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  1. 3 Acta Biochimica Polonica

  2. 2 Progress in Plant Protection

  3. 2 Top Agrar Polska

  4. 2 Życie Weterynaryjne

  5. 1 Acta Agrobotanica

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  1. 3 Piszczek J.

  2. 2 Bielenin A.

  3. 2 Czopowicz M.

  4. 2 Janczak C.

  5. 2 Kaba J.

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  1. 2 2022

  2. 1 2020

  3. 1 2018

  4. 2 2015

  5. 1 2013

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1

Antimicrobial activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles

100%
Wolinowska R., Zajdel-Dabrowska J., Starosciak B. J., Kazimierczuk Z.
Acta Microbiologica Polonica
|
2002
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tom 51
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nr 3
2

Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives

100%
Kazimierczuk Z., Upcroft J. A., Upcroft P., Gorska A., Starosciak B., Laudy A.
Acta Biochimica Polonica
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2002
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tom 49
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nr 1
Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-sub- stituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remark­able activity against nosocomial strains of Stenotrophomonas malthophilia, and an ac­tivity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity.
3

Antiproliferative activity of new benzimidazole derivatives

86%
Blaszczak-Swiatkiewicz K., Olszewska P., Mikiciuk-Olasik E.
Acta Biochimica Polonica
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2013
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tom 60
|
nr 3
A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) showed a very good antiproliferative effect and three of them were specific for hypoxia conditions (8, 14, 11). Compound 8 was the most cytotoxic against human lung adenocarcinoma A549 cells at hypoxic conditions. Hypoxia/ normoxia cytotoxic coefficient of compound 14 (4.75) is close to hypoxia/normoxia cytotoxic coefficient of tirapazamine (5.59) - a reference compound in our experiments and this parameter locates it between mitomycin C and 2-nitroimidazole (misonidazole). Screening test of caspase-dependent apoptosis proved that exposure to A549 cells of compounds 7-8 and 13-14 for 48 h promote apoptotic cell death. These results supplement our earlier study of the activity of new potentialy cytotoxic heterocyclic compounds against selected tumor cells.
4

Benzimidazoles influence on uncoupling of host muscle mitochondria in Trichinella spiralis and T.pseudospiralis infections

86%
Boczon K., Wandurska-Nowak E., Karczewska M.
Acta Parasitologica
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1993
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tom 38
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nr 3
In muscle mitochondria of mice infected by Trichinella spiralis larvae and treated by following benzimidazoles: mebendazole (MBZ), oxfendazole (OXF) and thiabendazole (TBZ) their differential influence on uncoupling of host mitochondria was observed. Both MBZ and OXF (in doses of 80 mg/kg of body weight and 60 mg/kg of body weight, respectively) improved the bioenergetic properties of host muscles mitochondria i.e. increase the respiratory control index (RCI) in the muscular phase of this infection. The experiments with the use of OXF in Trichinella pseudospiralis infection have proved that this drug normalizes also in this infection the activity of two mitochondrial inner membrane-located enzymes: mtATPase and SDH in the muscular phase of the infection. A similar effectiveness of OXF in the latter infection was reached using a single and a double dose of the drug (200 mg/kg of body weight, divided into two parts).
5
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Reactions of winter wheat to Mycosphaerella graminicola [anamorph Septoria tritici]

86%
Vechet L., Sychrova E.
Acta Agrobotanica
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2005
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tom 58
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nr 1
Reaction of six winter wheat culti vars and lines (Vlasta, Šárka, Charger, 00ST022, SG-U8044C a SG-U2113B) to Mycosphaerella graminicola isolate BR-331 and UH-05 on leaf segments of the detached second seedling leaf of cultivars placed on water agar with bezimidazole in clear plastic box were tested. The isolate BR-331 produced high occurrence of the disease in the cultivar Šárka, middle occurrence (the percentage covered by lesions bearing pycnidia) in the cultivar Vlasta and SG-U8044C and low occurrence in the line 00ST0022. The isolate UH-105 produced high occurrence in the cultivar 00ST022 and middle occurrence in the cultivar Vlasta. The cultivar Charger was resistant. The cultivar Šárka was attacked at least. Results show on different virulence of M. graminicola isolates to wheat cultivars.
6

Study on benzimidazole anthelminthic residues in ruminant liver and kidneys by HPLC

86%
Unvermis E., Colak H., Tumer I., Ergun O.
Medycyna Weterynaryjna
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2005
|
tom 61
|
nr 04
7

Jak dzialaja fungicydy?

72%
Janczak C.
Top Agrar Polska
|
2004
|
nr 04
130
8

Anthelmintic residues in goat and sheep dairy products

72%
Jedziniak P., Olejnik M., Rola J. G., Szprengier-Juszkiewicz T.
Bulletin of the Veterinary Institute in Puławy
|
2015
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tom 59
|
nr 4
A multiresidue method (LC-MS/MS) for determination of wide range of anthelmintics was developed. The method covered benzimidazoles: albendazole (and metabolites), cambendazole, fenbendazol (and metabolites), flubendazole (and metabolites), mebendazole (and metabolites), oxibendazole, thiabendazole (and metabolites), triclabendazole (and metabolites); macrocyclic lactones: abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin; salicylanilides: closantel, ioxynil, nitroxynil, oxyclosamide, niclosamide, rafoxanid and others: clorsulon, derquantel, imidocarb, monepantel (and metabolites), morantel, praziquantel, and pyrantel. The method was used to examine the potential presence of anthelmintics in goat and sheep milk and dairy products from the Polish market. A total of 120 samples of milk, yoghurt, cottage cheese, cream cheese, and curd were analysed. None of the samples were found positive above CCa (1-10 µg/kg) except for one cottage cheese in which traces of albendazole sulfone were detected (5.2 µg/kg) and confirmed. The results of the study showed negligible anthelmintic residues in the goat and sheep milk and dairy products and confirm their good quality.
9

Podstawowe wiadomosci o lekach weterynaryjnych. Cz.6. Srodki przeciwpasozytnicze

72%
Winnicki S., Piontek D.
Chów Bydła
|
1996
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tom 39
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nr 06
19
10

Effectiveness of Befran 25 SL in the control of bull's eye rot on apples and perennial canker on apple trees

72%
Bryk H., Bielenin A., Lewandowska M.
Journal of Fruit and Ornamental Plant Research
|
1996
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tom 04
|
nr 1
11
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Studies on benzimidasole resistance in sheep, cattle, horses and pigs in North-West part Poland

72%
Ramisz A., Balicka-Ramisz A.
Wiadomości Parazytologiczne
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1998
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tom 44
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nr 3
12

Postep w ochronie zboz a fungicydy starej i nowej generacji

71%
Janczak C., Filoda G., Pawlak A.
Progress in Plant Protection
|
2004
|
tom 44
|
nr 2
745-749
13
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Lekooporność nicieni żołądkowo‑jelitowych kóz. Część II. Metody zwalczania i zapobiegania inwazji

58%
Mickiewicz M., Czopowicz M., Moroz A., Szlus-Jordanow O., Nalbert T., Markowska-Daniel I., Kaba J.
Życie Weterynaryjne
|
2022
|
tom 97
|
nr 02
14

Chwościk buraka - niekończąca się opowieść

58%
Piszczek J.
Poradnik Plantatora Buraka Cukrowego
|
2018
|
nr 2
15

Zwalczyć rozpoznanego sprawcę

58%
Korbas M., Jajor E.
Top Agrar Polska
|
2012
|
nr 05
16

Epidemiology of Cercospora leaf spot of sugar beet in central Poland

58%
Piszczek J.
Phytopathologia
|
2011
|
tom 62
17

Wieczny klopot

58%
Bielenin A.
Hasło Ogrodnicze
|
2003
|
nr 08
2-4
18

1H-benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors

58%
Alpan A. S., Gunes H. S., Topcu Z.
Acta Biochimica Polonica
|
2007
|
tom 54
|
nr 3
Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Several benzimidazole derivatives are also active as inhibitors of type I DNA topoisomerases. In this study, three 1H-benzimidazole derivatives with different electronic characteristics at position 5-, namely 5-chloro-4-(1H-benzimidazole-2-yl)phenol (Cpd I), 5-methyl-4-(1H-benzimidazole-2-yl)phenol (Cpd II) and 4-(1H-benzimidazole-2-yl)phenol (Cpd III), were synthesized and evaluated for their effects on mammalian type I DNA topoisomerase activity using quantitative in vitro plasmid supercoil relaxation assays. For the structure elucidation of the compounds, melting points, UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses were interpreted. Among the compounds, 5-methyl-4-(1H-benzimidazole-2-yl)phenol (Cpd II) manifested relatively potent topoisomerase I inhibition.
19

Benzimidazol resistance in nematode parasites in domesticated animals in North-West part Poland

58%
Balicka-Ramisz A. K., Ramisz A. Z.
Electronic Journal of Polish Agricultural Universities. Series Animal Husbandry
|
1999
|
tom 02
|
nr 2
The anthelmintics resistance of nematodes in sheep, cattle, horses and sows was investigated on 4 farms in North-West part Poland. The farms were visited thrice before and twice 7 and 14 days after treatment. During the first visit, groups of 10 animals were formed. All animals were weighted before treatment and from each animal faecal samples were individually taken. One group in each farm remained untreated as a control.
20
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Temporary elevation of pancreatic lysosomal enzymes, as a result of the omeprazole-induced peripancreatic inflammation in male Wistar rats

58%
Burdan F., Siezieniewska Z., Maciejewski R., Burski K., Wojtowicz Z.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 3
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