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1

Growth rate of Scenedesmus acutus [Meyen] in cultures exposed to trifluralin

100%

Cetin A. K., Mert N.

Polish Journal of Environmental Studies

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2006

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tom 15

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nr 4

The objective of this study was to determine the effect of trifluralin on the growth of Scenedesmus acutus in comparison to growth without trifluralin during 5 days. For growth in trifluralin 20-40 |g/L, four days of S. acutus growth occurred compared to growth in the absence of trifluralin. This decrease in growth in S. acutus was correlated with an increased amount of trifluralin concentration. At trifluralin concentration of 60 |g/L, growth was maintaned for three days. S. acutus in the presence of at 80 |g/L trifluralin showed one-day growth. It was concluded that increasing trifluralin concentration decreased growth of S. acutus in a dose-dependent manner.

2

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Conditions of acrylamide synthesis in food and its effects on live ogranisms

86%

Biernat J., Wyka J., Figurska-Ciura D.

Polish Journal of Food and Nutrition Sciences

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2007

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tom 57

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nr 4[A]

27-30

Acrylamide is an important industrial chemical used since the 1950-ies as chemical intermediate in production of polyacrylamides. The neurotoxicity of acrylamide in humans is well-known from occupational and accidental exposures. The occurrence of acrylamide in tobacco smoke, which could be observed in smokers as an increased level of the corresponding Hb adduct. Experimental study with acrylamide in animals shown reproductive, genotoxic and carcinogenic properties. The International Agency for Research on Cancer (IARC) has classified acrylamide as a potential human carcinogen. Studies conducted in 2002 and 2003 showed that a high level of acrylamide was formed during the frying or baking of a variety of foods. Acrylamide is generated in food as a result of the Millard reaction between asparagine and carbonyl groups of reducing sugars.

3

Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons

86%

Sureshkumar S., Balachandar V., Devi S. M., Arun M., Karthickkumar A., Balamuralikrishnan B., Sankar K., Mustaqahamed S. A. K., Dharwadkar S. N., Sasikala K., Cho S.-G.

Acta Biochimica Polonica

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2013

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tom 60

|

nr 3

Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group I<35 years and group II ≥35 years). The exposed subjects were further classified into two groups based on the exposure period (<12 years and ≥12 years). The frequencies of CA and MN in exposed subjects are relatively high with respect to controls. The XRCC1 399 Arg/gln polymorphism showed a substantial smaller difference in allele frequencies between exposed and control subjects. Based on present data, it was concluded that coke oven workers under risk should be monitored for adverse effects of the any long-term exposure.

4

In vitro effects of prolonged exposure to quercetin and epigallocatechin gallate of the peripheral blood mononuclear cell membrane

86%

Margina D., Ilie M., Manda G., Neagoe I., Danciulescu-Miulescu R., Purdel C. N., Gradinaru D.

Cellular and Molecular Biology Letters

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2014

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tom 19

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nr 4

The study aimed to assess biophysical changes that take place in the peripheral blood mononuclear cell (PBMC) membranes when exposed in vitro to 10 μM quercetin or epigallocatechin gallate (EGCG) for 24 and 48 h. PBMCs isolated from hypercholesterolemia patients were compared to those from normocholesterolemia subjects. The membrane fluidity and transmembrane potential were evaluated and the results were correlated with biochemical parameters relevant to oxidative stress, assessed in the patients’ plasma. The baseline value of PBMC membrane anisotropy for the hypercholesterolemia patients was lower than that of the control group. These results correlated with the plasma levels of advanced glycation end products, which were significantly higher in the hypercholesterolemia group, and the total plasma antioxidant status, which was significantly higher in normocholesterolemia subjects. In the case of normocholesterolemia cells in vitro, polyphenols induced a decrease in membrane anisotropy (7.25–11.88% at 24 h, 1.82–2.26% at 48 h) and a hyperpolarizing effect (8.30–8.90% at 24 h and 4.58–13.00% at 48 h). The same effect was induced in hypercholesterolemia cells, but only after 48 h exposure to the polyphenols: the decrease in membrane anisotropy was 5.70% for quercetin and 2.33% for EGCG. After 48 h of in vitro incubation with the polyphenols, PBMCs isolated from hypercholesterolemia patients exhibited the effects that had been registered in cells from normocholesterolemia subjects after 24 h exposure. These results outlined the beneficial action of the studied polyphenols, quercetin and EGCG, as dietary supplements in normocholesterolemia and hypercholesterolemia patients.

5

Polycyclic aromatic hydrocarbons in the occupational environment during exposure to bitumen fumes

86%

Posniak M.

Polish Journal of Environmental Studies

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2005

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tom 14

|

nr 6

Bitumens are produced and commonly used in paving, roofing and flooring operations, as well as corrosion-protective materials in Polish industry. During these processes bitumens, heated to the temperature range from 140°C to 200°C, emit multicomponent mixtures of toxic substances into the workplace air. Assessment of workers’ exposure to polycyclic aromatic hydrocarbons (PAHs) during road paving and production of roofing papers, asphalt-rubber blend and lute was the aim of this study. The results indicated that PAHs were detected in the breathing zone of all workers. Especially dangerous to human health was the process of roofing paper production. Exposure factors for PAHs (benzo [a] pyrene, benzo [a] anthracene, anthracene, dibenzo [a, h,] antracene, benzo [b] fluoranthene, benzo [k] fluoranthene, indeno [1,2,3-c, d] pyrene, chrysene, benzo [g, h, i] perylene) went up to 20.88 μg/m3.

6

Exposure to airborne fungi during conservative dental treatment

86%

Szymanska J.

Annals of Agricultural and Environmental Medicine

|

2006

|

tom 13

|

nr 1

The aim of the study was a mycological assessment of bioaerosol forming during conservative dental treatment, taking into account concentration and type of fungal microflora, and evaluation of the influence of DUWL disinfecting protocol on the fungal contamination of the bioaerosol. The research was conducted on 25 operative sites located in public dental clinics. The air contained in the space between a patient and a dentist during conservative dental treatment with the use of a high-speed handpiece was examined. Air samples were taken using the portable RCS PLUS Air Sampler (BIOTEST AG, Dreieich, Germany) and ready-to-use agar YM Strips for yeast and mould fungi culture. The volume of the sampled air was 100 litres. Before disinfection, the concentration of fungi in the collected air samples at individual operative sites ranged from 4 × 101 cfu/m3 to 34 × 101 cfu/m3. The most common species was Penicillium herquei (62.17% of the total count), followed by other fungi: Alternaria alternata - 12.68%, Penicillium roseopurpureum - 9.41%, Rhizopus nigricans - 5.93%, Aspergillus terreus - 3.89%, Geotrichum candidum - 2.25%, Aspergillus glaucus group - 2.04%, Cladosporium cladosporoides - 1.23% and Penicillium diversum - 0.41%. The concentration of Penicillium herquei at individual operative sites ranged from 0 to 34 × 101 cfu/m3, mean 121.6 cfu/m3, Penicillium roseopurpureum - from 0 to 11 × 101 cfu/m3, mean 18.4 cfu/m3 and Alternaria alternata - from 0 to 18 × 101 cfu/m3, mean 24.8 cfu/m3. After disinfection, like before disinfection procedures, the prevailing species of fungi were: Penicillium herquei, Penicillium reseopurpureum and Alternaria alternata, which amounted to 62.6%, 18.28% and 11.36% of the isolated fungi, respectively. The recorded levels of total airborne fungi were lower after DUWL disinfection compared to those before disinfection.

7

Chromosome aberrations induction in freshwater mussel Dreissena polymorpha on 3-methylcholanthrene exposure

86%

Woznicki P.

Polish Journal of Environmental Studies

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2005

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tom 14

|

nr 6

The influence of 3-methylcholanthrene to zebra mussel (Dreissena polymorpha) larvae was studied. The artificial spawning of zebra mussels was used for obtaining larvae. Two different concentrations of 3-methylcholanthrene were used. The chromosome analysis showed a significant increase in chromosome aberrations (CA) at the higher concentration of the compound. The resistance of zebra mussel larvae to the lower concentration of 3-methylcholanthrene indicated that zebra mussel larvae are probably not sensitive enough for the study of genotoxicity of the compounds from the PAH group.

8

Tetrabromobenzene induced hepatotoxicity in rats following repeated exposure

72%

Frydrych B., Czerski J., Szymanska J. A.

Bromatologia i Chemia Toksykologiczna

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2002

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tom 35

|

nr 3

231-239

The aim of the present study was to investigate the influence of tetrabromobenzene after 28 days administration on biochemical indicators. The increase in relative liver mass as well as changes in the levels of cytochromes P-450 were observed. Porphyrins excreted in urine does not indicate strong porphyrogenic effect. No statistically significant changes were detected in other indicators of toxicity (MDA, GSH, ALT, rGT).

9

Influence of traffic on particulate-matter polycylic aromatic hydrocarbons in urban atmosphere of Zabrze, Poland

72%

Cwiklak K., Pastuszka J. S., Rogula-Kozlowska W.

Polish Journal of Environmental Studies

|

2009

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tom 18

|

nr 4

579-585

Exposure to polycyclic aromatic hydrocarbons (PAHs) of traffic-origin, adsorbed on PM10 and PM2.5 particulate matter in Zabrze, Upper Silesia, Poland, is investigated for summer 2005. Exposure levels for the particulate PAHs near the crossroads is about 66 ng/m³ and 44 ng/m³ for PM10 and PM2.5, respectively. The relative concentration increase of these compounds in road intersections compared to the concentration away from traffic emissions is equal to 189% and 237% for PAHs associated with PM10 and PM2.5, respectively. The fingerprint of PAHs contained in PM2.5 is distinctly different near the crossroads compared to the urban background site, while the fingerprints of PAHs contained in PM10 at both sites are almost the same.

10

The role of cyclooxygenase [COX]-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration

72%

Pecanha F. M., Wiggers G. A., Briones A. M., Perez-Giron J. V., Miguel M., Garcia-Redondo A. B., Vassallo D. V., Alonso M. J., Salaices M.

Journal of Physiology and Pharmacology

|

2010

|

tom 61

|

nr 1

29-36

We have previously demonstrated that chronic exposure to low-dose of mercury induced endothelial dysfunction and increased vasoconstrictor responses. The aim of this work was to investigate if mercury exposure alters contractile prostanoids production from cyclooxygenase-2 (COX-2) and its contribution to phenylephrine responses. For this, aortic segments from 3-month old Wistar rats daily treated with HgCl2 (1st dose 4.6 µg/kg, subsequent dose 0.07 µg/kg/day, i.m.) or vehicle for 30 days were used. Mercury treatment did not affect systolic blood pressure but increased phenylephrine-induced vasoconstriction. The non selective COX inhibitor, indomethacin (10 µmol/l) reduced the response to phenylephrine more in aortic segments from mercury-treated than control rats. The selective COX-2 inhibitor NS 398 (1 µmol/l), the thromboxane A2/prostaglandin H2 receptor (TP) antagonist SQ 29,548 (1 µmol/l), the TXA2 synthase inhibitor furegrelate (1 µmol/l), the EP1 receptor antagonist SC 19220 (1 µmol/l) and the AT1 receptor antagonist losartan (10 µmol/l) reduced phenylephrine response only in vessels from mercury-treated rats. TXA2 and PGE2 levels were greater in the incubation medium of vessels from treated than untreated rats; NS 398 decreased these levels only in the mercury group. COX-2 protein was localized in adventitial and endothelial cells. Aortic COX-2 mRNA expression and plasma angiotensin converting enzyme activity were greater in mercury-treated rats. These results suggest that treatment with low doses of mercury increases the release of COX-2-derived vasoconstrictor prostanoids and its participation in phenylephrine responses. The increased activation of the renin-angiotensin system after mercury treatment might be associated to this increased COX-2 activity.

11

Chronic obstructive pulmonary disease in farmers and agricultural workers - an overview

72%

Szczyrek M., Krawczyk P., Milanowski J., Jastrzebska I., Zwolak A., Daniluk J.

Annals of Agricultural and Environmental Medicine

|

2011

|

tom 18

|

nr 2

12

The presence of fungi in the interiors of libraries and the risk of exposure to mold of the Aspergillus genus - a preliminary study

72%

Gniadek A., Krzysciak P., Wrobel M.

Annals of Parasitology

|

2016

|

tom 62

|

nr Suppl.

13

Effect of prolonged and shortened photoperiods on motor activity in Syrian hamsters (Mesocricetus auratus Waterhouse) exposed to additional negative ionization of air

72%

Lenkiewicz Z., Dabrowska B., Schiffer Z.

Acta Biologica Cracoviensia. Series Zoologia

|

1989

|

tom 31

14

Endotoxin and beta-[1,3]-glucan levels in automobiles: a pilot study

72%

Wu F. F. S., Wu M.-W., Chang C.-F., Lai S.-M., Pierse N., Crane J., Siebers R.

Annals of Agricultural and Environmental Medicine

|

2010

|

tom 17

|

nr 2

327-330

15

Ochratoxin A in grain dust - estimated exposure and relations to agricultural practices in grain production

72%

Halstensen A. S., Nordby K. C., Elen O., Eduard W.

Annals of Agricultural and Environmental Medicine

|

2004

|

tom 11

|

nr 2

Ochratoxin A (OTA) is a nephrotoxin frequently contaminating grains. OTA inhalation during grain handling may therefore represent a health risk to farmers, and was the subject of this study. Airborne and settled grain dust was collected during grain work on 84 Norwegian farms. Climate and agricultural practices on each farm were registered. Penicillium spp., Aspergillus spp. and OTA in settled dust were measured. Settled dust contained median 4 µg OTA/kg dust (range 2-128), correlating with Penicillium spp. (median 40 cfu/mg; range 0-32000, rs=0.33; p<0.01). Similar levels were found across grain species, districts and agricultural practices. Penicillium levels, but not OTA levels, were higher in storage than in threshing dust (p=0.003), and increased with storage time (rs=0.51, p<0.001). Farmers were exposed to median 1 mg/m3 (range 0.2-15) dust during threshing and median 7 mg/m3 (range 1-110) dust during storage work, equalling median 3.7 pg/m3 (range 0.6-200) and median 40 pg/m3 (range 2-14000) OTA, respectively (p<0.001). Agricultural practices could not predict OTA, Penicillium or Aspergillus contamination. Compared to oral intake of OTA, the inhalant exposure during grain work was low, although varying by more than 1,000-fold. However, the farmers may occasionally be highly exposed, particularly during handling of stored grain.

16

Analysis of chosen organic tobacco smoke components and their metabolites by planar chromatography

72%

Tyrpien K.

Polish Journal of Environmental Studies

|

2006

|

tom 15

|

nr 4

Planar chromatography was used for one of the final steps of multistage analysis of chosen organic compounds (polycyclic aromatic compounds, nicotine and their derivatives) occurring in tobacco smoke as well as their transformation products. These investigations present various development and detection modes, as well as the possibility of new stationary phase O30 application. The application of planar chromatography has enabled the identification and quantification of many organic pollutants dangerous for human health and the assessment of chosen people groups exposed to tobacco smoke living in the region of Upper Silesia in Poland.

17

Determination of arsenic in biological material by hybride generation atomic absorption spectrometry method

72%

Szkoda J., Zmudzki J., Grzebalska A.

Bulletin of the Veterinary Institute in Puławy

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2006

|

tom 50

|

nr 2

18

Occupational safety and health in waste collection and recycling: the CORE research program

72%

Midtgard U., Poulsen O. M.

Annals of Agricultural and Environmental Medicine

|

1997

|

tom 04

|

nr 1

19

The role of nitric oxide in paraquat-induced oxidative stress in rat striatum

72%

Djukic M., Jovanovic M. C., Ninkovic M., Vasiljevic I., Jovanovic M.

Annals of Agricultural and Environmental Medicine

|

2007

|

tom 14

|

nr 2

The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O2 •ˉ), malondialdehyde (MDA) and nitrate (NO3ˉ), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confi rm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.

20

Dimethylbenzoic acid isomers in lung, kidney, liver and urine of rats after single and repeated inhalation exposure to pseudocumene

72%

Swiercz R., Wasowicz W., Majcherek W.

Polish Journal of Environmental Studies

|

2005

|

tom 14

|

nr 4

The objective of our study was to estimate metabolites of pseudocumene in the lung, liver, kidney and urine of rats after single and repeated inhalation exposure. Male Wistar rats were exposed to pseudocumene vapors at nominal concentrations of 25, 100 or 250 ppm in the dynamic inhalation chambers for 6 h or 4 weeks (6h/day; 5 days/week). Following exposure, three metabolites were measured in biologic material after hydrolysis: 3,4-dimethylbenzoic acid (3,4- DMBA), 2,4-dimethylbenzoic acid (2,4-DMBA) and 2,5-dimethylbenzoic acid (2,5-DMBA). The metabolites were analyzed by gas chromatography with a flame ionization detector. The study showed no significant increase in concentrations of the analyzed DMBA metabolites in the liver and lungs of rats exposed to repeated inhalation exposures to pseudocumene as compared to a single exposure. It was found that metabolic transformation of pseudocumene, leading to the production of 3,4- DMBA in the rats kidneys, are more pronounced after repeated inhalation exposure.

Ograniczanie wyników

Growth rate of Scenedesmus acutus [Meyen] in cultures exposed to trifluralin

Conditions of acrylamide synthesis in food and its effects on live ogranisms

Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons

In vitro effects of prolonged exposure to quercetin and epigallocatechin gallate of the peripheral blood mononuclear cell membrane

Polycyclic aromatic hydrocarbons in the occupational environment during exposure to bitumen fumes

Exposure to airborne fungi during conservative dental treatment

Chromosome aberrations induction in freshwater mussel Dreissena polymorpha on 3-methylcholanthrene exposure

Tetrabromobenzene induced hepatotoxicity in rats following repeated exposure

Influence of traffic on particulate-matter polycylic aromatic hydrocarbons in urban atmosphere of Zabrze, Poland

The role of cyclooxygenase [COX]-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration