Wyniki wyszukiwania

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Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor in the vasodilator effect of cyanopindolol in the human pulmonary artery

100%

Kozlowska H., Schlicker E., Kozlowski M., Baranowska M., Malinowska B.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 3

The aim of our study was to examine whether non ß1-/ß2-adrenoceptors participate in the relaxation of the human pulmonary artery. For this purpose the vasodilatory effect of the non-conventional partial ß-adrenoceptor agonist cyanopindolol was examined. Cyanopindolol (1 - 300 µM), studied in the presence of the ß1-/ß2-adrenoceptor antagonist propranolol, relaxed the human pulmonary artery preconstricted with serotonin 1 µM in a concentration-dependent manner (maximally by about 80%). This effect was diminished by bupranolol 10 µM (an antagonist of ß1-ß3-adrenoceptors and the low affinity state of the ß1-adrenoceptor) and CGP 20712 10 µM (known to antagonize the low-affinity state of the ß1-adrenoceptor at high concentrations). In further experiments, the effect of ß-adrenoceptor ligands on the serotonin-induced vasoconstriction was examined. The concentration-response curve for serotonin was not affected by cyanopindolol 30 µM, bupranolol 10 µM and CGP 20712 10 µM but shifted to the right by cyanopindolol 100 and 300 µM; the serotonin 5-HT2A receptor antagonist ketanserin 0.3 µM abolished the maximum contraction elicited by serotonin. In conclusion, the present study reveals that the vasodilatory effect of cyanopindolol in the human pulmonary artery consists of two components, i.e. activation of a propranolol-insensitive atypical ß-adrenoceptor and antagonism against 5-HT2A receptors.

2

Pharmacological specificity of beta blockers-induced inhibition of Paramecium phagocytosis

86%

Wyroba E.

Acta Protozoologica

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1989

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tom 28

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nr 2

3

NO-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT 1A-receptors

86%

Chlopicki S., Kozlovski V. I., Gryglewski R. J.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,1

Nebivolol is a unique ß1-adrenoceptor antagonist which possesses peripheral vasodilator properties dependent on endothelial NO. Nebivolol-induced release of NO was attributed to its L stereoisomer and to its ability to stimulate endothelial ß2, ß3 adrenoceptors or 5-HT1A receptors. Here, in the isolated guinea pig heart we analysed coronary vasodilator potency of L- and D-nebivolol and a possible role of ß2, ß3 adrenoceptors and 5-HT1A receptors in nebivolol-induced vasodilation. Surprisingly, we found that not only L-nebivolol (3-30x10-6 M) but also D-nebivolol (3-30x10-6 M) induced coronary vasodilation, and both responses were inhibited by L-NAME (10-4 M). In contrast with the stereoisomers of nebivolol, atenolol at the equimolar concentrations did induce slight vasoconstriction. The nonselective ß1/ß2- adrenoceptor antagonist - nadolol (10-5 M), the selective ß3-adrenoceptor antagonist - L 748337 (10-6 M) and the 5 HT1A receptor antagonist - NAN 190 (5 x 10-6 M), none of them inhibited coronary vasodilation induced by D- and L-nebivolol. In summary, in the isolated guinea pig heart both D- and L-nebivolol act as coronary vasodilators. Coronary vasodilation induced by stereoisomers of nebivolol is mediated by endothelium-derived NO and does not depend on ß2, ß3 adrenoceptors or 5 HT1A receptors.

4

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Pharmacology of histamine liberation. Cationic amphiphilic drugs and mast cells

86%

Nosal R.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 3

5

Cyclic nucleotide-dependent relaxation in human umbilical vessels

72%

Provitera L., Cavallaro G., Griggio A., Raffaeli G., Amodeo I., Gulden S., Lattuada D., Ercoli G., Lonati C., Tomaselli A., Mosca F., Villamor E.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 4

6

The effects of adjuvant arthritis on the myometrial adrenergic functions in the nonpregnant and the late-pregnant rat

72%

Csik G., Spiegl G., Minorics R., Falkay G., Zupko I.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 5

7

Blocade of the beta-adrenoceptors with carazolol improves fertility of artificial insemination in Awassi sheep

72%

Bademkiran S., Celik R., Gurbulak K., Yokus B., Ozdemir N.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 03

298-300

This investigation aimed to study the effect on fertility parameters of one or two artificial inseminations (AI) and the administration (carazalol) before insemination of β-adrenoceptor blocker in Awassi sheep. A total of 144 Awassi sheep with their oestrous synchronized were divided into 4 groups. Group A1 had a single artificial insemination applied at 52 hours after (the sponge was removed), group A2 had a single artifical insemination applied while for preinsemination 0.01 mg/kg carazalol were given i.v. Group B1 had artificial insemination appled twice at 52 and 60 hours. B2 group had artificial insemination appled twice at 52 and 60 hours and for preinsemination 0.01 mg/kg carazalol were given i.v. As a results, the ratios of not observed oestrus after 25 days were 55.6%, 61.1%, 63.9% and 69.4% in groups A1, A2, B1 and B2 respectively. The ratios of pregnancy were diagnosed ultrasonographically after the 30th day of artificial insemination as 47.2%, 50.0%, 52.8% and 61.1% in groups A1, A2, B1 and B2 respectively. The ratios of birth by means of artificial insemination were 41.7%, 47.2%, 47.2% and 55% in groups A1, A2, B1 and B2 respectively. The degree of fertility was found to be higher in the group in which the sheep applied artificial insemination twice with 8 hours intervals and administrated β-adrenoceptor blocker preinsemination. However, the difference between groups was not significant (p>0.05).

8

Vasopressin release in response to hypovolaemia in the conscious rat and the effect of opioid and aminergic receptor antagonists

72%

Peysner K., Forsling M. L.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

Conscious rats were given i. p. polyethylene glycol (PEG) or dextran injections to compare their efficacy in inducing moderate hypovolaemia. Dextran was found unsuitable, producing large variability in the the plasma vasopressin (A VP) concentrations. Putative neurotransmitters involved in the A VP response to hypovolaemia and in basal release were examined using opioid, and ß-adrenoceptor and dopamine receptor-blocking agents. A dose of PEG was chosen to produce a decrease in blood volume of approx 14.5% giving plasma AVP concentrations of 19.0±4.6 pmol/1. Naloxone and phenoxy- benzamine failed to influence AVP release under both hypovolaemic and basal conditions. Prazosin also failed to influence the AVP response. In contrast propranolol elevated the plasma AVP concentrations in both conditions. Haloperidol enhanced basal AVP release but did not influence release during hypovolaemia. Guanethidine pretreatment partially blocked the response to hypovolaemia, but did not affect basal plasma AVP. Thus it appears that aminergic pathways have an inhibitory influence on AVP release under hypovolaemic and basal conditions. However, endogenous opioids do not appear to contribute significantly to the hypovolaemic response.

9

Effect of propranolol on the duration of the reversal response in Paramecium octaurelia induced by KCl and BaCl2

72%

Ucieklak A., Peche J., Lopatowska A., Wyroba E.

Acta Protozoologica

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1993

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tom 32

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nr 1

10

Melatonin-induced protein synthesis in the rat parotid gland

58%

Cevik-Aras H., Godoy T., Ekstrom J.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 1

Melatonin occurs in large amounts in the intestinal mucosa and is released during a meal. Recent studies of ours reveal that exogenous melatonin evokes the in vivo secretion of protein and amylase from the rat parotid gland. The aim of the present study was to investigate the effect of melatonin on the protein synthesis of the parotid gland of pentobarbitone-anaesthetised rats as estimated by the rate of incorporation of [3H]leucine into trichloroacetic acid-insoluble material of the gland. Compared with the parotid protein synthesis (set at 100%) of those rats exposed to an intravenous infusion of melatonin (25 mg/kg during 1 hour), under muscarinic and - and ß-adrenoceptor blockade, the synthesis in the corresponding glands of saline-treated control rats was less (by 25%). The synthesis was also less when the melatonin administration was combined with the melatonin 2-preferring receptor antagonist luzindole (24%), the non-selective nitric oxide synthase inhibitor L-NAME (18%) and the neuronal nitric oxide synthase inhibitor N-PLA (21%). Almost all the melatonin receptor-mediated effect was due to nitric oxide generation via the activity of neuronal type nitric oxide synthase. The present findings lend further weight to the idea that salivary glandular activity associated with food intake is hormonally influenced and they also suggest clinical implications for melatonin in the treatment of xerostomia. Since melatonin is known to exert anti-inflammatory actions in the oral cavity, the stimulatory effect of melatonin may include the synthesis of proteins of importance for the oral defence.

Ograniczanie wyników

Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor in the vasodilator effect of cyanopindolol in the human pulmonary artery

Pharmacological specificity of beta blockers-induced inhibition of Paramecium phagocytosis

NO-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT 1A-receptors

Pharmacology of histamine liberation. Cationic amphiphilic drugs and mast cells

Cyclic nucleotide-dependent relaxation in human umbilical vessels

The effects of adjuvant arthritis on the myometrial adrenergic functions in the nonpregnant and the late-pregnant rat

Blocade of the beta-adrenoceptors with carazolol improves fertility of artificial insemination in Awassi sheep

Vasopressin release in response to hypovolaemia in the conscious rat and the effect of opioid and aminergic receptor antagonists

Effect of propranolol on the duration of the reversal response in Paramecium octaurelia induced by KCl and BaCl2

Melatonin-induced protein synthesis in the rat parotid gland