Wyniki wyszukiwania - AGRO

1

Genotoxicity testing using higher plants

100%

Sadowska A., Pluygers E.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

2

Studies on the mechanism of mutagenicity and genotoxicity induced by dihydralazine

100%

Chlopkiewicz B., Ejchart A., Marczewska J.

Acta Biochimica Polonica

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1995

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tom 42

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nr 3

Dihydralazine was found to be mutagenic towards S. typhimurium TA1537, TA97, TA1538 and TA98 and genotoxic towards E. coli PQ37. Using the nitro blue tetrazolium reduction method we have found that dihydralazine can generate active oxygen species. The possible role of active oxygen species in mutagenicity (Ames test) and genotoxicity (SOS Chromotest) of dihydralazine was studied by testing the influence of the different active oxygen species scavengers on these two processes. Of the active oxygen scavengers tested, only superoxide dismutase suppressed partially the mutagenic and genotoxic activity of dihydralazine. This result seems to indicate that superoxide anion play a role in these two biological events.

3

Genotoxicity of various agents evaluated by a comet assay [critical approach]

100%

Cebulska-Wasilewska A., Wiechec A., Dyga W., Panek A., Pawlyk I.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

4

Genotoxicity of lead in lupin root cells as evaluated by the comet assay

100%

Rucinska R., Sobkowiak R., Gwozdz E. A.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 3

This paper presents the results of a study on the influence of lead (Pb2+) on DNA integrity on plant cells. The study was performed on the root tips of lupin (Lupinus luteus cv. Juno) seedlings treated with two selected concentrations of Pb(NO3)2: 150 and 350 mg l-1, which were found to inhibit root growth by 50% and 70%, respectively [Ruciłska et al. Plant Physiol. Biochem. 37 (1999) 37187-37194]. Roots exposed to those external lead concentrations took up about 50 and 70 mg l-1 Pb2+ g-1 fresh weight (FW) over 48 h of incubation. A dose-dependent increase in the degree of root injury was observed in the presence of both tested concentrations. The genotoxicity of lead in lupin root cells was analysed using a mild alkaline comet assay at pH 12.3, which allows the detection of single strand breaks. The quantity of the DNA fragments migrating away from the nuclear remnant (tail area) increased proportionally to the lead content inside the roots, and was positively correlated with the degree of root injury. At 150 mg l-1 Pb2+, a high frequency distribution of nuclei having large values of tail lengths and moments was observed. By contrast, the number of nuclei with minimum values of these parameters increased at 350 mg l-1 Pb2+. This data suggests that lead at low concentrations induces the formation of short, rapidly migrating DNA fragments, whereas at higher concentrations, lead probably causes other changes to DNA that result in slower DNA migration in the electric field.

5

The inhibitory effect of ellagic acid on genotoxicity and mutagenicity induced by different doses of benzo[a]pyrene

88%

Gorski T., Gorecka D., Sikora M.

Polish Journal of Environmental Studies

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1997

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tom 06

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nr 1

Ellagic acid (EA), known as a naturally occurring plant phenol, has shown a significant influence on genotoxicity and mutagenicity induced by benzo(a)pyrene (B(a)P) in experiments with sister chromatid exchange (SCE) and Ames Salmonella typhimurium revertants. The maximum inhibitory effect of EA has been detected at low levels of B(a)P doses administered intraperitoneal to mice. The frequency of SCE per chromosome in bone marrow cells induced by B(a)P has been greatly lowered by EA at lower B(a)P doses than 0.5 mg/kg body weight of animals. The number of Ames typhimurium revertants has been reduced in the highest degree at about 10 μg of B(a)P per plate.

6

Detection of genotoxicity of atmospheric particles using a high-throughput microplate umu-test system

88%

Funasaka K., Kitano M., Nakama A., Yoshikura T., Oda Y.

Acta Biochimica Polonica

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2003

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tom 50

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nr 1

A previously developed and highly sensitive umu-microplate test system based on the nitroreductase- and O-acetyltransferase-overproducing strain Salmonella typhimurium NM3009 and the O-acetyltransferase-overproducing strain S. typhimurium NM2009 was applied to the detection of genotoxic activity in atmospheric particles in urban areas using a relatively small sample load. The results showed that the test system was able to detect slight increases in induced genotoxicity in atmospheric particles and that genotoxicity was detected mainly in the fine fraction but also partially in the coarse fraction. The present sensitive microplate test system has potential for application to the screening of various other environmental samples.

7

Root tip bioassays for genotoxicity studies of environmental liquid samples

75%

Obidoska G.

Annals of Warsaw University of Life Sciences - SGGW. Horticulture and Landscape Architecture

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2007

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tom 28

8

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Genotoxicity detection with special reference to micronucleation in the erythrocytes of fish species due to water pollution - a mini review

75%

Talapatra S. N., Nandy A.

International Letters of Natural Sciences

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2014

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tom 12

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nr 1

Water pollution is a matter of great concern in lentic and lotic ecosystems. Generally water pollutants like heavy metals, organic compounds, etc. generate from industries and domestic activities. All of these pose serious threat to the fish population in freshwater as well as marine water bodies. An impact caused by water pollutants especially genotoxins depend not only upon its concentration, but also on the duration (acute and chronic exposure) and showed individual and/or combination of pollutants or genotoxins. Genotoxicity of fish with special reference to micronucleus induction in the erythrocytes of fish is an easy screening of water pollution. The present review deals with past and present research works of major water pollutants discharge and their impact on several fish species from available literatures.

9

Dose- and time-dependent micronucleus induction in peripheral erythrocytes of catfish, Heteropneustes fossilis (Bloch) by zinc

75%

Talapatra S. N., Banerjee P., Mukhopadhyay A.

International Letters of Natural Sciences

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2014

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tom 04

As far as the detection of metal genotoxicity in fish is concerned, micronucleus (MN) test is considered an extremely suitable measure. In this study, frequencies of micronucleated erythrocytes were scored in peripheral blood of catfish, Heteropneustes fossilis (bloch) after acute in-vivo exposure of zinc at different concentrations (5, 10 and 30 ppm) in the laboratory condition. These three concentrations of zinc were tested at different durations such as 24h, 48h, 72h and 96h respectively. Highly significant (P < 0.001) increased values were obtained for MN frequencies in the peripheral erythrocytes of exposed fishes compared to control groups of fishes. These results confirm that dose- and time-dependent micronucleation in the peripheral erythrocytes of fish after short-term exposure to zinc could provide valuable information regarding zinc containing effluent quality and also help in genetic biomonitoring with this test model. In this context safe concentration of zinc vis-a-vis genotoxicity range could be evaluated for future studies.

10

Genotoxic and haematological effect of commonly used fungicide on fish Clarias batrachus

75%

Shahi J., Singh A.

Journal of Biology and Earth Sciences

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2014

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tom 04

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nr 2

11

Suitability of selected Polish field bean cultivars (Vicia faba var.minor) for the root tip genotoxicity assay (Vicia RTA)

75%

Obidoska G., Korzeniowska M., Hadam A.

Annals of Warsaw University of Life Sciences - SGGW. Horticulture and Landscape Architecture

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2017

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tom 38

12

Phytotoxicity and phytogenotoxicity of soils in the area of liquidated pesticide-burial ground

75%

Obidoska G., Karaczun Z. M., Konofalska S., Zarska B.

Annals of Warsaw University of Life Sciences - SGGW. Land Reclamation

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2018

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tom 50

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nr 3

13

Multidisciplinary study on assessment of pesticide-related genotoxic risk in floricultural workers

75%

Bolognesi C., Merlo F., Abbondandolo A.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

14

Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo

75%

Szyfter K., Szulc R., Mikstacki A., Stachecki I., Rydzanicz M., Jaloszynski P.

Journal of Applied Genetics

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2004

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tom 45

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nr 3

15

Induction of micronuclei in rat bone marrow after subchronic inhalation exposure to mixture of benzene, cyclohexanone and cyclohexane

75%

Kovalkovicova N., Sutiakova I., Legath J., Legath L., Falis M., Pistl J., Kovac G.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

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nr 3

16

Chromosome aberrations induction in freshwater mussel Dreissena polymorpha on 3-methylcholanthrene exposure

75%

Woznicki P.

Polish Journal of Environmental Studies

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2005

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tom 14

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nr 6

The influence of 3-methylcholanthrene to zebra mussel (Dreissena polymorpha) larvae was studied. The artificial spawning of zebra mussels was used for obtaining larvae. Two different concentrations of 3-methylcholanthrene were used. The chromosome analysis showed a significant increase in chromosome aberrations (CA) at the higher concentration of the compound. The resistance of zebra mussel larvae to the lower concentration of 3-methylcholanthrene indicated that zebra mussel larvae are probably not sensitive enough for the study of genotoxicity of the compounds from the PAH group.

17

Nickel impairs the repair of UV - and MNNG-damaged DNA

75%

Wozniak K., Blasiak J.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 1

Nickel(II) is reported to be genotoxic, but the mechanisms underlying its genotoxicity are largely unknown. It can interfere with DNA repair and this may contribute to its genotoxicity. We studied the effect of nickel chloride on the repair of DNA damaged by UV radiation or N-methyl-N-nitro-N-nitrosoguanidine (MNNG) in human lymphocytes using the alkaline comet assay. Nickel(II) at 1 μM caused an accumulation of DNA breaks during repair incubation, which could follow from the inhibition of the polymerization/ligation step of UV-damaged DNA repair. On the other hand, nickel(II) inhibited the formation of transient DNA breaks brought by the repair process after incubation with MNNG at 5 μM, which might follow from interference with the recognition/incision step of excision repair. Additionally, nickel at 1 μM inhibited the activity of formamidopyrimidine-DNA glycosylase (Fpg) and 3-methyladenine-DNA glycosylase II (Alk A), enzymes involved in DNA excision repair. A decrease in endonuclease III (Endo III) activity was observed at 2 and 5 μM of nickel chloride. Our results suggest that nickel(II) at non-cytotoxic concentrations can inhibit various steps of DNA excision repair, and this may contribute to its genotoxicity.

18

The genotoxicity of amsacrine in normal cells and cancer cells

75%

Blasiak J., Gloc E.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

19

Genotoxicity of pyrethroids. Part.1. Studies on mutagenic activity of pyrethroids formulations and their active ingredients in Saccharomyces cerevisiae Assay

75%

Chruscielska K., Kalhorn D., Sitowska B.

Pestycydy

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1999

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nr 4

20

Strain-dependent differences in mutagenicity and genotoxicity of cyclophosphamide in mice

75%

Ejchart A., Koziorowska J.

Acta Biochimica Polonica

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1993

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tom 40

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nr 1

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