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Background. Chronic complications of diabetes are presently the most vital problem in diabetology and the most significant challenge in the treatment of the diseases. Because of peripheral neuropathy and macroangiopathy, people with diabetes are particularly vulnerable to foot problems. The following study aims to evaluate the development of chronic complications in patients with type 2 diabetes, with a particular focus on the prevalence of limb ischemia symptoms. Material and methods. The study involved patients with type 2 diabetes mellitus and nondiabetic persons at a similar age. Diabetics were divided into 2 groups. Group 1 consisted of type 2 diabetic patients with no trophic lesions of the limbs; Group 2 included patients with diabetic foot disease; and the control group (Group 3) were the non-diabetic elderly. The study was to analyse the incidence of retinopathy, nephropathy and neuropathy in both diabetic groups. Besides, it was to evaluate changes in macroangiopathy among diabetic patients and the control group. Results. In all groups, symptoms of lower limb ischaemia were assessed, which allowed making comparisons between them. The studied material indicated that the occurrence of diabetic ulcers is mostly associated with macroangiopathy and its symptoms, polyneuropathy and particular types of neuropathy, retinopathy and horny foot skin. Conclusions. An interdisciplinary approach to the problem of the diabetic foot allows recognising its early clinical symptoms.
Pancreatic cancer is one of the most severe malignant disease, with an extreme degree of lethality, considering that the survival rate at 5 years is up to 4%. In addition, a major disadvantage of this disease is the fact that the diagnosis is determined very late in the evolution of the disorder, despite the development of new technologies. In this way, the main symptoms are occurring later on, when the tumour is well to advanced and totally unresectable. Up to now surgery is the only modality that can provide a greater chance of survival, but unfortunately the pancreatic resection has many unknowns and controversies around it. Moreover, the studies on endocrine pancreatic function after resection are very few and somehow controversial. In this way, in the present minireview we will describe the most relevant experimental data regarding the post-resection pancreatogenic diabetes, the pancreatic polypeptide PP and the pancreatic glucose metabolism after resection or the glucose metabolism after partial or total pancreatectomy.
Human serum contains several glycosaminoglycans (GAGs), mainly chondroitin sulphates and significantly less of heparan sulphate + heparin and dermatan sulphate. The non-insulin-dependent diabetes mellitus (with vascular complications) was associated with a significant increase in total serum GAG concentration, mainly of chondroitin sulphates and dermatan sulphate, with a simultaneous decrease in heparan sulphate + heparin level. These alterations were much more evident in patients with poor metabolic control. Hyaluronic acid (undetectable in healthy subjects and in patients with good metabolic control) appeared only in trace amounts in poorly controlled diabetic individuals. The obtained data allow to conclude that the diabetes mellitus-associated disturbances in tissue GAG metabolism lead to significant alterations in serum GAG composition.
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