1
Protein-energy malnutrition with muscle wasting occurs in a large proportion of patients with chronic renal failure and is, in addition to atherosclerosis, a strong risk factor for cardiovascular mortality in dialysis patients. There is evidence that a chronic inflammation with activation of C-reactive protein and proinfalammatory cytokines is associated with increased oxidative stress and endothelial dysfunction. Strong relations between malnutrition, inflammation and atherosclerosis in dialysis patients suggest the presence of a MIA (malnutrition, inflammation and atherosclerosis) syndrome, which is associated with high mortality rate. Thus, it could be speculated that suppression of the vicious cycle of malnutrition, inflammation and atherosclerosis would improve survival in dialysis patients.
12
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effect of heat exposure on dehydration and kidney function among sea salt workers in Thailand

58%
Luangwilai T., Robson M. G., Siriwong W.
Roczniki Państwowego Zakładu Higieny
|
2021
|
tom 72
|
nr 4
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Health effects of changes in the structure of dietary macronutrients intake in Western societies

58%
Okreglicka K.
Roczniki Państwowego Zakładu Higieny
|
2015
|
tom 66
|
nr 2
A Western-type diet, characterized by a significant share of highly processed and refined foods and high content of sugars, salt, fat and protein from red meat, has been recognized as an important factor contributing to the development of metabolic disorders and the obesity epidemic around the world. Excessive body fat causes metabolic pathologies, such as insulin resistance, type 2 diabetes, dyslipidemia, cardiovascular diseases, hypertension, non-alcoholic fatty liver disease and cancer. According to the World Health Organization 1.5 billion adults are overweight, nearly 500 million are obese and 220 million suffer from type 2 diabetes. The Western-type diet is also associated with an increased incidence of chronic kidney disease. It is known that a combination of nutrients typical for this diet contributes to impaired renal function, renal steatosis and inflammation, hypertension and dysfunctional renal hormonal regulation. The Western diet is also associated with a chronic inflammatory process that is involved in all stages of atherosclerosis development and is increasingly recognized as a universal mechanism of various chronic degenerative diseases, such as autoimmune diseases, some neoplasms or osteoporosis. The present article is focused on the results of the most recent research investigating the effects of dietary macronutrients and the type of fatty acids on selected mechanisms associated with the occurrence of the most common diet-related diseases.
14

Usefulness of laparoscopy guided renal biopsy in dogs

58%
Nowicki M., Rychlik A., Nieradka R., Kander M., Depta A., Chrzastowska M.
Polish Journal of Veterinary Sciences
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2010
|
tom 13
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nr 2
15

Expression of galectin-3 in nephrotic syndrome glomerulopaties in children

58%
Ostalska-Nowicka D., Nowicki M., Kondraciuk B., Partyka M., Samulak D., Witt M.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 2
315-322
16
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Investigation of kidney function changes in sea salt workers during harvest season in Thailand

58%
Luangwilai T., Robson M. G., Siriwong W.
Roczniki Państwowego Zakładu Higieny
|
2022
|
tom 73
|
nr 1
Background. Occupational factors have previously been mentioned as contributing to decreased kidney function and the development of chronic kidney disease of unknown cause. Sea salt workers are one of the occupations facing high outdoor temperatures and a highly, intensive workload. Objective. The purpose of the study was to examine whether the kidney function of sea salt workers at the beginning of the harvest season differs from kidney function at the end of the harvest season and to identify factors that can predict the change of kidney function. Material and methods. Data were collected from salt workers (n=50) who were between 18–60 years of age without hypertension, diabetes, and kidney disease in Samut Sakhon province, Thailand. Urine specific gravity (USG) was used for hydration status and the estimated glomerular filter rate (eGFR) was used to measure kidney function. The mixed model was used to find differences over the harvest season and prediction of factors. Results. On average, the eGFR was estimated to decrease by 15.2 ml/min/1.73 m2 over the harvest season. The decline in eGFR of sea salt workers with moderate and heavy workloads were significantly faster than their light workload counterparts after controlling for other covariates. Similarly, dehydration (USG ≥ 1.030) significantly accelerated the rate of kidney function loss. Conclusions. Our study confirmed exposure to heat over the harvest season leads to decreased eGFR in sea salt workers. The rate of change of eGFR could be predicted by workload and hydration status. Workers with dehydration who performed medium to heavy workloads in farms showed faster kidney function decline than those who performed light workload.
17

Effects of dietary intervention on lipid profile and C-reactive protein in patients with chronic kidney disease

58%
Kozlowska L., Rosolowska-Huszcz D., Malecki R., Fiderkiewicz B., Rydzewski A.
Polish Journal of Food and Nutrition Sciences
|
2006
|
tom 15/56
|
nr Spec.Issue 2
High dietary glycemic index (GI) may increase colorectal cancer risk by affecting insulin and insulin-like growth factor-I levels. Colon polyps are a pre-malignant condition. We examined carbohydrate intake, the value of GI and glycemic load (GL) in patients with colon polyps recognized as adenomas (n = 83) in comparison with patients with normal result of colonoscopy (n = 73). The mean intake of carbohydrates in study group was 256.5±36.5 g/d, in control group 305.9±39.1 g/d (NS). The mean value of GI in study group was 59.8±4.1, in control group – 60.4±5.2 (NS). The value of the mean GL was 128.4±8.6 and 130.2±9.1, respectively (NS).
18
Content available remote

Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration

51%
Merline R., Lazaroski S., Babelova A., Tsalastra-Greul W., Pfeilschifter J., Schluter K. D., Gunther A., Iozzo R. V., Schaefer R. M., Schaefer L.
Journal of Physiology and Pharmacology. Supplement
|
2009
|
tom 60
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nr 4
19

Wybrane wskazniki biochemiczne w moczu w ocenie funkcji nerki pracownikow narazonych na benzyne

51%
Marchewka Z., Dlugosz A.
Bromatologia i Chemia Toksykologiczna
|
2003
|
tom 36
|
nr 2
155-159
20

Spojrzenie polskiego lekarza weterynarii

44%
Parzeniecka-Jaworska M.
Weterynaria po Dyplomie
|
2019
|
tom 20
|
nr 6
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