Wyniki wyszukiwania

1

Comparison between the toxicity of plant origin and synthetic pesticide against fresh water fish Cirrhinus mrigala

100%

Pratap B., Singh A.

Journal of Biology and Earth Sciences

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2015

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tom 05

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nr 1

2

Apigenin inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma [MAT-LyLu] cell populations

100%

Czernik M., Sroka J., Madeja Z., Czyz J.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 3

327-338

Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid abundant in the common fruits, herbs and vegetables constituting the bulk of the human diet. This study was aimed at quantifying the effects of apigenin on the basic cellular traits determining cancer development, i.e. cell proliferation, gap junctional coupling, and motility, using the Dunning rat prostate MAT-LyLu cell model. We demonstrated that apigenin considerably inhibits MAT-LyLu cell proliferation and significantly enhances the intensity of connexin43-mediated gap junctional coupling. This effect correlates with an increased abundance of C×43-positive plaques at the cell-to-cell borders seen in apigenin-treated variants. Moreover, we observed an inhibitory effect of apigenin on the motility of MAT-LyLu cells. The basic parameters characterising MAT-LyLu cell motility, especially the rate of cell displacement, considerably decreased upon apigenin administration. This in vitro data indicates that apigenin may affect cancer development in general, and prostate carcinogenesis in particular, via its influence on cellular activities decisive for both cancer promotion and progression, including cell proliferation, gap junctional coupling and cell motility and invasiveness.

3

Toxicological and biochemical alterations of apigenin extracted from seed of Thevetia peruviana, a medicinal plant

100%

Singh S. K., Singh S. K., Singh A.

Journal of Biology and Earth Sciences

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2013

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tom 03

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nr 1

4

Effects of apigenin on membrane potential in the liverwort Conocephalum conicum

100%

Pawlikowska-Pawlega B., Krol E., Trebacz K., Gawron A.

Biological Letters

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2005

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tom 42

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nr 2 Spec.Vol.

5

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In vitro and in vivo activities of flavonoids - apigenin, baicalin, chrysin, scutellarin - in regulation of hypertension - a review for their possible effects in pregnancy-induced hypertension

80%

Ozarowski M., Kujawski R., Mikolajczak P. L., Wielgus K., Klejewski A., Wolski H., Seremak-Mrozikiewicz A.

Herba Polonica

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2019

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tom 65

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nr 1

Flavonoids and their conjugates are the most important group of natural chemical compounds in drug discovery and development. The search for pharmacological activity and new mechanisms of activity of these chemical compounds, which may inhibit mediators of inflammation and influence the structure and function of endothelial cells, can be an interesting pharmacological strategy for the prevention and adjunctive treatments of hypertension, especially induced by pregnancy. Because cardiovascular diseases have multifactorial pathogenesis these natural chemical compounds with wide spectrum of biological activities are the most interesting source of new drugs. Extracts from one of the most popular plant used in Traditional Chinese Medicine, Scutellaria baicalensis Georgi could be a very interesting source of flavonoids because of its exact content in quercetin, apigenin, chrysin and scutellarin as well as in baicalin. These flavonoids exert vasoprotective properties and many activities such as: anti-oxidative via several pathways, anti-inflammatory, anti-ischaemic, cardioprotective and anti-hypertensive. However, there is lack of summaries of results of studies in context of potential and future application of flavonoids with determined composition and activity. Our review aims to provide a literature survey of in vitro, in vivo and ex vivo pharmacological studies of selected flavonoids (apigenin, chrysin and scutellarin, baicalin) in various models of hypertension carried out in 2008–2018.

6

Polyphenolic composition of Spanish cultivars of globe artichoke (Cynara cardunculus L. var. scolymus (L.) Fiori)

80%

Perez-Esteve E., Salata A., Barat J. M., Stepniowska A., Lopez-Galarza S., Nurzynska-Wierdak R.

Acta Scientiarum Polonorum. Hortorum Cultus

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2018

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tom 17

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nr 2

Globe artichoke (Cynara cardunculus L. var. scolymus (L.) Fiori) is an edible herbaceous perennial plant that plays an important economic role in Mediterranean agriculture. In recent years, extensive research, which aimed to characterize the phenolic profile of the most important globe artichoke cultivars in Italy, has been conducted. However, very little information is available on the phenolic composition of cultivars traditionally grown in Spain. In this work, six cultivars (‘Opal’, ‘Symphony’, ‘Concerto’, ‘Madrigal’, ‘Blanca de Tudela’ and ‘A-106’) cultured in Spain were characterized according to their phenolic content. The phenolic profile differed between cultivars, and also between flower parts. The major phenolic compound in all the different cultivars was chlorogenic acid. Of the six studied cultivars, ‘Madrigal’ had the highest phenolic content.

7

Flavonoids in white and yellow perianths and yellow anthers of tulips [Tulipa gesneriana L.]

80%

Horbowicz M., Saniewski M.

Acta Agrobotanica

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2001

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tom 54

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nr 2

The content of flavonoids in white and yellow perianths and yellow anthers of a few tulip cultivars were determined at the stage of full flowering. To analyses of flavonols a HPLC method was used. In anthers (yellow) of all analyzed cultivars (Oscar, Pax, Profesor Wóycicki, Biała Dama, White Virgin, Calypso, Diana) high content of quercetin (2.35 - 6.01 mg . g-l EW), kaempferol (1.09 - 9.47 mg . g.1 EW) and apigenin (1.34 - 8.24 mg• g-l EW.) was found. In analyzed white perianth of cvs. Oscar and White Virgin also high content of quercetin (1.3 - 1.80 mg . g-l EW) and kaempferol (1.90 mg . g-l EW.) was documented and only traces of apigenin was found. In the yellow perianth of cv. Profesor Wóycicki the level of quercetin and kaempferol was much lower than in perianth of cvs. Oscar and White Virgin, and apigenin was absent.Thus, yellow anthers and white and yellow perianth of tulip cultivars are a rich source of flavonols.

Ograniczanie wyników

Comparison between the toxicity of plant origin and synthetic pesticide against fresh water fish Cirrhinus mrigala

Apigenin inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma [MAT-LyLu] cell populations

Toxicological and biochemical alterations of apigenin extracted from seed of Thevetia peruviana, a medicinal plant

Effects of apigenin on membrane potential in the liverwort Conocephalum conicum

In vitro and in vivo activities of flavonoids - apigenin, baicalin, chrysin, scutellarin - in regulation of hypertension - a review for their possible effects in pregnancy-induced hypertension

Polyphenolic composition of Spanish cultivars of globe artichoke (Cynara cardunculus L. var. scolymus (L.) Fiori)

Flavonoids in white and yellow perianths and yellow anthers of tulips [Tulipa gesneriana L.]