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1

Some serum enzyme levels during pregnancy and postpartum in single and twin-bearing Akkaraman sheep

100%
Gurdogan F., Balikci E., Yildiz A.
Medycyna Weterynaryjna
|
2005
|
tom 61
|
nr 12
2

Activity of some antioxidative enzymes and the level of H2O2 in Viola tricolor L. plants originating from sites contaminated with heavy metals

84%
Siuta A., Kuta E., Libik-Konieczny M., Miszalski Z.
Acta Physiologiae Plantarum
|
2007
|
tom 29
|
nr 1 Suppl.
3

Performance and gastrointestinal responses of turkeys to different levels of enzyme [xylanase and glucanase] in a diet

67%
Mikulski D., Jankowski J., Zdunczyk Z., Juskiewicz J., Klebukowska L., Mikulska M.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 08
887-892
The aim of study was to evaluate the use of different levels of NSP degrading blend of enzymes (β-xylanase and β-glucanase) in practical wheat/barley-based diets for growing turkeys. The growth performance, as well as intestinal metabolism indicators of BIG-6 female turkeys was measured during the 8 weeks of experimental feeding. Turkeys were fed diets without enzyme supplementation (control group) or diets supplemented with enzyme preparation applied at doses of 50 (low), 100 (medium) and 150 mg/kg diet (high). The feed enzyme preparation contained a blend of xylanase (210 000 U/g) and β-glucanase (130 000 U/g of product). In the growth trial, enzyme supplementation did not significantly affect the body weight of the turkeys. The highest dose (150 mg/kg) of enzyme preparation decreased (p≤0.05) ileal viscosity (2.42 vs. 2.66 mPa.s), caecal viscosity (9.12 vs. 11.36 mPa.s), and weight of small intestinal tissue (10.6 vs. 13.4 g/kg BW) and feed conversion ratio of trial turkeys (by 3.5%) in comparison with the control animals. Enzyme supplementation also caused a visible growth tendency in total VFA in the caecal digesta of the turkeys. The proportions of major fatty acids also changed compared with the control group and the production of acetic acid increased, whereas the production of propionic acid decreased. No enzyme addition response was observed for lactic acid bacteria, Enterobacteriaceae, Escherichia coli or Clostridium perfringens rods in caecal digesta of turkeys, but the aerobic spore forming bacteria count decreased (p≤0.05). The best performance and physiological response of turkeys was obtained after applying the highest proportion (150 mg/kg) of enzyme preparation to the diet.
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Blood creatinine and some enzyme levels in four species of Indian carp fishes collected from a local aquatic body

67%
Kulkarni R., Pruthviraj C. B.
International Letters of Natural Sciences
|
2016
|
tom 60
5

dUTP pyrophosphatase as a potential target for chemotherapeutic drug development

67%
McIntosh E. M., Haynes R. H.
Acta Biochimica Polonica
|
1997
|
tom 44
|
nr 2
Aberrant dUTP metabolism plays a critical role in the molecular mechanism of cell killing induced by inhibitors of dihydrofolate reductase and thymidylate synthase. While considerable effort has been directed towards discovering new, more potent inhibitors of these two enzymes, little attention has been given dUTP pyrophosphatase (dUTPase)--the key modulator of cellular dUTP levels--as a potential target for chemotherapeutic drug development. Recent studies have provided evidence that dUTPase is vital for cellular and, in some cases, viral DNA replication. Furthermore, some retroviruses encode dUTPases--a fact which suggests that cellular dUTP metabolism may be more important than previously realized. Here, we briefly review current knowledge of cellular and viral dUTPases and discuss the potential of these enzymes as targets for cancer chemotherapeutic and anti-viral drug development.
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