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Longterm decrease in the CD57 lymphocyte subset in a patient with chronic Lyme disease

100%

Stricker R. B., Burrascano J. J., Winger E. E.

Annals of Agricultural and Environmental Medicine

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2002

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tom 09

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nr 1

2

Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis

86%

Maretskyi V., Lobanets N.

Health Problems of Civilization

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2015

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tom 09

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nr 2

The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patients and thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.

3

The risk of overweight and obesity in chronic diseases among Warsaw inhabitants measured by self-reported method

86%

Supranowicz P., Wysocki M. J., Car J., Debska A., Gebska-Kuczerowska A., Gromulska L.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

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nr 3

Background. Obesity is well known cause of various diseases. However, there are only a few studies which enable to compare directly the magnitude of risk in different groups of chronic diseases. Objectives. The aim of presented paper was to identify a magnitude of the risk of chronic diseases attributable to overweight and obesity on the basis of data on weight and height self-reported by respondents. Material and methods. The survey was conducted among 402 Warsaw inhabitants selected by non-random method. Overweight and obesity was measured by Body Mass Index (BMI) on the basis of the data of weight and height reported by respondents. According to WHO criteria the normal weight is defined as BMI 18.5 - 24.9 kg/m2, overweight as BMI 25.0 - 29.9 kg/m2, and obesity as BMI 30 kg/m2 or more. The following groups of chronic diseases were included: cancer, diabetes and other endocrine diseases, mental disorders, cardiovascular diseases, respiratory diseases, digestive diseases, arthritis and allergy disorder. Results. Obesity measured by self-reported method was recognised as significant risk factor for diabetes (OR=9.6, Cl: 2.0152.8), respiratory diseases (OR=10.6, Cl: 3,0-333,7), cardiovascular diseases (OR=5.2, Cl: 1.9-108.3), arthritis (OR=6.3, Cl: 2.4-266.7), digestive diseases (OR=3,8, Cl: 1.3-83.6) and mental disorders (OR=5.8, Cl: 1.5-29.1), while overweight significantly increased the risk of diabetes (OR=4.4, Cl: 1.2-10.8), respiratory diseases (OR=3.2, Cl: 1.4-22.2), cardiovas- culardiseases (OR=2.9, Cl: 1.2-6.4) andarthritis (OR=3.0, Cl: 1.1-9.6) Conclusions. Our findings showed that data on weight and height collected by survey method provide some information about the magnitude of the risk regarding particular groups of diseases attributable to overweight and obesity, nevertheless, underestimation ofBMI calculated in this way should be taken into account.

4

Prevalence of tuberculosis in cattle in Turkey

86%

Gumussoy K. S., Atasever A., Aydin F., Ozcan M., Beyaz L., Hizlisoy H., Abay S.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 03

305-308

The aim of the study was to determine the prevalence of bovine tuberculosis in the Kayseri province in Turkey and to compare histopathology and direct microscope examinations, culture and BACTEC radiometric methods. The lungs and bronchial and mediastinal lymph nodes, collected from 3216 cattle slaughtered at 5 slaughterhouses belonging to both the public and private sector, were examined from September 2003 to August 2004. In macroscopic examinations lesions were noted in 248 (7.7%) of the cattle. In histopathology examinations caseous tuberculosis was observed in 57% of the lungs, in 57% of the bronchial and in 53% of the mediastinal lymph nodes. In direct microscopy, acid-fast bacilli were seen in 33% of the lungs, in 33% of the bronchial and in 28% of the mediastinal lymph nodes. In culture, Mycobacterium bovis was isolated in 19% of the lungs, 19% of the bronchial and in 17% of the mediastinal lymph nodes. In the BACTEC method, Mycobacterium spp. was isolated in 21% of the lungs, in 21% of the bronchial and in 17% of the mediastinal lymph nodes. In conclusion, the prevalence of bovine tuberculosis in slaughtered cattle in Kayseri province is 1.49%, and the BACTEC radiometric method is a rapid and sensitive method for diagnosing M. bovis.

5

The progress in bariatric surgery

86%

Pardela M., Wiewiora M., Sitkiewicz T., Wylezol M.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 6

35-44

Morbid obesity, caused by fat tissue accumulation, is a serious multi-factorial chronic disease, with rapidly increasing prevalence in most countries in the world including Poland. Conservative treatment of morbid obesity is almost always unsatisfactory and that is why several surgical methods have been developed. There are four kinds of methods: malabsorptive procedures; restrictive procedures; malabsorptive/restrictive procedures and experimental procedures. The development of bariatric surgery goes back to 1952 and since that time it has been evolving dynamically. All the surgical methods have benefits and disadvantages. Presently the introduction of minimally invasive surgical techniques seems to be very safe, efficient and cost-effective in treatment for morbid obesity. New methods are also being evaluated, such as gastric myo-electrical stimulation. Bariatric surgery will still be developing until we understand all the factors responsible for it is origin.

6

Impaired histamine binding by gastric juice of patients with duodenal ulcer

86%

Zak-Nejmark T., Malolepszy J., Liebhart J., Kuczynska-Sekieta K., Liebhart E., Nadobna G.

Archivum Immunologiae et Therapiae Experimentalis

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1989

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tom 37

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nr 1-2

7

Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study

86%

Renke M., Tylicki L., Rutkowski P., Knap N., Zietkiewicz M., Neuwelt A., Aleksandrowicz E., Lysiak-Szydlowska W., Wozniak M., Rutkowski B.

Acta Biochimica Polonica

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2010

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tom 57

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nr 1

119-123

Background: Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) is a common strategy used in the management of patients with chronic kidney disease (CKD). However, there is no universal therapy that can stop progression of CKD. Pentoxifylline (PTE) is a non-specific phosphodiesterase inhibitor with anti-inflammatory properties. It has been reported to have promising effects in CKD treatment. Methods: In a placebo-controlled, randomized, cross-over study we evaluated the influence of PTE (1200 mg/day) added to RAAS blockade on proteinuria, surrogate markers of tubular injury and oxidative stress-dependent products in 22 non-diabetic patients with proteinuria (0.4-4.3 g per 24 h) with normal or declined kidney function [eGFR 37-178 mL/min]. In an eight-week run-in period, therapy using ACEI and/or ARB was adjusted to achieve a blood pressure below 130/80 mm Hg. Next, patients were randomly assigned to one of two treatment sequences: PTE/washout/placebo or placebo/washout/PTE. Clinical evaluation and laboratory tests were performed at the randomization point and after each period of the study. Results: The PTE therapy reduced proteinuria (by 26 %) as compared to placebo. There were no differences in α1-microglobulin, urine excretion of N-acetyl-β-d-glucosaminidase (NAG), hsCRP, the urinary excretion of 15-F2t-isoprostane, blood pressure (BP), eGFR and serum creatinine between the PTE and placebo groups. Conclusion: Pentoxifylline may decrease proteinuria in non-diabetic patients with CKD.

8

Candida dubliniensis Sullivan et al., a new species in the human respiratory system

86%

Biedunkiewicz-Ziomek A., Dynowska M.

Acta Mycologica

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2004

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tom 39

|

nr 1

9

Physical maps of the chromosomes of Haemophilus influenzae Sb

86%

Kauc L., Michalowska A., Gnas-Wiernicka M.

Acta Microbiologica Polonica

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1996

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tom 45

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nr 1

10

High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice

72%

Zielinska M., Szymaszkiewicz A., Salaga M., Zatorski H., Wlodarczyk J., Jacenik D., Kordek R., Krajewska W. M., Misicka A., Fichna J., Sacharczuk M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

11

Contact allergy to nickel: Patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes

72%

Czarnobilska E., Jenner B., Kaszuba-Zwoinska J., Kapusta M., Obtulowicz K., Thor P., Spiewak R.

Annals of Agricultural and Environmental Medicine

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2009

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tom 16

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nr 1

37-41

12

Tissue expression of S100 proteins in gallbladder mucosa of the patients with calculous cholecystitis

72%

Szmyt M., Kasprzak A., Malkowski W., Surdyk-Zasada J., Przybyszewska W., Siodla E., Seraszek-Jaros A., Jagielska J.

Folia Histochemica et Cytobiologica

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2013

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tom 51

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nr 2

13

Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats

72%

Kato S., Ohkawa F., Ito Y., Amagase K., Takeuchi K.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 4

147-155

The role of nitric oxide synthase (NOS) isozymes in the aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats was investigated. Two weeks after injection of Freund’s complete adjuvant, the animals were given indomethacin, and the stomach was examined for damage 4 h later. Indomethacin caused hemorrhagic lesions in the normal rat stomach, and these lesions were markedly aggravated in arthritic rats. Pretreatment with L-NAME (a nonselective inhibitor of NOS) and aminoguanidine (a relative selective inhibitor of iNOS) did not affect the ulcerogenic response in normal rats but dose-dependently prevented the aggravation of lesions in arthritic rats, but the effect of aminoguanidine was apparently less than that of L-NAME. The increased ulcerogenic response in arthritic rats was significantly suppressed by 1400 W (a selective inhibitor of iNOS) and L-NIO (a selective inhibitor of eNOS) but not by L-NPA (a selective inhibitor of nNOS). The concurrent administration of 1400 W and L-NIO almost totally abolished the aggravation of damage in arthritic rats. The expressions of eNOS and iNOS but not nNOS in the gastric mucosa were clearly enhanced in arthritic rats. Mucosal levels of non-protein sulfhydryls were significantly lower in arthritic rats than those in normal rats. The aggravation of damage in arthritic rats was significantly prevented by glutathione. These results suggest that the increased ulcerogenic response to indomethacin in arthritic rat stomachs is mediated by NO derived from eNOS in addition to iNOS. It is assumed that eNOS/NO may act harmfully on the gastric mucosa of arthritic rats with mucosal SH deficiency.

14

Lead and cadmium content in human hair in Central Pomerania [Northern Poland]

72%

Trojanowski P., Trojanowski J., Antonowicz J., Bokiniec M.

Journal of Elementology

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2010

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tom 15

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nr 2

363-384

Samples of hair collected in 2004-2007 from 416 persons living in Central Pomerania were analyzed. The subjects donating hair represented a vast spectrum of age, from a tenmonth- old child to a 75-year-old person. The subjects were selected randomly. Lead and cadmium were determined by atomic absorption spectrophotometry using an ASA-3 spectrometer. The average content of the metals in the hair samples was 3.20 μg g–1 (Pb) and 0.284 μg g–1 (Cd). The highest concentration of lead in human hair (about 3.88 μg g–1) was determined for the age group 61-75 years, and that of cadmium (0.406 μg g–1) – for the age group 26-50 years. The lowest concentrations of these metals in human hair (2.07 and 0.152 μg g–1, respectively) were determined for the age group of 0-15 years. Most hair samples (50%) contained 2.01-4.00 μg g–1 Pb, while 45% of the samples contained 0.001- -0.300 μg g–1 of cadmium. Studying the dependence of the content of lead and cadmium in hair on the gender of subjects, it was discovered that in all age groups males had more lead and cadmium (3.79 and 0.334 μg g–1, respectively) than females (2.63 μg g–1 and 0.236 μg g–1). This study has also demonstrated that the environment affects the content of the analyzed metals in hair. The average value of lead and cadmium concentrations for people living in the country were 2.39 μg g–1 for Pb and 0.214 μg g–1 for Cd, while for the people living in towns and cities, the respective values were 4.17 and 0.361 μg g–1. The present study has demonstrated how nutrition affects lead and cadmium content in human hair. Among the subjects, 17% had been on some kind of a diet, predominatly easily digestible and light foods. The lowest content of these metals (on average, 2.08 μg g–1 Pb and 0.141 μg g–1 Cd) was found in hair of people on a diet, while the hiest levels (3.54 μg g–1 Pb and 0.315 μg g–1 Cd) were determined in people who did not limit consumption of meat and dairy products. Among the analyzed population, 241 persons suffered from chronic disease. The average content of lead and cadmium in hair of healthy subjects was 3.05 μg g–1 Pb and 0.257 μg g–1 Cd, but in patients suffering from arthrosclerosis, allergy and hyperplasia prostate the levels of lead and cadmium in hair reached the upper values of the se limits. Hair of the patients who suffered from cardiovascular disease showed deificiency of these metals (on average, 1.73 μg g–1 Pb and 0.182 μg g–1 Cd).

15

Anti-inflammatory effects of flavonoids evaluated in murine models: a descriptive review

72%

Carmona-Hernandez J. C., Angel-Isaza J., Gonzalez-Correa C. H., Narvaez-Solarte W.

Animal Science Papers and Reports

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2017

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tom 35

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nr 4

Several chronic diseases are directly related to inflammatory states and lead to tissue damage and failure. Millions of people die worldwide from inflammation-associated pathologies such as cardiovascular diseases, diabetes and obesity. Inadequate dietary habits contribute to a deterioration of these diseases. Diet anti-inflammatory models should be studied in more detail. Fruit and vegetable polyphenols have shown anti-inflammatory benefits. This article is aimed at evaluating the inflammatory response in different murine models administered polyphenol rich diets, with a primary focus on flavonoids extracted from plants and evaluated in several inflammatory induced conditions. Carrageenan as an inflammatory agent was used to induce inflammation and several anti-inflammatory polyphenols were monitored.

16

Evaluation of the correlations between magnesium concentration and selected serum lipid components in women and men of different age with chronic kidney failure

72%

Orowicz W., Wyrembska A.

Journal of Elementology

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2010

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tom 15

|

nr 2

321-329

In literature of the recent years, more and more attention has been paid to the correlations between magnesium and blood lipids. Lipid balance disorders induced by hypomagnesaemia bring about changes in the liquidity of cellular membranes. Increased migration of lipids, in particular of VLDL and LDL, across arterial walls has been observed in hypomagnesaemia, with their consequential deposition in the internal membrane. Kidneys, apart from urine production and elimination, fulfil many other important functions in organism. They determine normal functioning of the whole organism, while disorders in their function lead to serious changes in homeostasis. Lipid balance disorders are a serious risk factor in the development of atherosclerotic lesions in patients with chronic kidney failure. The aim of this study was to examine the correlations between magnesium concentration and total cholesterol and HDL- and LDL-cholesterol contents in women and men with chronic kidney failure under and over 50 years of age. Subjects were divided into four groups: K1 – 14 women 34-50 years old, K2 – 14 women over 50 years old, M1 – 17 men 30-50 years old, and M2 – 13 men over 50 years old. Tests were made using a COBAS INTEGRA analyser. High concentration of Mg, exceeding the upper limit of reference values, was observed both in two women and men groups (K1 – 1.26 mmol(+) kg–1; K2 – 1.25 mmol(+) kg–1; M1 – 1.13 mmol(+) kg–1; M2 – 1.16 mmol(+) kg–1). Also the levels of total and HDL-cholesterol in all subjects were within physiological limits (respectively: K1 – 4.61 and 1.23 mmol(+) kg–1; K2 – 4.69 and 1.29 mmol(+) kg–1; M1 –3.94 and 1.20 mmol(+) kg–1; M2 – 3.98 and 1.16 mmol(+) kg–1). Only the LDL-cholesterol concentration in the group of younger men was below normal limit (1.93 mmol(+) kg–1). Small positive correlations were obtained between Mg content and that of total and LDL-cholesterol in older women and younger men groups as well as between Mg and HDL-cholesterol contents in both men groups. At the same time, a small negative correlation was obtained between Mg and LDL-cholesterol concentrations in the older men group. These correlations were statistically non-significant.

17

Histopathological examination of selected internal organs of Pastel minks in relation to oxidative state parameters

72%

Bis-Wencel H., Lopuszynski W., Saba L., Bryl M., Rowicka A.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 4

The aim of the study was histopathological characteristics of mink females showing a tendency to decrease body condition in a perinatal period against a background of selected parameters of antioxidant state. The minks were divided into two groups according to body condition scoring system (BCS). The blood was collected twice: after weaning and at the end of the production cycle. The serum activity of oxidative state enzymes was determined. Anatomic and histopathological examinations were conducted after the production cycle. Samples of the liver, kidneys, small intestine, and ovaries were fixed in 10% buffered formalin and stained with haematoxylin-eosin and Sudan IV. The histopathological examinations revealed hyperaemia of the liver and kidneys, with large content of blood in the capillary and central vessels of obese females. The kidney structure was normal in animals of experimental group. On the other hand, kidneys of control group animals showed degenerative changes in the epithelial cells of the tubules of the excretory part, especially of the proximal tubules. Against the background of the obtained results, it should be stated that lower activities of selected enzymes with anatomical and histopathological changes were obtained in the animals with worse body condition.

18

Buxtonellosis and coccidiosis of cattles in Northern Serbia

72%

Kocis J., Ilic T., Becskei Z., Radisavljevic K., Dimitrijevic S.

Acta Parasitologica

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2015

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tom 60

|

nr 1

19

Intraepidermal nerve fiber density in vulvar lichen sclerosus and normal vulvar tissues

72%

Milian-Ciesielska K., Chmura L., Dyduch G., Jagers C., Radwanska E., Adamek D.

Journal of Physiology and Pharmacology

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2017

|

tom 68

|

nr 3

20

In vitro generation of pancreatic beta-cells for diabetes treatment. I. Beta-like cells derived from human pluripotent stem cells

72%

Cierpka-Kmiec K., Wronska A., Kmiec Z.

Folia Histochemica et Cytobiologica

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2019

|

tom 57

|

nr 1

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