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Preliminary study on the impact of methanolic extract of Elephantopus scaber Linn. on hair growth promoting effect in rats

100%
Sahoo H. B., Sagar R., Bhattamisra S. K., Bhaiji A.
Herba Polonica
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2013
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tom 59
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nr 2
Methanolic extract of Elephantopus scaber leaves was investigated for its role in hair growth in experimental rats. The 2% and 5% solution of prepared formulation using methanolic extract was studied for hair growth on wistar rats for 30 days. Minoxidil (2% solution) was taken as a reference standard. The prepared hair oil formulation of methanolic extract significantly (p<0.01) potentiated the hair growth initiation and completion time with dosedependent improvement in skin biopsy, hair length and hair weight. In vitro hair follicles development study showed the significant (p<0.05) improvement in the initiation of new hair follicles. Above mentioned results indicated that the methanolic extract of E. scaber rendered significant hair growth promotive effect.
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Splenic melanosis during normal murine C57BL/6 hair cycle and after chemotherapy

80%
Michalczyk-Wetula D., Salwinski A., Popik M., Jakubowska M., Plonka P. M.
Acta Biochimica Polonica
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2013
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tom 60
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nr 3
 Cancer chemotherapy is associated with serious side effects, including temporary hair loss and impairment of pigmentation. We suspect that ectopic melanin deposition occurring due to chemotherapy may add to these effects worsening the already unpleasant symptoms. We associated the ectopic occurrence of follicular melanin after chemotherapy with splenic melanosis - an interesting example of extradermal melanin localization - and we expected an increase in splenic melanin deposition after chemotherapy. Using the C57BL/6 murine model of synchronized hair cycle induced by depilation, we visualized splenic melanin by means of several histological and histochemical protocols of staining: hematoxylin and eosin, May-Grünwald-Giemsa and Fontana-Masson. Unexpectedly, the splenic deposition of melanin decreased due to application of cyclophosphamide (i.p. 120 mg/ kg body weight on day 9 post depilation). The drop was abrupt and lasted for at least 5 days (day 13-18 post depilation), as compared with normal hair cycle. Moreover, in mice with normal, depilation-induced hair cycle we observed a similar drop shortly before entering catagen (day 15 post depilation), followed by a slow and partial increase in splenic melanization up to day 27 post depilation in both groups. We conclude that cyclophosphamide negatively affects splenic melanization and/or extradermal transfer of ectopic melanin from the dystrophic hair follicles, but the most powerful down-regulator of splenic melanosis is normal and dystrophic catagen - the phase of hair follicle involution and re-modelling.
3
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The expression of the renin-angiotensin-aldosterone system in the skin and its effects on skin physiology and pathophysiology

80%
Aleksiejczuk M., Gromotowicz-Poplawska A., Marcinczyk N., Przylipiak A., Chabielska E.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 3
4

Herbs in treatment of the hairy skin of the head

80%
Linkowska M., matlawska I.
Herba Polonica
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2007
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tom 53
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nr 2
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