Wyniki wyszukiwania - AGRO

1

Caged regulators of signaling pathways

100%

Lawrence D. S., Wood J., Curley K.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

2

Protein kinase inhibitors - potential chemotherapeutic agents

100%

Shugar D.

Acta Biochimica Polonica

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1995

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tom 42

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nr 4

Protein kinase inhibitors, widely exploited for elucidation of the biological functions of kinases, have more recently come under active consideration as potential chemotherapeutic agents for tumour and other diseases. A brief overview is presented of diverse approaches to the design and development of selective protein kinase inhibitors, and related problems such as donor and acceptor specificities, stereochemical aspects, emerging relationships between protein, sugar and nucleoside kinases. In particular, and contrary to popular belief that ATP-competitive inhibifcrs cannot be selective because of the close homology of the ATP catalytic sites, numerous examples are presented of such inhibitors which are both potent and selective for a given kinase or class of kinases. Some of these are undergoing preclinical trials. Attention is also directed to the role of cellular and viral protein kinases in the ljfe cycle of viruses, and the potential of these enzymes, especially those encoded by, and essential for replication of, a given virus as targets for antiviral chemotherapy.

3

The feature of a general pharmacophore model for ATP-competing protein kinase inhibitors: the prospects for selective inhibitor design

100%

Cockcroft X., Howe T., Menear K.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

4

Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design

100%

Cole P. A.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

5

Synergistic cell growth inhibition by combination of antifolates

100%

Balinska M.

Acta Biochimica Polonica

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1993

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tom 40

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nr 3

6

Butylphenyl-dGTP as a structural probe of B family DNA polymerases

100%

Stattel J. M., Wright G. E.

Postępy Biochemii

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1995

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tom 41

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nr 5

7

Laboratoryjna ocena skuteczności działania preparatów przeciwinkrystacyjnych

89%

Gruszecka H.

Gazeta Cukrownicza

|

1988

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tom 96

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nr 04-05

8

Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation

88%

Wasik M., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 1-2

9

Adenosine-peptide conjugates as a novel class of protein kinase inhibitors

88%

Loog M., Uri A., Ek P., Jary J.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

10

1-Amino-3-phenylpropylphosphonic acid, the inhibitor of L-phenylalanine ammonia-lyase activity of higher plants

88%

Janas K. M., Olechnowicz D.

Acta Biochimica Polonica

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1994

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tom 41

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nr 2

11

ALK 5 [TGF beta RI] inhibitors: In-vitro and in-vivo characterization of novel orally active pteridines

88%

Chakravarty S., Dugar S.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

12

Selectivity of 4,5,6,7-tetrabromobenzimidazole [TBBZ] as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources

88%

Zien P., Bretner M., Zastapilo K., Szyszka R., Shugar D.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

13

Serine proteinase inhibitors from insect hemolymph

88%

Polanowski A., Wilusz T.

Acta Biochimica Polonica

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1996

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tom 43

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nr 3

Insect hemolymph, like vertebrate serum, contains several different types of polypeptides that are able to inhibit the catalytic function of proteolytic enzymes, however studies on proteins possessing this capability have been limited to a relatively few species. A comparative examination of the inhibition of trypsin, chymo- trypsin, neutrophil elastase and cathepsin G and pancreatic elastase by the hemolymph of 14 insect species belonging to six orders showed great diversity in terms of both total proteinase inhibitory capacity and specificity. Most of the inhibitors examined fall into two groups: low molecular mass proteins (below 10 kDa) related to Kunitz type inhibitors, and proteins of about 45 kDa which belong to the serpin superfamily of serine proteinase inhibitors. This minireview describes the properties, characteristics and possible biological significance of selected inhibitors.

14

Identification of highly specific cGMP-dependent protein kinase I inhibitor peptides utilizing predisposed peptide libraries

88%

Dostmann W. R. G., Nickl C., Frank R., Tegge W.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

15

Inhibitory effect of quercetin on glycolysis in blood platelets

88%

Tomasiak M.

Applied Biology Communications. Lublin Scientific Center

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1992

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tom 02

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nr 1

16

Nucleotide probes of DNA polymerases

88%

Wright G. E.

Acta Biochimica Polonica

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1996

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tom 43

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nr 1

The modified nucleotides, N2-(p-n-butylphenyl)dGTP and 2-(p-n-butylanilino) dATP and related compounds have been developed as inhibitor-probes of B family DNA polymerases. Synthetic approaches to these compounds are summarized. The nucleotides are potent, non-substrate inhibitors of DNA polymerase a. In contrast, they inhibit other members of the family with less potency but act as substrates for these enzymes. Modelling of the inhibitor: enzyme binding mechanism has been done based on the known structure of E. coli DNA polymerase I, and site-directed mutagenesis experiments to evaluate this mechanism are proposed.

17

Specific, irreversible inhibitors of the epidermal growth factor receptor [EGFR] family of tyrosine kinases

88%

Fry D. W.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

18

Structural studies on CDK2-inhibitor complexes

88%

Endicott J.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

19

Biotic series method for evaluation of soil fungi effect on plant pathogenic fungi. III. Measurement of inhibition-zone between test fungus and tested fungus in the biotic test

88%

Manka M., Manka K.

Phytopathologia Polonica

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1995

|

tom 10

20

Conformational diversity of catalytic sites of protein kinases

88%

Karlsson R. G., Sowadski J.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

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