Wyniki wyszukiwania

1

Effects of post-weaning social isolation and environmental enrichment on exploratory behavior and anxiety in Wistar rats

100%

Tanas L., Ostaszewski P., Iwan A.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 1

Adverse early experience is generally regarded as a risk factor for both externalizing and internalizing behavioral disorders in humans. It can be modeled in rats by a post-weaning social isolation procedure. Effects of social isolation might possibly be ameliorated by environmental enrichment. In the current study, 24 male Wistar rats were divided post-weaning into four rearing conditions: control, environmental enrichment (EE), social isolation (SI) and a combination of the two experimental conditions; (EE+SI). Two observations of the effects of rearing conditions on the rate of social and object interactions were conducted during the juvenile and post-pubertal stages of development. The SI condition led to a marked increase of social interactions during the juvenile phase, but did not affect object interactions. The EE condition increased the level of social interactions during both the juvenile and post-pubertal measurements. The effects of early rearing conditions on adult exploratory behavior were less clear, with a significant difference between the groups obtained in one of three behavioral tests. Results suggest a general robustness in the development of adult exploratory behavior and anxiety when rats were exposed to early social isolation and provided brief opportunities for social play during the juvenile period. Further studies, aimed at distinguishing play-related protective factors serving against long-term adverse effects of juvenile social isolation, are suggested.

2

Does the non-genomic effect of testosterone on social anxiety require the presence of a classical steroid receptor?

100%

Filova B., Domonkos E., Borbelyova V., Babickova J., Tothova L., Ostatnikova D., Celec P., Hodosy J.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 4

Steroid hormones may act through a rapid mechanism that does not require an intracellular steroid receptor and its effects on gene expression. In this study we have analysed this so-called non-genomic effect of testosterone on social anxiety in rats of both sexes using androgen and oestrogen receptor blockers. Male rats were divided into four groups: SHAM-CTRL (a sham operated group treated with oil as vehicle, n=10), SHAM-TST (a sham operated group treated with testosterone at a dose of 1 mg/kg, n=10), GDX-CTRL (a castrated group treated with oil, n=10) and GDX-TST (a castrated group treated with testosterone at a dose of 1 mg/kg, n=10). Female rats were divided into two groups: OVX-CTRL (an ovariectomized group treated with oil, n=10) and OVX-TST (an ovariectomized group treated with testosterone, n=10). The intracellular androgen receptor was blocked with flutamide and both intracellular oestrogen receptors were blocked with tamoxifen (a selective oestrogen receptor modulator). Rats were tested one hour after oil or testosterone administration in the social interaction test. Although the concentration of testosterone was higher in testosterone groups, no significant difference in social interaction was observed between the groups. In summary, in this first study focusing on the non-genomic effects of testosterone on social interaction no rapid effects of testosterone in adult rats were found. Further studies should analyse potential nongenomic effects of testosterone on other forms of social behaviour.

3

The role of selected intrapsychic factors in Alpine skiing instruction

100%

Makowski K., Aschenbrenner P., Krawczynski B.

Baltic Journal of Health and Physical Activity. The Journal of Gdansk University of Physical Education and Sport

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2014

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tom 06

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nr 2

Background: This research was aimed at describing the influence of selected intrapsychic factors related to “low” and “high” mountain conditions upon the efficiency of alpine skiing instruction. Material/Methods: Research participants were 48 people without skiing skills. Altitudes from 770 to 1,741 metres above sea level were chosen for “high” groups. A STAI questionnaire was chosen in order to carry out the research. The skiing level achieved by the end of the instruction was assessed expertly with the three essential evolutions, i.e. ploughing curves, slanting slide, and half-ploughing turn, taken into consideration. Results: The anxiety level after the instruction of the “high” group exceeded that in the “low” group (p<0.0895). Significant negative correlations were observed between the mean score for technical evolutions and the accompanying anxiety in the “high” group of subjects. Conclusions: The lower the characteristic anxiety, the better the technical test results. Whenever skiing evolutions are taught, it is necessary to take into consideration both the students’ anxiety levels and their physical effectiveness levels. Contributions to the awareness of skiing instruction participants can increase their mental resistance and result in a better final effect of such an instruction.

4

Relationship between mental skills and anxiety interpretation in female volleyball players

100%

Varzaneh A. G., Saemi E., Shafinia P., Zarghami M., Ghamari A.

Studies in Physical Culture and Tourism

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2011

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tom 18

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nr 1

5

Obstetrical consequences and experienced anxiety in women with symptoms of imminent abortion

100%

Kraczkowski J., Smolen A., Szymona K., Krzyzanowski A., Semczuk-Sikora A.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

Psychological factors, such as anxiety, fatigue or stress, may influence the course of pregnancy and lead to spontaneous abortions. Psychological comfort is advised to increase symptoms regression and successful termination of pregnancy. The study aimed to evaluate the intensification and characteristics of anxiety in women with symptoms of imminent abortion and to analyze the relationship between anxiety and obstetrical complications. 30 pregnant women hospitalized with the diagnosis of imminent abortion symptoms were enrolled in the study as the group. Another 30 women with normal pregnancy were the control. Authors made use of the Cattell Personality Factor Test by K. Hirszl and The Self-Reported Anxiety Scale by C.D. Spielberg, R.L. Gorsucha and R.E. Lushene. High level of anxiety that accompanies symptoms of imminent abortion is believed to be a secondary risk factor for preterm pregnancy termination.

6

Effects of angiotensin II and its receptor antagonists on motor activity and anxiety in rats

100%

Braszko J. J., Kulakowska A., Winnicka M. M.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 2

The neuropeptide angiotensin II (Ang II) has been recently found to be involved in cognitive processes. Both AT1 and AT2 angiotensin receptors seem to mediate this action. However, unspecific behavioural effects of the peptide, particularly motor and emotional, appear to influence the interpretation of cognition-oriented tests and contribute to considerable differences in opinions of various authors on the subject. In this study, aimed specifically at the assessment of these effects, we found small and insignificant changes in motor performance measured in open field after intracebroventricular injections of Ang II and its receptor subtype-specific antagonists; losartan (AT1) and PD 123319 (AT2). However, Ang II was found to increase substantially anxiety measured in elevated 'plus' maze and impair motor coordination measured in 'chimney test'. Interestingly, both antagonists abolished Ang II generated anxiety and only losartan counteracted impaired motor coordination caused by the peptide. The AT2 receptor antagonist PD 123319 impairing motor coordination on its own, nonetheless partly diminished that caused by Ang II. Therefore it appears safe to conclude that mood but not motor effects of AT1 and AT2 receptor affecting drugs may significantly bias interpretation of the cognition - oriented tests on these drugs.

7

Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice

100%

Volke V., Wegener G., Vasar E.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

Several studies have reported the anxiolytic-like effects of various nitric oxide synthase inhibitors in distinct animal models. However, in the context of anxiety, the possible involvement of cyclic GMP, believed to be one of the main targets of NO, remains obscure. Cyclic GMP is degraded by the specific phosphodiesterases in the brain. Therefore, we studied the effect of the selective phosphodiesterase type 5 inhibitor sildenafil in the mouse elevated plus-maze test of anxiety and in the open field test of locomotion. We found that sildenafil (0.05-10 mg/kg i.p.) alone did not affect the behavior of animals in the plus-maze or open field tests, but the anxiogenic beta-carboline DMCM given in a subconvulsive dose (2 mg/kg i.p.) decreased the time spent on open arms in the elevated plus-maze. Treatment with the NO precursor L-arginine (200 mg/kg i.p.) did not modify the behavior of animals in the plus-maze, however, when sildenafil (1 mg/kg i.p.) was administered in combination with L-arginine (200 mg/kg i.p.), both the time spent on the open arms and the percentage of open arm visits were significantly decreased. We conclude that augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice.

8

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders

100%

Rymaszewska J., Ramsey D., Chladzinska-Kiejna S.

Archivum Immunologiae et Therapiae Experimentalis

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2008

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tom 56

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nr 1

9

Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women

84%

Chojnacki C., Walecka-Kapica E., Klupinska G., Pawlowicz M., Blonska A., Chojnacki J.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 5

10

The influence of acute progressive hypoxia on bioelectrical activity of the brain

84%

Jernajczyk W., Sobanska A., Marczak M., Maciejewski A., Latka M., West B., Pokorski M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

165-174

Hypoxia, a noxious and hyperventilatory stimulus and a modifier of neuronal metabolism, could influence cortical function. In this study we attempted to assess any such influence, its determinants, and particularly the role in it of the accompanying hypoxic emotional distress. We addressed the issue by examining the associations among EEG, ventilation, and anxiety during progressive poikilocapnic hypoxia (end-point SaO2 75%) in 12 awake healthy volunteers (mean age 27.5 ±0.7 yr). All subjects hyperventilated in response to hypoxia and 3 of them had a high level of anticipatory anxiety that forced one person to discontinue the test. We failed to show any major effect of hypoxia on the EEG pattern analyzed by visual inspection or wavelet power spectra. Therefore, no relationship between the ventilatory and cortical activity responses to hypoxia could be established. Cortical activity changes appeared, however, in the subjects who experienced emotional distress during the test. These changes were apparent on an expanded analysis of the EEG signal by the use of the Lempel-Ziv complexity that takes into account the ordering of variations in the signal, rather than only the relative frequency of events analyzed by the Shannon entropy. The Lempel-Ziv complexity offers promise as a novel method for unraveling fine and otherwise unexpressed alterations in cortical bioelectrical activity.

11

Competence as a factor of reduction of employees’ anxiety

84%

Strykowska M.

Intercathedra

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2011

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tom 27

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nr 4

A significant part amongst various factors causing fear in modern people is related to professional work. First, a person fears that they will not be employed, then that they will not meet the requirements, and eventually that they will be dismissed. In contemporary organizations, often called knowledge organizations, competence plays a special role in alleviation of the sense of fear.

12

The role of interleukin 6 in stress response and anxiety-driven behavior in mice

84%

Aniszewska A., Chlodzinska N., Turlejski K., Djavadian R.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

Interleukin 6 (IL-6) plays an important role in stress response and glucocorticoid action on the brain. It has been also shown that IL-6 plays a significant role in physiological and pathological brain development and is a crucial factor in the effects of prenatal immune challenge on physiological and behavioral abnormalities in adult offspring. We examined involvement of IL-6 in stressinduced changes in behavior and brain mechanisms in the adult mice. The PhenoRack system was used to non-invasively monitor mice home cage activity. Behavior of wild type mice C57BL/6J and IL-6 -/- knockout (IL-6 KO) mice were observed for 3 days using the PhenoRack system, which enables non-invasive monitoring of the mice home-cage activity (distance travelled, speeds and duration of movement, freezing). Mice were also subjected to standard behavioral tests. The open field test was used to establish the balance between exploratory behavior and anxiety evoked by the unknown, potentially dangerous situation. We measured the distance travelled in the open part of the arena, as well as time spent in it. We observed the sex-dependent effect of IL-6 on exploratory behavior. In all tested parameters IL-6 deficient females showed less anxiety than the wild type females. There was no difference in behavior in the open field between wild type and IL-6 deficient males. After finishing behavioral tests, the animals were killed with an overdose of pentobarbital and their brains were perfused transcardially with saline (0.9% NaCl) followed by 4% paraformaldehyde in 0.1 M phosphate buffer. The brains were cut on a cryostat into 40 µm sections and collected into 10 parallel series. Two of these series were stained with antibodies against glucocorticoid (GR) and mineralocorticoid (MR) receptors. One series from each brain was Nissl-stained for delineation of borders of the brain structures and evaluation of the number of cells in some of them. The number of hippocampal neurons and GRimmunopositive neurons in an area was estimated using the StereoInvestigator system (MicroBrightField Inc). Due to the crucial role of IL-6 in development of the hippocampus we evaluated the total number of cells in the CA1 field. We found that IL-6- deficient mice had significantly lower number of cells in the CA1 field and that almost all cells, unlike in wild-type mice, expressed the glucocorticoid receptor. Our preliminary results demonstrated that IL-6 is implicated in stress. Supported by the Polish National Science Center grant No 1577

13

Effects of the cannabinoid receptor ligands on anxiety-related effects of D-amphetamine and nicotine in the mouse elevated plus maze test

84%

Biala G., Kruk M., Budzynska B.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

113-122

The purpose of the experiments was to examine the anxiety-related effects of d-amphetamine and nicotine, and the possible involvement of the endocannabinoid system. D-amphetamine (2 mg/kg, ip) was administered acutely or daily for 8 days. On the 9th day, mice were challenged with d-amphetamine (2 mg/kg, ip) or nicotine (0.1 mg/kg, sc), and were tested in the elevated plus maze. Additionally, a distinct group of mice was pretreated with an acute (0.1 mg/kg, sc) or subchronic nicotine (6 days), and subjected to nicotine (0.1 mg/kg, sc) or d-amphetamine (2 mg/kg, ip) challenge on the 7th day. The cannabinoid receptor ligands, WIN 55,212-2, a non-selective cannabinoid receptor agonist (0.25; 0.5 and 1 mg/kg, ip) and rimonabant, a CB1 cannabinoid receptor antagonist (0.25; 0.5; 1 and 2 mg/kg, ip) were injected prior to each injection of saline or acute and subchronic d-amphetamine or nicotine. We observed that acute anxiogenic and subchronic anxiolytic effects of both psychostimulants as well as the development of full cross-tolerance to their anxiogenic effects were dose-dependently blunted by ineffective doses of WIN 55,212-2 (0.25 and 0.5 mg/kg) and rimonabant (0.5 and 1 mg/kg). These results provide evidence that the endogenous cannabinoid system is involved in the anxiety-related responses to d-amphetamine and/or nicotine.

14

Breast cancer surgery decreases serum brain-derived neurotrophic factor concentrations in middle aged women: relationship to the serum C-reactive protein concentration

84%

Zoladz J. A., Nowak L. R., Majerczak J., Kulpa J., Pilc A., Duda K.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 4

15

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Occurrence of depression and anxiety disorders according to the period of abstinence in patients addicted to gambling and alcohol

84%

Makara-Studzinska M., Pylypczuk A., Urbanska A.

Journal of Pre-Clinical and Clinical Research

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2011

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tom 05

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nr 1

16

Developmental lead exposure impairs anxiolytic-like effect of diazapam and 8-OH-DPAT in male Wistar rats

84%

Nowak P., Kostrzewa R. M., Adamus-Sitkiewicz B., Brus R.

Polish Journal of Environmental Studies

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2008

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tom 17

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nr 5

751-756

The effects of developmental lead (Pb²⁺) exposure on the anxiolytic-like effect of diazepam (5.0 mg/kg IP) and 8-OH-DPAT (0.3 mg/kg IP) were studied. Wistar dams were exposed to 250 ppm lead acetate in drinking water during pregnancy. Control rats were derived from dams that consumed tap water, and had no exposure to Pb²⁺ afterwards. Male offspring were tested at the age of 12 weeks. We studied the anxiolytic-like effect of diazepam and 8-OH-DPAT in an elevated plus maze device and the Vogel conflict test. Diazepam in doses of 5.0 mg/kg IP significantly increased the percentage of time spent on open arms in control rats being without effect in Pb²⁺-exposed animals. 8-OH-DPAT 0.3 mg/kg IP increased the percentage of time spent on open arms in both experimental groups (control and Pb²⁺), but the anxiolytic-like effect was much more pronounced in Pb²⁺-intoxicated animals. The benzodiazepine anxiolytic diazepam produced a significant effect in the Vogel conflict test in control rats. A 5.0 mg/kg dose of those drugs caused a significant increase in the number of electric shocks rats received. In the ontogenetically Pb²⁺-exposed rats diazepam also augmented the number of shocks accepted, but this effect was much less pronounced than in control animals. Conversely, 8-OH-DPAT at doses of 0.3 mg/kg IP was without effect in both tested groups as far as the anticonflict effect is concerned. The results of the present report demonstrated that exposure to Pb²⁺ during pregnancy induced hypersensitivity to 5-HT1A agonist mediated anxiolytic-like effect but attenuated that of benzodiazepine (diazepam).

17

Obstructive sleep apnea and the quality of life

84%

Glebocka A., Kossowska A., Bednarek M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

111-117

Patients suffering from obstructive sleep apnea (OSA) are unaware of clinical symptoms, such as cessation of breathing during sleep, decrease in blood oxygen levels, severe sleep fragmentation, and excessive daytime sleepiness. Equally worrying is a low level of knowledge among physicians, psychiatrists, and psychologists of the intellectual and emotional impact of OSA. The illness may lead to anxiety, depression, psychosis, and other pathological symptoms. The aim of the present study was to evaluate relationships among OSA, quality of life, and psychological performance. STAI, UMACL, the Beck Depression Inventory, the Framingham Type A Scale, the Courtauld Emotional Control Scale (CECS), the Life Orientation Test - Revised (LOT-R), and the Satisfaction With Life Scale (SWLS) were applied. The tests were used to describe the well-being and pathological symptoms, such as depression or anxiety, in a clinical group (newly-diagnosed, untreated OSA patients) in comparison with a control group (healthy volunteers). The results of the tests failed to substantiate the presence of significant differences between the clinical and control groups. We put forward a hypothesis that the rather unexpected lack of psychological differences might stem from a rapid mood improvement in OSA patients on anticipation of being diagnosed and taken care of in the hospital setting. Followed-up studies in the same patients are required to confirm this hypothesis.

18

Experimental modelling of anxiety and depression

84%

Kalueff A. V., Tuohimaa P.

Acta Neurobiologiae Experimentalis

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2004

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tom 64

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nr 4

19

Expression of c-Fos in response to stressogenic stimuli in the amygdala of old vs. young rats - a preliminary study

84%

Boguszewski P., Zagrodzka J.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 2

20

Spontaneous behavior of the gray short-tailed opossum [Monodelphis domestica] in the elevated plus-maze: comparison with Long-Evans rats

84%

Wesierska M., Turlejski K.

Acta Neurobiologiae Experimentalis

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2000

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tom 60

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nr 4

We observed the spontaneous behavior of a laboratory marsupial - the gray short-tailed opossum (Monodelphis domestica) - in the elevated plus-maze (EPM) during six consecutive sessions and compared it with the behavior of Long-Evans rats. During the first exposure to the maze both species spent most of the time in the enclosed arms but opossums showed much higher frequency of entries into the open arms and stayed there longer. On the third and subsequent days opossums reduced their entries into the open arms and spent more time on the central square, where unlike rats they frequently groomed their lower belly and hind legs. During the last sessions they started spending more time in the enclosed arms. It is concluded that probably opossums, like rats show a stable anxiety evoked by open space. However, in the rat anxiety prevails over motivation to explore a new environment, while in the opossum it is initially at equilibrium with curiosity which habituates slower than in the rat. Results are discussed in the context of different ecology of the gray opossum that actively searches and hunts quickly moving insects. Thigmotaxic behavior, while strong in both species, dominates spontaneous behavior of the rat, but not opossum.

Ograniczanie wyników

Effects of post-weaning social isolation and environmental enrichment on exploratory behavior and anxiety in Wistar rats

Does the non-genomic effect of testosterone on social anxiety require the presence of a classical steroid receptor?

The role of selected intrapsychic factors in Alpine skiing instruction

Relationship between mental skills and anxiety interpretation in female volleyball players

Obstetrical consequences and experienced anxiety in women with symptoms of imminent abortion

Effects of angiotensin II and its receptor antagonists on motor activity and anxiety in rats

Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders

Effects of fluoxetine and melatonin on mood, sleep quality and body mass index in postmenopausal women

The influence of acute progressive hypoxia on bioelectrical activity of the brain

Competence as a factor of reduction of employees’ anxiety

The role of interleukin 6 in stress response and anxiety-driven behavior in mice

Effects of the cannabinoid receptor ligands on anxiety-related effects of D-amphetamine and nicotine in the mouse elevated plus maze test

Breast cancer surgery decreases serum brain-derived neurotrophic factor concentrations in middle aged women: relationship to the serum C-reactive protein concentration

Occurrence of depression and anxiety disorders according to the period of abstinence in patients addicted to gambling and alcohol

Developmental lead exposure impairs anxiolytic-like effect of diazapam and 8-OH-DPAT in male Wistar rats

Obstructive sleep apnea and the quality of life

Experimental modelling of anxiety and depression

Expression of c-Fos in response to stressogenic stimuli in the amygdala of old vs. young rats - a preliminary study

Spontaneous behavior of the gray short-tailed opossum [Monodelphis domestica] in the elevated plus-maze: comparison with Long-Evans rats