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1

The IP vs. VDE competition as a key factor determining the stability of the MgBX5 (X = F, CL) compounds

100%
Sikorska C., Skurski P., Jaworski S.
Current Topics in Biophysics. Supplement
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2011
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tom 34
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nr A: Posters
2

An influence of compounds acting on glutamatergic and noradrenergic receptors on the tremor induced by harmaline; automatic measurements by force plate actimeters

100%
Glowacka U., Wardas J., Kuter K., Berghauzen K., Pilc A., Ossowska K., Acher F.
Acta Neurobiologiae Experimentalis
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2013
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tom 73
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nr 1
Harmaline, a derivative of beta-carboline is a well-known tremorgenic compound which induces the action and postural tremor in animals. Oscillation frequency of this symptom is equal to 10–12 Hz in rats. A synchronous activation of the olivo-cerebellar pathway and release of glutamate in the cerebellum has been suggested to be a primary cause of the harmaline-induced tremor. Subtype 4 of metabotropic glutamate receptors (mGluR4) is mainly an autoreceptor and its stimulation decreases glutamate release. MGluR4 receptors are abundant in the cerebellum and therefore their influence on the harmaline-induced tremor might be expected. However, mechanisms underlying this symptom are more complex and seem to involve also other neurotransmitter systems, especially the noradrenergic neurotransmission in the cerebellum. The aim of the present study was to examine an influence of an orthosteric agonist of mGluR4 – AF22898:8 on the tremor induced by harmaline in rats. An antagonist of beta-adrenoceptors – propranolol was used as a reference compound. Tremor of animals was measured automatically by actimeters where four force tranducers measured the force exerted by an animal on the floor. The Power Spectra analysis which uses a Fourier transform generated power spectra for examination of the tremor. The average power over three specific frequency bands AP1 (0–8 Hz), AP2 (9–15 Hz), AP3 (16–25 Hz), and tremor indices, which quantified the differences in power between the AP2 and AP1 (T1) and AP3 and AP1 (T2) were used to quantify the tremor intensity. Harmaline in doses of 7.5–25 mg/kg i.p. induced the generalized tremor which was dose-dependent and lasted longer than 2 h. Propranolol in a dose of 20 mg/kg i.p. diminished the tremor (decreased T1 and AP2) induced by harmaline (15 mg/ kg i.p.). In contrast, AF22898:8 administered in doses of 2.5–20 mg/kg i.p. was ineffective. The present results indicate that the harmaline-induced tremor measured in the force plate actimeters consititute a good model for screening antitremorgenic compounds. However, in contrast to earlier expectations the agonist of mGluR4 had no influence on this symptom.The study was supported by the grant of the National Science Centre nr N N401 570638, and partly by Statutory Funds of the Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland.
3

Fluorescence of Maillard reaction compounds and FAST index in breads

84%
Przygodzka M., Zielinski H., Piskula M. K.
Polish Journal of Food and Nutrition Sciences
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2011
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tom 61
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nr Suppl.1
4
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Influence of some compounds on development of Sphaerotheca pannosa var. rosae

84%
Wojdyla A. T.
Journal of Plant Protection Research
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2000
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tom 40
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nr 2
Influence of triforine (standard), garlic juice, Antifung 20 SL (20% vermicompost), Atpolan 80 EC (76% mineral oil), Biosept (grapefruit juice) and Atonik AL on development of Sphaerotheca pannosa var. rosae was evaluated. Garlic juice, Atpolan 80 EC and Biosept applied as rose spray gave similar effect in the control S. pannosa var. rosae as triforine. Observations under scanning electron microscop indicated that 24 hrs after rose spraying all tested compounds cause almost complete collapse of conidia and hyphe.
5

Targeting malaria with specific CDK inhibitors

84%
Geyer J. A., Kathcart A. K., Bhattacharjee A. K., Chen Y., Cortes E. A., Prigge S. T., Waters N. C.
Cellular and Molecular Biology Letters
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2005
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tom 10
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nr Suppl.2
6

Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance

67%
Michalak K., Hendrich A. B., Wesolowska O., Pola A., Lania-Pietrzak B., Motohashi N., Shirataki Y., Molnar J.
Cellular and Molecular Biology Letters
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2002
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tom 07
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nr 2
7

Evaluation of the SOS chromotest for detection of genotoxic drugs

59%
Marczewska J., Chlopkiewicz B., Ejchart A., Koziorowska J.
Acta Microbiologica Polonica
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1993
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tom 42
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nr 2
8

The effects of different compounds in some essential oils on in vitro gas production

51%
Kilic U., Boga M., Gorgulu M., Sahan Z.
Journal of Animal and Feed Sciences
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2011
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tom 20
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nr 4
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