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The work presents results of investigations addressing the evaluation of motor capabilities of children and adolescents with dysfunctions of the hearing organ originating from areas of eastern Poland. Results collected depict, in some part, the current health status of the examined subjects, manifested in the effectiveness of the functioning of internal systems and organs. The study was diagnostic in character, and the research method applied was a diagnostic survey. It was conducted by means of a technique of participant observation based on a questionnaire and an interview questionnaire. The level of motor capability of the subjects was evaluated based on the International Physical Fitness Test. The survey enabled evaluating the general level of motor capabilities of the pupils examined. According to guidelines of the test, three levels of motor capabilities were adopted in the study, i.e. high, medium and low. Results obtained were compared with results of the nation-wide surveys conducted for children and adolescents. The protocol of the study was approved by the Bioethics Commission for Scientific Research at the Academy of Physical Education in Katowice (Resolution No. 3/2006 of the 27th of April 2006).
Introduction. There are reports in literature which indicate the connection between impacted third molars and occurrence of symptoms of craniomandibular dysfunctions and headaches. Objectives. The aim of this study was evaluation of the outcome of patients who reported specific symptoms of craniomandibular dysfunction and had impacted mandibular third molars. Materials and method. The research material consisted of 10 women who reported to the Department of Craniomandibular Disfunctions of the Medical University in Lublin, Poland, with pain and acoustic symptoms in the Temporomandibular joint (TMJ) area. During preliminary therapy, the patients used a silicone occlusal device; ionotherapy was ordered and the patients were recommended to eliminate parafunctions. Results. Clicks before treatments were present in 6 patients, after treatment with silicone occlusal device and ionotherapy with Profenid gel in 5 patients, while two years after extraction of the impacted teeth the clicks were no longer present, and differences in the presence of clicks analyses by means of the Q-Cochran test were statistically significant between examinations 1m vs.3 (Q=10.33; p<0.01) and examinations 2 vs.3 (Q=8.40; p<0.05). Conclusions. The study showed that extraction of the mandibular third molars can cause regression of some symptoms of craniomandibular disorders.
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Homocysteine induces endothelial dysfunction via inhibition of arginine transport

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Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. High levels of plasma homocysteine (HCY) increase oxidative stress and reduce endothelial-dependent relaxation. We determined whether hyperhomocysteinemia-induced endothelial dysfunction is mediated through inhibition of cellular transport of L-arginine. In endothelial cells, HCY had a biphasic effect on arginine transport. HCY treatment for 6 hr increased L-arginine uptake by 34%; however, uptake was decreased by 25% after 24 h. HCY caused membrane hyperpolarization during both 6 and 24 h incubation periods, indicating that the negative charge facilitating arginine uptake was maintained. HCY significantly reduced expression of cellular arginine transporter protein (CAT-1) after 24 h treatment; whereas endothelial nitric oxide synthase (eNOS) protein levels and basal eNOS activity were not altered. Nevertheless, nitric oxide (NO) formation was significantly decreased. The antioxidant ascorbic acid prevented the effect of HCY on arginine transport. HCY induced formation of the peroxynitrite biomarker nitrotyrosine, which was blocked by supplemental L-arginine. HCY treatment of aortic rings caused decreased vasorelaxation to acetylcholine, which was prevented by supplemental arginine. In conclusion, HCY decreased NO formation and induced endothelial dysfunction without altering protein level or basal activity of eNOS, but through decreases in function and protein expression of the CAT-1 transporter. Reduced arginine supply may lead to eNOS uncoupling and generation of superoxide, contributing to HCY-induced oxidative stress.
Our paper proposes the evaluation of 5 select water bodies in Kraków (Bagry, Zakrzówek, Przylasek Rusiecki, and Kolna, and in the District of Krakóws water bodies formerly known as Kryspinów, currently “Zalew na Piaskach”). Their recreational values were assessed based on expert evaluation of 8 characteristics with the use of Saaty’s method to attribute weight to each characteristic. SWOT analysis was also applied, focussing on the problem of uncontrolled tourism. Kryspinow, Przylasek Rusiecki, and Kolna received the highest and very similar grades in terms of tourist attractiveness (2.475, 2.447, and 2.444, respectively), Bagry was slightly less attractive (2.224), and Zakrzówek received the worst score (0.796) due to its difficult access and lack of facilities.
Background: There are limited data about the influence of hypothyroidism and hyperthyroidism on the connective tissue component and smooth muscle cells of the thoracic aorta. The aim was to study the histological changes of the wall of the thoracic aorta in the hypothyroid and hyperthyroid rats. Morphometric measurements were also done. Materials and methods: Thirty adult rats were used. They were divided into control, hyperthyroid, and hypothyroid groups. Each group consisted of 10 rats. The animals were sacrificed at the end of 8 weeks and the descending aorta was excised. Sections were stained with haematoxylin and eosin, orcein and Masson’s trichrome stains. The morphometric measurement included: number of smooth muscle cell nuclei, number of the elastic lamellae, thickness of the tunica media, elastic fibre optic density, and relative collagen area. Results: Atheromatous plagues had been observed in the hyperthyroid group. Thinning and rupture of the elastic lamellae had been observed in the hypothyroid group; these were accompanied with intimal ulceration and aortic dissection. The average number of smooth muscle cell nuclei in the hyperthyroid group had doubled and tripled compared to their fellows in the control and hypothyroid groups, respectively. The thickness of the tunica media increased in the hyperthyroid and hypothyroid groups by 75% and 35%. In addition, the relative collagen area increased in the previously mentioned groups by 142% and 120%, respectively. On the other hand, the mean elastic fibre optic density decreased in both groups by 30%. Conclusions: Structure wall affections of the intima and media of the descending aorta were associated with the thyroid hormone dysfunctions. These changes were more severe in the hypothyroid group. (Folia Morphol 2013; 72, 4: 333–339)
Genetic manipulation conducted for many years has resulted in breeding turkeys with very intensive growth rate and high percentage of muscle tissue. These features promote dysfunctions in the cardiovascular system. The aim of this article was to present current data on the etiology of cardiovascular system diseases in turkeys. In this paper the most recent data on dilated cardiomyopathy (round heart disease), spontaneous aortic rupture and perirenal hemorrhage syndrome are described.
Echocardiography is a valuable tool for the evaluation of systolic and diastolic cardiac function. A high correlation between measurements of diastolic mitral inflow parameters analyzed with Doppler echocardiography and invasive methods makes the former valuable. The aim of this study was to ascertain if significant differences occur in diastolic myocardial parameters between dogs with no heart disease and dogs with subclinical or clinical dilated cardiomyopathy. Furthermore the aim of the study was to determine whether heart failure in dilated cardiomypathy is a result of systolic dysfunction alone or both systolic and diastolic dysfunction. Eleven parameters were analyzed: E wave, E-AT, E-DT, E time, A wave, A-AT, A-DT, A time, E+A time, E/A ratio, and IVRT. The study confirmed the value of noninvasive echocardiographic assessment of diastolic function in dogs with dilated cardiomyopathy. Significant differences were found in E wave, E-AT, E time, E/A ratio and IVRT between healthy dogs and dogs with dilated cardiomyopathy. All are characterized by a significant decrease compared to healthy dogs after taking into account age and body weight except for the E/A ratio, which significantly increased in value. There were no significant changes in any of the Doppler parameters for diastolic evaluation in subclinical cases of DCM. Advanced heart failure in dilated cardiomyopathy entails systolic and diastolic dysfunction.
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