Wyniki wyszukiwania - AGRO

1

Lipid-based antifungal agents

100%

Arikan S.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr 2

2

Myrmicinosporidium durum in Poland: a new location for this fungal ant endoparasite and updated world distribution

75%

Peral G. T., Rutkowski T., Wojtaszyn G., Espadaler X.

Acta Parasitologica

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2017

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tom 62

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nr 4

3

Compression strength along the grain of pine wood naturally affected by brown rot and reinforced with Paraloid B-72

75%

Mankowski P., Andres B., Czabanski A.

Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology

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2012

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tom 79

4

The aggregation of amphotericin B in lipid membranes - the Monte Carlo simulation

75%

Okulski W., Gawda H.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

5

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Investigations of plant infections by thermal vision and NIR imaging

75%

Hellebrand H. J., Herppich W. B., Beuche H., Dammer K. H., Linke M., Flath K.

International Agrophysics

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2006

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tom 20

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nr 1

6

The search for a genetic defect in Polish patients with chronic granulomatous disease

75%

Jurkowska M., Kurenko-Deptuch M., Bal J., Roos D.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 6

7

The influence of Fusarium species on the ultrastructure of cells of potato tuber parenchyma. II. Cell organelles

75%

Mazurkiewicz-Zapalowicz K.

Hodowla Roślin, Aklimatyzacja i Nasiennictwo

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1993

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tom 37

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nr 1-2

8

Organization of antibiotic amphotericin B in model lipid membranes. A mini review

75%

Gruszecki W. I., Gagos M., Herec M., Kernen P.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 1

Amphotericin B (AmB) is a polyene antibiotic frequently applied in the treatment of fungal infections. According to the general understanding, the mode of action of AmB is directly related to the molecular organization of the drug in the lipid environment, in particular to the formation of pore-like molecular aggregates. Electronic absorption and fluorescence techniques were applied to investigate formation of molecular aggregates of AmB in the lipid environment of liposomes and monomolecular layers formed at the argon-water interface. It appears that AmB dimers, stabilized by van der Waals interactions, are present in the membrane environment along with the aggregates formed by a greater number of molecules. Linear dichroism measurements reveal that AmB is distributed between two fractions of molecules, differently oriented with respect to the bilayer. Molecules in one fraction remain parallel to the plane of the membrane and molecules in the other one are perpendicular. Scanning Force Microscopy imaging of the surface topography of the monolayers formed with AmB in the presence of lipids reveals formation of pore-like structures characterized by the external diameter close to 17 Å and the internal diameter close to 6 Å. All the findings are discussed in terms of importance of the molecular organization of AmB in the pharmacological action, as well as of the toxic side effects of the drug.

9

Glucosamine-6-phosphate synthase, a novel target for antifungal agents. Molecular modelling studies in drug design

75%

Wojciechowski M., Milewski S., Mazerski J., Borowski E.

Acta Biochimica Polonica

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2005

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tom 52

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nr 3

Fungal infections are a growing problem in contemporary medicine, yet only a few antifungal agents are used in clinical practice. In our laboratory we proposed the enzyme L-glutamine: D-fructose-6-phosphate amidotransferase (EC 2.6.1.16) as a new target for antifungals. The structure of this enzyme consists of two domains, N-terminal and C-terminal ones, catalysing glutamine hydrolysis and sugar-phosphate isomerisation, respectively. In our laboratory a series of potent selective inhibitors of GlcN-6-P synthase have been designed and synthesised. One group of these compounds, including the most studied N3-(4-methoxyfumaroyl)-l-2,3-diaminopropanoic acid (FMDP), behave like glutamine analogs acting as active-site-directed inactivators, blocking the N-terminal, glutamine-binding domain of the enzyme. The second group of GlcN-6-P synthase inhibitors mimic the transition state of the reaction taking place in the C-terminal sugar isomerising domain. Surprisingly, in spite of the fact that glutamine is the source of nitrogen for a number of enzymes it turned out that the glutamine analogue FMDP and its derivatives are selective against GlcN-6-P synthase and they do not block other enzymes, even belonging to the same family of glutamine amidotransferases. Our molecular modelling studies of this phenomenon revealed that even within the family of related enzymes substantial differences may exist in the geometry of the active site. In the case of the glutamine amidotransferase family the glutamine binding site of GlcN-6-P synthase fits a different region of the glutamine conformational space than other amidotransferases. Detailed analysis of the interaction pattern for the best known, so far, inhibitor of the sugar isomerising domain, namely 2-amino-2-deoxy-d-glucitol-6-phosphate (ADGP), allowed us to suggest changes in the structure of the inhibitor that should improve the interaction pattern. The novel ligand was designed and synthesised. Biological experiments confirmed our predictions. The new compound named ADMP is a much better inhibitor of glucosamine-6-phosphate synthase than ADGP.

10

Dermatophyte infections in persons returning from The Tropics

75%

Jeske J., Kamerys J., Lupa S., Seneczko F., Mamos K.

Wiadomości Parazytologiczne

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1998

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tom 44

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nr 3

11

Mechanisms of Galleria mellonella cellular immune response after infection with entomopathogenic fungus Conidiobolus coronatus

63%

Ligeza-Zuber M.

Annals of Parasitology

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2012

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tom 58

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nr 4

12

Effect of econazole and benzydamine on sensory neurons in culture

63%

Mathivanan S., De la Torre Martinez R., Wolf C., Mangano G., Polenzani L., Milanese C., Ferrer-Montiel A.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

13

Scanning electron microscopy of Fusarium culmorum-infected kernels of ancient wheat species

63%

Packa D., Kulik T., Hoscik M.

Phytopathologia

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2012

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tom 63

Kernels of ancient hulled wheat species, Triticum monococcum, T. dicoccon, T. spelta, and threshable wheat species, T. polonicum, T. turanicum ('Kamut®'), were studied. Fusarium culmorum-infected kernels, classified as FDKs (Fusarium damaged kernels), were smaller, shrunken, wrinkled and lighter in colour than healthy kernels. The seed coats of the former were usually damaged, and white or pinkish-white mycelium formed on their surface. FDKs showed different fungal infection levels. Characteristic structural changes were noted in endosperm cells, including loosely arranged starch granules, a partial or even complete absence of the protein matrix enveloping starch granules, the disappearance of small starch granules and the presence of damaged large starch granules. The lowest degree of damage was observed in emmer and spelt kernels.

14

Factors leading to dermatophytosis

63%

Herizchi Qadim H., Golforoushan F., Azimi H., Goldust M.

Annals of Parasitology

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2013

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tom 59

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nr 2

Tinea or dermatophytoses are of skin superficial and fungous infections affecting keratinized tissues such as hair, nail, and superficial layer of epidermis. This study aimed at evaluating some predisposing factors for tinea corporis, because elimination or treatment of them not only ceases spreading of the lesion but also prevents reinfection. In this descriptive cross- sectional study patients who were visited in Sina Hospital in Tabriz and had confirmed tinea corporis with direct ungal smear were selected. Other regarding were age, sex, occupation and predisposing factors. Of 76 confirmed cases, 46(60.5%) were males and 30(30.5%) were females. Tinea corporis was common in the third decade. The main predisposing factor was dry skin. Diabetes was found only in 4(5.2%) patients. According to the results of the present research, xerosis was the most common factor leading to tinea corporis in these patients rather than diabetes or lymphoma that it’s diagnosis, treatment and some simple educations may inhence improvement of tinea corporis and prevents other superficial infections too.

15

Fifty Clinical Days of Medical Parasitology

63%

Wojcik A., Blaszkowska J.

Wiadomości Parazytologiczne

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2011

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tom 57

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nr 4

16

Strains differentiation of Microsporum canis by RAPD analysis using (GACA)4 and (ACA)5 primers

63%

Dobrowolska A., Debska J., Kozlowska M., Staczek P.

Polish Journal of Microbiology

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2011

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tom 60

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nr 2

Molecular analysis of dermatophytes (based on PCR fingerprinting) revealed high clonal differentiation between the genus and species. Microsporum canis (zoophilic dermatophyte, belonging to genus Microsporum), responsible for most cases of tinea capitis in children, tinea corporis in adults and dermatophytoses in cats, is very unique in comparison with other dermatophytes. Results of most molecular studies show that there is no clonal differentiation within M. canis as distinct from other species. The aim of this study was application of (GACA)4 repetitive primer and (ACA)5 primer for typing of M. canis strains isolated from human and animals in Central Poland. Fungal strains: 32 clinical isolates of M. canis, originated from patients from Central Poland; 11 strains isolated from infected cats (6) and dogs (7), reference strains of M. canis (CBS 113480), T. rubrum (CBS 120358), T. mentagrophytes (CBS 120357) and E. floccosum (CBS 970.95). The genomic DNAs of the strains were used as a template in RAPD reaction. No differentiation was observed for the analyzed M. canis strains using (GACA)4 and (ACA)5 typing.

17

Covid-19 and mucormycosis (Black Fungus): An epidemic within the pandemic

63%

Gambhir R. S., Aggarwal A., Bhardwaj A., Kaur A., Sohi R. K., Mehta S.

Roczniki Państwowego Zakładu Higieny

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2021

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tom 72

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nr 3

18

The fungi present in the sand and soil of recreational areas as possible factors of fungal infection among children: hydrolytic enzymes - a determinant of pathogenicity

63%

Kurnatowski P., Wojcik A., Blaszkowska J., Goralska K.

Annals of Parasitology

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2016

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tom 62

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nr Suppl.

19

Fungal glycoproteins and their biosynthetic pathway as potential targets for antifungal agents

63%

Tanner W., Gentzsch M., Immervoll T., Scheinost A., Strahl-Bolsinger S.

Acta Biochimica Polonica

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1995

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tom 42

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nr 4

The yeast cell wall as a good antifungal target is discussed in general. More specifically the reaction, catalyzed by Dol-P-Man: protein O-D-mannosyltransferase is proposed as a new potential target. Six genes responsible for this endoplasmic reticulum-localized reaction have been cloned and characterized so far. Triple disruptions of these genes are either lethal or the corresponding cells have to be osmotically stabilized to survive. No inhibitors of this reaction are as yet known.

20

Assembling the SARS-CoV genome - new method based on graph theoretical approach

63%

Blazewicz J., Figlerowicz M., Formanowicz P., Kasprzak M., Nowierski B., Styszynski R., Szajkowski L., Widera P., Wiktorczyk M.

Acta Biochimica Polonica

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2004

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tom 51

|

nr 4

Nowadays, scientists may learn a lot about the organisms studied just by analyzing their genetic material. This requires the development of methods of reading genomes with high accuracy. It has become clear that the knowledge of the changes occuring within a viral genome is indispensable for effective fighting of the pathogen. A good example is SARS-CoV, which was a cause of death of many people and frightened the entire world with its fast and hard to prevent propagation. Rapid development of sequencing methods, like shotgun sequencing or sequencing by hybridization (SBH), gives scientists a good tool for reading genomes. However, since sequencing methods can read fragments of up to 1000 bp only, methods for sequence assembling are required in order to read whole genomes. In this paper a new assembling method, based on graph theoretical approach, is presented. The method was tested on SARS-CoV and the results were compared to the outcome of other widely known methods.

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