Wyniki wyszukiwania

1

Electrophysiological properties of the liverwort Conocephalum conicum

100%

Trebacz K.

Biological Bulletin of Poznań

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2001

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tom 38

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nr 2

2

The subiculum: what it does, what it might do, and what we don't yet know

86%

O'Mara S.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 5

3

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Effects of high extracellular magnesium on electrophysiological properties of membranes of Retzius neurons in leech Haemopis sanguisuga

72%

Stanojevic M., Lopicic S., Spasic S., Vukovic I., Nedeljkov V., Prostran M.

Journal of Elementology

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2016

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tom 21

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nr 1

Magnesium is a bioessential cation with an important role in the function of excitable cells both in health and disease. Magnesium has therapeutic use as an anticonvulsant, anaesthetic, analgesic and antiarrhythmic agent. The aim of this work was to examine in detail the effects of high extracellular Mg2+ on the nerve cell membrane using classical electrophysiology techniques. The experiments were conducted on Retzius neurons in the isolated segmental ganglia of the leech Haemopis sanguisuga. Intracellular recording of membrane potential and electrical activity, as well as current clamp experiments to examine membrane input resistance and excitability, were performed prior to and during application of 20 mmol dm-3 MgCl2. The paper presents our findings on the effects of high Mg2+ on basic electrophysiological properties and activity of Retzius cells. Depolarization of the membrane potential, a decrease in the frequency of spontaneous activity, an increase in threshold potential, a decrease in cell excitability and an increase in input membrane resistance were found following an application of high Mg2+ solution. The underlying mechanisms of the overall suppressive action of Mg2+ on our cell model are discussed to be multiple Mg2+ effects on different ion channel conductances, with a possibly dominant blockade of Na+ channels and a probable modulation of activity of Ca2+-activated K+ channels by Mg2+.

4

Mechanobiology of the brain in health and disease

58%

Sheridan G. K.

Acta Neurobiologiae Experimentalis

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2019

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tom 79

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nr Suppl.1

Basic research into neurodegenerative disorders, like Alzheimer’s disease, is heavily focused on understanding genetic susceptibility and biochemical triggers of pathology, as well as disturbances to the intrinsic electrophysiological properties of affected neurons. Often overlooked is the role of mechanics, particularly mechanical properties and mechano‑sensitivity/‑responsiveness of neurons and glia. Recent evidence confirms that mechanical signals regulate CNS development and pathophysiology. In this talk, I will discuss the role of mechanics in both physiological and pathophysiological brain ageing. A defining pathophysiological hallmark of Alzheimer’s disease is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ1‑42 peptides. Amyloid plaques are hard, brittle structures scattered throughout the hippocampus and cerebral cortex and are thought to cause hyperphosphorylation of tau, neurofibrillary tangles, and progressive neurodegeneration. Glia are highly mechanosensitive cells and can sense the mismatch between the normally soft mechanical environment of the brain and very stiff amyloid plaques via mechanosensing ion channels. Both ageing and peripheral infection augment amyloid plaque‑induced upregulation of mechanoresponsive ion channels in astrocytes. Further research is required to investigate whether modulating mechanically-gated channel opening will protect or exacerbate the disease state, and most importantly, if they are novel drug targets for age‑related dementia

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

1 Biological Bulletin of Poznań

1 Journal of Elementology

1 Lopicic S.

1 Nedeljkov V.

1 O'Mara S.

1 Prostran M.

1 Sheridan G. K.

1 Spasic S.

1 Stanojevic M.

1 Trebacz K.

1 Vukovic I.

1 2019

1 2016

1 2005

1 2001

Electrophysiological properties of the liverwort Conocephalum conicum

The subiculum: what it does, what it might do, and what we don't yet know

Effects of high extracellular magnesium on electrophysiological properties of membranes of Retzius neurons in leech Haemopis sanguisuga

Mechanobiology of the brain in health and disease